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Mt3 Gene Detail
Summary
  • Symbol
    Mt3
  • Name
    metallothionein 3
  • Synonyms
    MT-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:97173
    NCBI Gene: 17751
  • Gene Overview
    MyGene.info: MT3
Location & Maps
more
  • Sequence Map
    Chr8:94152607-94154148 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1542 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 46.29 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MT3, metallothionein 3
  • Human Ortholog
    MT3, metallothionein 3
    Orthology source: HGNC
  • Synonyms
    GIF, GIFB, GRIF, ZnMT3
  • Links
    NCBI Gene ID: 4504
    neXtProt AC: NX_P25713

  • Chr Location
    16q13; chr16:56589355-56591088 (+)  GRCh38.p2

  • HCOP
    human homology predictions: MT3
  • Gene Tree
    Mt3
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Targeted
    3
Mice homozygous for a knock-out allele exhibit a zinc deficiency in several brain regions, abnormal astrocyte morphology, increased susceptibility to kainic acid induced seizures, and altered zinc accumulation and neuronal death in certain brain areas following seizure-induced or acute brain injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17751 NCBI Gene Model | MGI Sequence Detail 1542 C57BL/6J ±  kb
transcript NM_013603 RefSeq | MGI Sequence Detail 538 C57BL/6  
polypeptide P28184 UniProt | EBI | MGI Sequence Detail 68 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
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  • All nucleic 41
    Genomic 2
    cDNA 36
    Primer pair 2
    Other 1

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-12575, MGD-MRK-12578
References
more
  • Summaries
    All 46
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:1500 Palmiter RD, et al., MT-III, a brain-specific member of the metallothionein gene family. Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6333-7
  • Latest
    J:219983 Artells E, et al., In vivo-folded metal-metallothionein 3 complexes reveal the Cu-thionein rather than Zn-thionein character of this brain-specific mammalian metallothionein. FEBS J. 2014 Mar;281(6):1659-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory