Msn Gene Detail

Summary

• Symbol
  Msn
• Name
  moesin

• Feature Type
  protein coding gene
• IDs
  MGI:97167
  NCBI Gene: 17698
• Alliance
  gene page
• Transcription Start Sites
  58 TSS

Location &
Maps

• Sequence Map
  ChrX:95139651-95212159 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome X, 42.65 cM
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  142 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97167	protein coding gene	ChrX:95139648-95212159 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035923	protein coding gene	ChrX:92465910-92543857 (+)
A/J	MGP_AJ_G0035909	protein coding gene	ChrX:92644516-92716430 (+)
AKR/J	MGP_AKRJ_G0035825	protein coding gene	ChrX:95126963-95204716 (+)
BALB/cJ	MGP_BALBcJ_G0035892	protein coding gene	ChrX:91385287-91460143 (+)
C3H/HeJ	MGP_C3HHeJ_G0035600	protein coding gene	ChrX:92952708-93031693 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036421	protein coding gene	ChrX:95392795-95469256 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033250	protein coding gene	ChrX:90643635-90715231 (+)
CAST/EiJ	MGP_CASTEiJ_G0034887	protein coding gene	ChrX:77461625-77537769 (+)
CBA/J	MGP_CBAJ_G0035576	protein coding gene	ChrX:98284438-98363286 (+)
DBA/2J	MGP_DBA2J_G0035730	protein coding gene	ChrX:91836541-91911063 (+)
FVB/NJ	MGP_FVBNJ_G0035668	protein coding gene	ChrX:91239789-91314368 (+)
LP/J	MGP_LPJ_G0035820	protein coding gene	ChrX:93471375-93548390 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035703	protein coding gene	ChrX:102555128-102630295 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036448	protein coding gene	ChrX:92200037-92274176 (+)
PWK/PhJ	MGP_PWKPhJ_G0034586	protein coding gene	ChrX:75116551-75191254 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034415	protein coding gene	ChrX:78282162-78363884 (+)
WSB/EiJ	MGP_WSBEiJ_G0035026	protein coding gene	ChrX:91036791-91114085 (+)

Homology

• Human Ortholog
  MSN, moesin

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  MSN, moesin
  
• Synonyms
  HEL70, IMD50
• Links
  HGNC:7373

  NCBI Gene ID: 4478

  neXtProt AC: NX_P26038

  UniProt: P26038

  
  
• Chr Location
  Xq12; chrX:65588382-65741931 (+)  GRCh38.p7

---

• Alliance of Genome Resources
  Msn stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: MSN
• Protein SuperFamily
  ERM
• Gene Tree
  Msn
  

Human Diseases

• Diseases
  1 with human MSN associations

				Human Disease	Mouse Models
				immunodeficiency 50 IDs immunodeficiency 50       DOID:0112001 OMIM:300988 ORDO:504530

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  12 phenotypes from 2 alleles in 2 genetic backgrounds
  21 phenotype references
  

• All Mutations and Alleles
  22
• Endonuclease-mediated
  3
• Gene trapped
  14
• Targeted
  5
• Find Mice (IMSR)
  22 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Homozygous female and hemizygous male mutant mice develop normally and are fertile. No obvious histological abnormalities are reported.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  63
• GO References
  13

Expression

• Assay Results
  1052
• Tissues
  56
• cDNA Data
  248
• Literature Summary
  22

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase msn

Interactions

• Msn interacts with 250 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

Sequences &
Gene Models

• All Sequences
  65
• RefSeq
  2
• UniProt
  4
• CCDS
  CCDS53139.1

• Ensembl
  ENSMUSG00000031207 (Evidence)
• NCBI Gene
  17698

Representative Sequences			Length	Strain/Species
genomic	17698	NCBI Gene Model | MGI Sequence Detail	72509	C57BL/6J
transcript	NM_010833	RefSeq | MGI Sequence Detail	3840	Not Specified
polypeptide	P26041	UniProt | EBI | MGI Sequence Detail	577	Not Applicable

Protein
Information

• UniProt
  4 Sequences
• Protein Ontology
  PR:000003008 moesin
  (term hierarchy)
• PDB
  4YL8
• InterPro Domains
  IPR019749 Band 4.1 domain
  IPR041789 ERM family, FERM domain C-lobe
  IPR011174 Ezrin/radixin/moesin
  IPR000798 Ezrin/radixin/moesin-like
  IPR014352 FERM/acyl-CoA-binding protein superfamily
  IPR019748 FERM central domain
  IPR019747 FERM conserved site
  IPR018980 FERM, C-terminal PH-like domain
  IPR000299 FERM domain
  IPR018979 FERM, N-terminal
  IPR035963 FERM superfamily, second domain
  IPR008954 Moesin tail domain superfamily
  IPR011993 PH-like domain superfamily
  IPR029071 Ubiquitin-like domain superfamily

Molecular
Reagents

• All nucleic 254

  cDNA 250

  Primer pair 1

  Other 3

  
  

  Microarray probesets 4

Other
Accession IDs

MGD-MRK-12566, MGI:2148057

References

• Summaries
  All 91

  Developmental Gene Expression 22

  Gene Ontology 13

  Phenotypes 21
• Earliest
  J:2811 Sato N, et al., A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites. J Cell Sci. 1992 Sep;103(Pt 1):131-43
• Latest
  J:319663 Satooka H, et al., The ERM protein moesin regulates natural killer cell homeostasis in vivo. Cell Immunol. 2022 Jan;371:104456

TSS for Msn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161502	ChrX:95139598-95139609 (+)	-47 bp
Tssr161503	ChrX:95139613-95139622 (+)	-33 bp
Tssr161504	ChrX:95139640-95139662 (+)	0 bp
Tssr161505	ChrX:95139664-95139683 (+)	23 bp
Tssr161506	ChrX:95139688-95139722 (+)	54 bp
Tssr161507	ChrX:95139723-95139734 (+)	78 bp
Tssr161508	ChrX:95141136-95141141 (+)	1,488 bp
Tssr161509	ChrX:95141428-95141432 (+)	1,779 bp
Tssr161510	ChrX:95143065-95143071 (+)	3,417 bp
Tssr161512	ChrX:95155688-95155704 (+)	16,045 bp
Tssr161513	ChrX:95155799-95155816 (+)	16,157 bp
Tssr161514	ChrX:95159031-95159050 (+)	19,390 bp
Tssr161515	ChrX:95159442-95159466 (+)	19,803 bp
Tssr161516	ChrX:95196149-95196234 (+)	56,541 bp
Tssr161517	ChrX:95196301-95196370 (+)	56,685 bp
Tssr161518	ChrX:95196494-95196498 (+)	56,845 bp
Tssr161519	ChrX:95199057-95199107 (+)	59,431 bp
Tssr161520	ChrX:95199151-95199194 (+)	59,522 bp
Tssr161521	ChrX:95203689-95203743 (+)	64,065 bp
Tssr161522	ChrX:95203747-95203788 (+)	64,117 bp
Tssr161523	ChrX:95207035-95207063 (+)	67,398 bp
Tssr161524	ChrX:95207370-95207387 (+)	67,728 bp
Tssr161525	ChrX:95208974-95209011 (+)	69,342 bp
Tssr161526	ChrX:95209568-95209580 (+)	69,923 bp
Tssr161527	ChrX:95209644-95209660 (+)	70,001 bp
Tssr161528	ChrX:95209667-95209680 (+)	70,023 bp
Tssr161529	ChrX:95209696-95209711 (+)	70,053 bp
Tssr161530	ChrX:95210072-95210084 (+)	70,427 bp
Tssr161531	ChrX:95210090-95210101 (+)	70,445 bp
Tssr161532	ChrX:95210157-95210170 (+)	70,513 bp
Tssr161533	ChrX:95210171-95210180 (+)	70,525 bp
Tssr161534	ChrX:95210195-95210206 (+)	70,550 bp
Tssr161535	ChrX:95210224-95210235 (+)	70,579 bp
Tssr161536	ChrX:95210239-95210250 (+)	70,594 bp
Tssr161537	ChrX:95210373-95210398 (+)	70,735 bp
Tssr161538	ChrX:95210406-95210447 (+)	70,776 bp
Tssr161539	ChrX:95210486-95210512 (+)	70,848 bp
Tssr161540	ChrX:95210546-95210561 (+)	70,903 bp
Tssr161541	ChrX:95210676-95210690 (+)	71,032 bp
Tssr161542	ChrX:95210758-95210769 (+)	71,113 bp
Tssr161543	ChrX:95210852-95210861 (+)	71,206 bp
Tssr161544	ChrX:95210872-95210886 (+)	71,228 bp
Tssr161545	ChrX:95210951-95210962 (+)	71,306 bp
Tssr161546	ChrX:95210974-95210985 (+)	71,329 bp
Tssr161547	ChrX:95210998-95211019 (+)	71,358 bp
Tssr161548	ChrX:95211038-95211049 (+)	71,393 bp
Tssr161549	ChrX:95211103-95211127 (+)	71,464 bp
Tssr161550	ChrX:95211157-95211169 (+)	71,512 bp
Tssr161551	ChrX:95211171-95211217 (+)	71,543 bp
Tssr161552	ChrX:95211333-95211346 (+)	71,689 bp
Tssr161553	ChrX:95211414-95211502 (+)	71,807 bp
Tssr161554	ChrX:95211509-95211526 (+)	71,867 bp
Tssr161555	ChrX:95211568-95211579 (+)	71,923 bp
Tssr161556	ChrX:95211599-95211614 (+)	71,956 bp
Tssr161557	ChrX:95211629-95211640 (+)	71,984 bp
Tssr161558	ChrX:95211998-95212011 (+)	72,354 bp
Tssr161559	ChrX:95212029-95212059 (+)	72,393 bp
Tssr161560	ChrX:95212063-95212076 (+)	72,419 bp