Mt1 MGI Mouse Gene Detail - MGI:97171

Symbol

Mt1
Name

metallothionein 1
Synonyms

Mt-1, MT-I

Feature Type

protein coding gene
IDs

MGI:97171
NCBI Gene: 17748
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:94905710-94906955 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 46.34 cM
Mapping Data

36 experiments

SNPs within 2kb

42 from dbSNP Build 142
Strain Annotations

18
RFLP

8

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97171	protein coding gene	Chr8:94905214-94906955 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033957	protein coding gene	Chr8:95580879-95582115 (+)
A/J	MGP_AJ_G0033940	protein coding gene	Chr8:91861425-91862661 (+)
AKR/J	MGP_AKRJ_G0033866	protein coding gene	Chr8:94381327-94382563 (+)
BALB/cJ	MGP_BALBcJ_G0033932	protein coding gene	Chr8:91951854-91953090 (+)
C3H/HeJ	MGP_C3HHeJ_G0033642	protein coding gene	Chr8:95083243-95084479 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034453	protein coding gene	Chr8:99076169-99077405 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031394	protein coding gene	Chr8:85668422-85669644 (+)
CAST/EiJ	MGP_CASTEiJ_G0032974	protein coding gene	Chr8:94674813-94676049 (+)
CBA/J	MGP_CBAJ_G0033618	protein coding gene	Chr8:102365663-102366899 (+)
DBA/2J	MGP_DBA2J_G0033772	protein coding gene	Chr8:91331369-91332605 (+)
FVB/NJ	MGP_FVBNJ_G0033719	protein coding gene	Chr8:90297402-90298638 (+)
LP/J	MGP_LPJ_G0033864	protein coding gene	Chr8:95732337-95733573 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033761	protein coding gene	Chr8:104665611-104666847 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034471	protein coding gene	Chr8:94538783-94540019 (+)
PWK/PhJ	MGP_PWKPhJ_G0032676	protein coding gene	Chr8:90694731-90695967 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032513	protein coding gene	Chr8:93363766-93365003 (+)
WSB/EiJ	MGP_WSBEiJ_G0033086	protein coding gene	Chr8:95056712-95057948 (+)

Human Ortholog

MT1A, metallothionein 1A

Vertebrate Orthologs

12

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MT1A, metallothionein 1A
Synonyms

MT1, MT-1A, MT1S, MTC, MT-IA
Links

HGNC:7393

NCBI Gene ID: 4489

neXtProt AC: NX_P04731

UniProt: P04731
Chr Location

16q13; chr16:56638666-56640087 (+) GRCh38

Human Ortholog

MT1B, metallothionein 1B
Synonyms

MT1, MT-1B, MT1Q, MT-IB, MTP
Links

HGNC:7394

NCBI Gene ID: 4490

neXtProt AC: NX_P07438

UniProt: P07438
Chr Location

16q13; chr16:56651886-56653204 (+) GRCh38

Human Ortholog

MT1E, metallothionein 1E
Synonyms

MT1, MT-1E, MTD, MT-IE
Links

HGNC:7397

NCBI Gene ID: 4493

neXtProt AC: NX_P04732

UniProt: P04732
Chr Location

16q13; chr16:56625475-56627112 (+) GRCh38

Human Ortholog

MT1F, metallothionein 1F
Synonyms

MT1
Links

HGNC:7398

NCBI Gene ID: 4494

neXtProt AC: NX_P04733

UniProt: P04733
Chr Location

16q13; chr16:56657731-56660698 (+) GRCh38

Human Ortholog

MT1G, metallothionein 1G
Synonyms

MT1, MT1K
Links

HGNC:7399

NCBI Gene ID: 4495

neXtProt AC: NX_P13640

UniProt: P13640
Chr Location

16q13; chr16:56666730-56668065 (-) GRCh38

Human Ortholog

MT1H, metallothionein 1H
Synonyms

MT-0, MT1, MT-1H, MT-IH
Links

HGNC:7400

NCBI Gene ID: 4496

neXtProt AC: NX_P80294

UniProt: P80294
Chr Location

16q13; chr16:56669814-56671129 (+) GRCh38

Human Ortholog

MT1L, metallothionein 1L (pseudogene)
Synonyms

MT1, MT1R, MTF
Links

HGNC:7404

NCBI Gene ID: 4500
Chr Location

16q13; chr16:56617461-56618818 (+) GRCh38

Human Ortholog

MT1M, metallothionein 1M
Synonyms

MT1, MT1K, MT-1M, MT-IM
Links

HGNC:14296

NCBI Gene ID: 4499

neXtProt AC: NX_Q8N339

UniProt: Q8N339
Chr Location

16q13; chr16:56632659-56633981 (+) GRCh38

Human Ortholog

MT1X, metallothionein 1X
Synonyms

MT1, MT-1l
Links

HGNC:7405

NCBI Gene ID: 4501

neXtProt AC: NX_P80297

UniProt: P80297
Chr Location

16q13; chr16:56682470-56684196 (+) GRCh38

MGI Vertebrate Homology

Mt1 stringent orthology
9 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: MT1A, MT1B, MT1E, MT1F, MT1G, MT1H, MT1L, MT1M, MT1X
Gene Tree

Mt1

Diseases

2 with human MT2A associations

				Human Disease	Mouse Models
				carotid stenosis IDs carotid stenosis DOID:13001 MESH:D016893 NCI:C95804 UMLS_CUI:C0007282
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 2 alleles in 3 genetic backgrounds
88 phenotypes from multigenic genotypes
149 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Endonuclease-mediated

3
Gene trapped

14
Targeted

5
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

49 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit abnormal zinc absorption and abnormal circadian rhythm response to melatonin. Mice homozygous for null alleles of Mt1 and Mt2 exhibit increased sensitivity to xenobiotics and injury with decreased wound healing and abnormal mineral aborption.

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All GO Annotations

34
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1075
Tissues

144
cDNA Data

321
Literature Summary

34

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

44
RefSeq

4
UniProt

4
CCDS

CCDS40438.1

Ensembl

ENSMUSG00000031765 (Evidence)
NCBI Gene

17748

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031765	Ensembl Gene Model \| MGI Sequence Detail	1246	C57BL/6J	± kb
transcript	ENSMUST00000212291	Ensembl \| MGI Sequence Detail	633	Not Applicable
polypeptide	ENSMUSP00000148443	Ensembl \| MGI Sequence Detail	132	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010925 metallothionein-1

(term hierarchy)
PDB

1DFS, 1DFT
InterPro Domains

IPR017854 Metallothionein domain superfamily

IPR023587 Metallothionein domain superfamily, vertebrate

IPR000006 Metallothionein, vertebrate

IPR018064 Metallothionein, vertebrate, metal binding site

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All nucleic 344

Genomic 9

cDNA 322

Primer pair 7

Other 6

Microarray probesets 4

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MGD-MRK-12573, MGD-MRK-12576

Summaries

All 303

Developmental Gene Expression 34

Gene Ontology 10

Phenotypes 149
Earliest

J:6458 Durnam DM, et al., Isolation and characterization of the mouse metallothionein-I gene. Proc Natl Acad Sci U S A. 1980 Nov;77(11):6511-5
Latest

J:325593 Tanaka KI, et al., Exacerbation of Elastase-Induced Emphysema via Increased Oxidative Stress in Metallothionein-Knockout Mice. Biomolecules. 2022 Apr 15;12(4)

TSS for Mt1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78824	Chr8:94905862-94905876 (+)	159 bp
Tssr78825	Chr8:94906433-94906489 (+)	751 bp
Tssr78826	Chr8:94906705-94906712 (+)	999 bp
Tssr78827	Chr8:94906721-94906831 (+)	1,066 bp
Tssr78828	Chr8:94906845-94906884 (+)	1,155 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23