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Msn Gene Detail
Summary
  • Symbol
    Msn
  • Name
    moesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:97167
    NCBI Gene: 17698
  • Gene Overview
    MyGene.info: MSN
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:96096045-96168553 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 42.65 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    143 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97167
 protein coding gene ChrX:96096042-96168553 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035923
 protein coding gene ChrX:92465910-92543857 (+)
A/J MGP_AJ_G0035909
 protein coding gene ChrX:92644516-92716430 (+)
AKR/J MGP_AKRJ_G0035825
 protein coding gene ChrX:95126963-95204716 (+)
BALB/cJ MGP_BALBcJ_G0035892
 protein coding gene ChrX:91385287-91460143 (+)
C3H/HeJ MGP_C3HHeJ_G0035600
 protein coding gene ChrX:92952708-93031693 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036421
 protein coding gene ChrX:95392795-95469256 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033250
 protein coding gene ChrX:90643635-90715231 (+)
CAST/EiJ MGP_CASTEiJ_G0034887
 protein coding gene ChrX:77461625-77537769 (+)
CBA/J MGP_CBAJ_G0035576
 protein coding gene ChrX:98284438-98363286 (+)
DBA/2J MGP_DBA2J_G0035730
 protein coding gene ChrX:91836541-91911063 (+)
FVB/NJ MGP_FVBNJ_G0035668
 protein coding gene ChrX:91239789-91314368 (+)
LP/J MGP_LPJ_G0035820
 protein coding gene ChrX:93471375-93548390 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035703
 protein coding gene ChrX:102555128-102630295 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036448
 protein coding gene ChrX:92200037-92274176 (+)
PWK/PhJ MGP_PWKPhJ_G0034586
 protein coding gene ChrX:75116551-75191254 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034415
 protein coding gene ChrX:78282162-78363884 (+)
WSB/EiJ MGP_WSBEiJ_G0035026
 protein coding gene ChrX:91036791-91114085 (+)



Homology
more
  • Human Ortholog
    MSN, moesin
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MSN, moesin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL70, IMD50
  • Links
    NCBI Gene ID: 4478
    neXtProt AC: NX_P26038
    UniProt: P26038

  • Chr Location
    Xq12; chrX:65588382-65741931 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human MSN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous female and hemizygous male mutant mice develop normally and are fertile. No obvious histological abnormalities are reported.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    980
  • Tissues
    29
  • cDNA Data
    248
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17698 NCBI Gene Model | MGI Sequence Detail 72509 C57BL/6J ±  kb
    transcript NM_010833 RefSeq | MGI Sequence Detail 3840 Not Specified  
    polypeptide P26041 UniProt | EBI | MGI Sequence Detail 577 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 254
      cDNA 250
      Primer pair 1
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12566, MGI:2148057
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 19
      Gene Ontology 12
      Phenotypes 17
    • Earliest
      J:2811 Sato N, et al., A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites. J Cell Sci. 1992 Sep;103(Pt 1):131-43
    • Latest
      J:294771 Lantz B, et al., Finding the Unicorn, a New Mouse Model of Midfacial Clefting. Genes (Basel). 2020 Jan 11;11(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    02/23/2021
    MGI 6.16     		The Jackson Laboratory