Map2 MGI Mouse Gene Detail - MGI:97175 - microtubule-associated protein 2

Symbol

Map2
Name

microtubule-associated protein 2
Synonyms

G1-397-34, MAP-2, Mtap2, repro4

Feature Type

protein coding gene
IDs

MGI:97175
NCBI Gene: 17756
Gene Overview

MyGene.info: MAP2
Alliance

gene page
Transcription Start Sites

23 TSS

Sequence Map

Chr1:66175273-66442583 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 33.49 cM
Mapping Data

15 experiments

SNPs within 2kb

3229 from dbSNP Build 142
Strain Annotations

18
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97175	protein coding gene	Chr1:66175246-66442583 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016112	protein coding gene	Chr1:66425946-66705450 (+)
A/J	MGP_AJ_G0016095	protein coding gene	Chr1:64086030-64350654 (+)
AKR/J	MGP_AKRJ_G0016052	protein coding gene	Chr1:65897571-66172682 (+)
BALB/cJ	MGP_BALBcJ_G0016050	protein coding gene	Chr1:64144367-64411595 (+)
C3H/HeJ	MGP_C3HHeJ_G0015881	protein coding gene	Chr1:66150240-66422853 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016503	protein coding gene	Chr1:68984271-69265793 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014224	protein coding gene	Chr1:60042548-60301352 (+)
CAST/EiJ	MGP_CASTEiJ_G0015465	protein coding gene	Chr1:65395417-65668484 (+)
CBA/J	MGP_CBAJ_G0015854	protein coding gene	Chr1:71198334-71506430 (+)
DBA/2J	MGP_DBA2J_G0015955	protein coding gene	Chr1:63468303-63735085 (+)
FVB/NJ	MGP_FVBNJ_G0015958	protein coding gene	Chr1:62724873-62990569 (+)
LP/J	MGP_LPJ_G0016027	protein coding gene	Chr1:67351886-67644171 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015978	protein coding gene	Chr1:74176805-74481148 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016550	protein coding gene	Chr1:65845321-66123294 (+)
PWK/PhJ	MGP_PWKPhJ_G0015252	protein coding gene	Chr1:62858015-63124683 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015031	protein coding gene	Chr1:65316655-65595046 (+)
WSB/EiJ	MGP_WSBEiJ_G0015527	protein coding gene	Chr1:65590442-65861339 (+)

Human Ortholog

MAP2, microtubule associated protein 2

Vertebrate Orthologs

9

Human Ortholog

MAP2, microtubule associated protein 2
Orthology source: HomoloGene, HGNC
Synonyms

MAP-2, MAP2A, MAP2B, MAP2C
Links

HGNC:6839

NCBI Gene ID: 4133

neXtProt AC: NX_P11137

UniProt: P11137
Chr Location

2q34; chr2:209424047-209734118 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 1779
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: MAP2
Gene Tree

Map2

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Phenotype Summary

15 phenotypes from 3 alleles in 4 genetic backgrounds
10 phenotypes from multigenic genotypes
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Map2
Incidental Mutations

APF
Find Mice (IMSR)

2 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit altered contextual memory. Mice homozygous for another knock-out allele display decreased body weight, altered microtubule density and organization in Purkinje cell dendrites, and reduced dendritic length inhippocampal neurons.

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All GO Annotations

75
GO References

39

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

403
Tissues

158
cDNA Data

287
Literature Summary

350

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase map2

ZFIN map2

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Map2 interacts with 434 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

165
RefSeq

68
UniProt

16
CCDS

CCDS15020.1, CCDS35602.1, CCDS83550.1
UniGene

256966

Ensembl

ENSMUSG00000015222 (Evidence)
NCBI Gene

17756 (Evidence)

			Length	Strain/Species	Flank
genomic	ENSMUSG00000015222	Ensembl Gene Model \| MGI Sequence Detail	267311	C57BL/6J	± kb
transcript	ENSMUST00000114013	Ensembl \| MGI Sequence Detail	6258	Not Applicable
polypeptide	ENSMUSP00000109646	Ensembl \| MGI Sequence Detail	1828	Not Applicable

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UniProt

16 Sequences
Protein Ontology

PR:000010124 microtubule-associated protein 2

(term hierarchy)
InterPro Domains

IPR013588 MAP2/Tau projection

IPR030797 Microtubule-associated protein 2

IPR027324 Microtubule associated protein MAP2/MAP4/Tau

IPR001084 Microtubule associated protein, tubulin-binding repeat

IPR018459 RII binding domain

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All nucleic 300

cDNA 294

Primer pair 5

Other 1

Microarray probesets 8

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MGD-MRK-12580, MGD-MRK-12585, MGI:3512774

Summaries

All 449

Developmental Gene Expression 350

Gene Ontology 39

Phenotypes 17
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:276703 Shi J, et al., Dennd1a, a susceptibility gene for polycystic ovary syndrome, is essential for mouse embryogenesis. Dev Dyn. 2019 May;248(5):351-362

TSS for Map2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7132	Chr1:66175167-66175180 (+)	-99 bp
Tssr7133	Chr1:66175188-66175199 (+)	-79 bp
Tssr7134	Chr1:66175209-66175220 (+)	-58 bp
Tssr7135	Chr1:66175236-66175247 (+)	-31 bp
Tssr7136	Chr1:66175248-66175269 (+)	-14 bp
Tssr7137	Chr1:66175272-66175283 (+)	5 bp
Tssr7138	Chr1:66175286-66175348 (+)	44 bp
Tssr7142	Chr1:66321708-66321715 (+)	146,439 bp
Tssr7143	Chr1:66321732-66321739 (+)	146,463 bp
Tssr7144	Chr1:66321753-66321756 (+)	146,482 bp
Tssr7145	Chr1:66321795-66321806 (+)	146,528 bp
Tssr7146	Chr1:66321809-66321820 (+)	146,542 bp
Tssr7147	Chr1:66321825-66321861 (+)	146,570 bp
Tssr7148	Chr1:66321971-66321980 (+)	146,703 bp
Tssr7149	Chr1:66321991-66322012 (+)	146,729 bp
Tssr7150	Chr1:66322021-66322044 (+)	146,760 bp
Tssr7151	Chr1:66322046-66322073 (+)	146,787 bp
Tssr7152	Chr1:66322079-66322090 (+)	146,812 bp
Tssr7153	Chr1:66322108-66322119 (+)	146,841 bp
Tssr7155	Chr1:66364623-66364663 (+)	189,370 bp
Tssr7156	Chr1:66364665-66364680 (+)	189,400 bp
Tssr7157	Chr1:66386917-66386967 (+)	211,669 bp
Tssr7158	Chr1:66386968-66386999 (+)	211,711 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/15/2019 MGI 6.14