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Map2
Gene Detail
 Symbol
Name
ID
Map2
microtubule-associated protein 2
MGI:97175
Synonyms G1-397-34, MAP-2, Mtap2, repro4
Feature Type protein coding gene
Genetic Map
Chromosome 1
33.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr1:66175273-66442583 bp, + strand
From VEGA annotation of GRCm38

  267311 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1779  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Map2

Human
homologs
Human Homolog MAP2, microtubule-associated protein 2
NCBI Gene ID 4133
neXtProt AC  NX_P11137
Human Synonyms  MAP2A, MAP2B, MAP2C
Human Chr (Location)  2q34-q35; chr2:209424009-209734118 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit altered contextual memory. Mice homozygous for another knock-out allele display decreased body weight, altered microtubule density and organization in Purkinje cell dendrites, and reduced dendritic length in hippocampal neurons.
 
Interactions
Map2 interacts with 435 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process axonogenesis, cellular response to organic substance, ...
Component cell body, cytoplasm, ...
Function calmodulin binding, cytoskeletal regulatory protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (262 records)
Data Summary: Results (288)    Tissues (115)    Images (134)
Theiler Stages: 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 93
RNA in situ 130
Western blot 26
RT-PCR 39
cDNA source data(285)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(298) cDNA(292) Primer pair(5) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000016448 (Evidence)
Ensembl Gene ModelENSMUSG00000015222 (Evidence)
Entrez Gene17756 (Evidence)
UniGene256966
DFCITC1579134, TC1598809, TC1605207, TC1614449, TC1631091, TC1633665
DoTSDT.101388703, DT.101718391, DT.103588928, DT.110926208, DT.528913, DT.91552187, DT.99849433
NIA Mouse Gene IndexU042170
Consensus CDS ProjectCCDS15020.1, CCDS35602.1
International Mouse Knockout Project StatusMap2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016448 VEGA Gene Model | MGI Sequence Detail 267311 C57BL/6J ±  kb
transcript OTTMUST00000039627 VEGA | MGI Sequence Detail 6258 Not Applicable 
polypeptide OTTMUSP00000017690 VEGA | MGI Sequence Detail 1828 Not Applicable 

For the selected sequences
All sequences(175) RefSeq(46) UniProt(16)
Polymorphisms RFLP(3) : SNPs within 2kb(3280 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013588 MAP2/Tau projection
InterPro IPR027324 Microtubule associated protein MAP2/MAP4/Tau
InterPro IPR018459 RII binding domain
InterPro IPR001084 Tau and MAP proteins tubulin-binding repeat
Protein Ontology PR:000010124 microtubule-associated protein 2
References (Earliest) J:28223 Lewis SA, et al., Brain-specific expression of MAP2 detected using a cloned cDNA probe. J Cell Biol. 1986 Jun;102(6):2098-105
(Latest) J:208651 Louvi A, et al., Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration. Development. 2014 Mar;141(6):1404-15
All references(341)
Other
accession IDs
MGD-MRK-12580, MGD-MRK-12585, MGI:3512774

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory