Map2
Gene Detail

Symbol Name ID

Map2 microtubule-associated protein 2 MGI:97175

Synonyms

G1-397-34, MAP-2, Mtap2, repro4

Feature Type

protein coding gene

Genetic Map

Chromosome 1

33.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr1:66175273-66442583 bp, + strand From VEGA annotation of GRCm38   267311 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1779  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Map2

Human homologs

Human Homolog		MAP2, microtubule-associated protein 2
NCBI Gene ID		4133
neXtProt AC		NX_P11137
Human Synonyms		MAP2A, MAP2B, MAP2C
Human Chr (Location)		2q34-q35; chr2:209424009-209734118 (+)  GRCh38

Alleles and phenotypes

All alleles(5) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(3)
Incidental mutations (data from APF )
 

Mice homozygous for a knock-out allele exhibit altered contextual memory. Mice homozygous for another knock-out allele display decreased body weight, altered microtubule density and organization in Purkinje cell dendrites, and reduced dendritic length in hippocampal neurons.

 

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	axonogenesis, cellular response to organic substance, ...
Component	cell body, cytoplasm, ...
Function	calmodulin binding, cytoskeletal regulatory protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (261 records)

Data Summary: Results (288)    Tissues (110)    Images (134)
Theiler Stages: 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	93
RNA in situ	130
Western blot	26
RT-PCR	39

cDNA source data(285)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(298) cDNA(292) Primer pair(5) Other(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000016448 (Evidence)
Ensembl Gene Model	ENSMUSG00000015222 (Evidence)
Entrez Gene	17756 (Evidence)
UniGene	256966
DFCI	TC1579134, TC1598809, TC1605207, TC1614449, TC1631091, TC1633665
DoTS	DT.101388703, DT.101718391, DT.103588928, DT.110926208, DT.528913, DT.91552187, DT.99849433
NIA Mouse Gene Index	U042170
Consensus CDS Project	CCDS15020.1, CCDS35602.1
International Mouse Knockout Project Status	Map2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016448	VEGA Gene Model | MGI Sequence Detail	267311	C57BL/6J
transcript	OTTMUST00000039627	VEGA | MGI Sequence Detail	6258	Not Applicable
polypeptide	OTTMUSP00000017690	VEGA | MGI Sequence Detail	1828	Not Applicable

All sequences(174) RefSeq(46) UniProt(16)

Polymorphisms

RFLP(3) : SNPs within 2kb(3280 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR013588	MAP2/Tau projection
InterPro	IPR027324	Microtubule associated protein MAP2/MAP4/Tau
InterPro	IPR018459	RII binding domain
InterPro	IPR001084	Tau and MAP proteins tubulin-binding repeat
Protein Ontology	PR:000010124	microtubule-associated protein 2

References

(Earliest) J:28223 Lewis SA, et al., Brain-specific expression of MAP2 detected using a cloned cDNA probe. J Cell Biol. 1986 Jun;102(6):2098-105
(Latest) J:205042 Osorio C, et al., Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development. Development. 2013 Dec;140(23):4751-62
All references(340)

Other accession IDs

MGD-MRK-12580, MGD-MRK-12585, MGI:3512774