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Mt3
Gene Detail
Symbol

Name
ID
Mt3
metallothionein 3
MGI:97173
Synonyms
MT-3
Feature Type
protein coding gene
Genetic Map
Chromosome 8
46.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:94152607-94154148 bp, + strand
From NCBI annotation of GRCm38

  1542 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Gene Tree: Mt3
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Mice homozygous for a knock-out allele exhibit a zinc deficiency in several brain regions, abnormal astrocyte morphology, increased susceptibility to kainic acid induced seizures, and altered zinc accumulation and neuronal death in certain brain areas following seizure-induced or acute brain injury.
 
Interactions
Mt3 interacts with 21 markers (Mir325, Mir328, Mir669a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process astrocyte development, cadmium ion homeostasis, ...
Component cell, synaptic vesicle
Function metal ion binding, zinc ion binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (132)    Tissues (32)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 83
Northern blot 49
cDNA source data(36)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) Genomic(2) cDNA(36) Primer pair(2) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000031760 (Evidence)
Entrez Gene17751 (Evidence)
UniGene2064
DFCITC1582090
DoTSDT.99849866
NIA Mouse Gene IndexU009655
PDB1JI9
Consensus CDS ProjectCCDS40436.1
International Mouse Knockout Project StatusMt3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17751 NCBI Gene Model | MGI Sequence Detail 1542 C57BL/6J ±  kb
transcript NM_013603 RefSeq | MGI Sequence Detail 538 C57BL/6 
polypeptide P28184 UniProt | EBI | MGI Sequence Detail 68 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(1 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017854 Metallothionein domain
InterPro IPR023587 Metallothionein domain, vertebrate
InterPro IPR003019 Metallothionein superfamily, eukaryotic
InterPro IPR000006 Metallothionein, vertebrate
InterPro IPR018064 Metallothionein, vertebrate, metal binding site
Protein Ontology PR:000010705 metallothionein-3
Graphical View of Protein Domain Structure
References
(Earliest) J:1500 Palmiter RD, et al., MT-III, a brain-specific member of the metallothionein gene family. Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6333-7
(Latest) J:207482 Lee SJ, et al., The role of reciprocal activation of cAbl and Mst1 in the oxidative death of cultured astrocytes. Glia. 2014 Apr;62(4):639-48
All references(48)
Other
accession IDs
MGD-MRK-12575, MGD-MRK-12578

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory