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Map2 Gene Detail
Summary
  • Symbol
    Map2
  • Name
    microtubule-associated protein 2
  • Synonyms
    G1-397-34, MAP-2, Mtap2, repro4
  • Feature Type
    protein coding gene
  • IDs
    MGI:97175
    NCBI Gene: 17756
  • Gene Overview
    MyGene.info: MAP2
Location & Maps
more
  • Sequence Map
    Chr1:66175273-66442583 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      267311 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 33.49 cM
  • Mapping Data
    15 experiments
Homology
more
  • Human Ortholog
    MAP2, microtubule associated protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MAP2, microtubule associated protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MAP2A, MAP2B, MAP2C
  • Links
    NCBI Gene ID: 4133
    neXtProt AC: NX_P11137

  • Chr Location
    2q34-q35; chr2:209424047-209734118 (+)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 1779
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 frog, western clawed
  • HCOP
    human homology predictions: MAP2
  • Gene Tree
    Map2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 3 alleles in 4 genetic backgrounds
    10 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Map2
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit altered contextual memory. Mice homozygous for another knock-out allele display decreased body weight, altered microtubule density and organization in Purkinje cell dendrites, and reduced dendritic length inhippocampal neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    38
  • GO References
    33
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    343
  • Tissues
    137
  • cDNA Data
    286
  • Literature Summary
    294
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016448 VEGA Gene Model | MGI Sequence Detail 267311 C57BL/6J ±  kb
transcript OTTMUST00000039627 VEGA | MGI Sequence Detail 6258 Not Applicable  
polypeptide OTTMUSP00000017690 VEGA | MGI Sequence Detail 1828 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    3229 from dbSNP Build 142
  • RFLP
    3
Protein
Information
less
  • UniProt
    16 Sequences
  • Protein Ontology
    PR:000010124 microtubule-associated protein 2
  • InterPro Domains
    IPR013588 MAP2/Tau projection
    IPR030797 Microtubule-associated protein 2
    IPR027324 Microtubule associated protein MAP2/MAP4/Tau
    IPR001084 Microtubule associated protein, tubulin-binding repeat
    IPR018459 RII binding domain
Molecular
Reagents
less
  • All nucleic 299
    cDNA 293
    Primer pair 5
    Other 1

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-12580, MGD-MRK-12585, MGI:3512774
References
more
  • Summaries
    All 375
    Developmental Gene Expression 294
    Gene Ontology 33
    Phenotypes 15
  • Earliest
    J:201 Strong LC, et al., bw allele at mi. Mouse News Lett. 1961;25:9
  • Latest
    J:231963 Matsumoto S, et al., Brg1 directly regulates Olig2 transcription and is required for oligodendrocyte progenitor cell specification. Dev Biol. 2016 May 15;413(2):173-87
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory