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Msn Gene Detail
Summary
  • Symbol
    Msn
  • Name
    moesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:97167
    NCBI Gene: 17698
  • Gene Overview
    MyGene.info: MSN
Location & Maps
more
  • Sequence Map
    ChrX:96096042-96168552 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      72511 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 42.65 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MSN, moesin
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MSN, moesin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL70, IMD50
  • Links
    NCBI Gene ID: 4478
    neXtProt AC: NX_P26038
    UniProt: P26038

  • Chr Location
    Xq12; chrX:65588382-65741931 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotype references
Homozygous female and hemizygous male mutant mice develop normally and are fertile. No obvious histological abnormalities are reported.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    57
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    342
  • Tissues
    22
  • cDNA Data
    247
  • Literature Summary
    10
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018161 VEGA Gene Model | MGI Sequence Detail 72511 C57BL/6J ±  kb
transcript OTTMUST00000043870 VEGA | MGI Sequence Detail 3842 Not Applicable  
polypeptide OTTMUSP00000019702 VEGA | MGI Sequence Detail 577 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    143 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 252
    cDNA 249
    Primer pair 1
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-12566, MGI:2148057
References
more
  • Summaries
    All 60
    Developmental Gene Expression 10
    Gene Ontology 10
    Phenotypes 15
  • Earliest
    J:2811 Sato N, et al., A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites. J Cell Sci. 1992 Sep;103(Pt 1):131-43
  • Latest
    J:240513 Schierwagen R, et al., Statins improve NASH via inhibition of RhoA and Ras. Am J Physiol Gastrointest Liver Physiol. 2016 Oct 01;311(4):G724-G733
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
08/08/2017
MGI 6.10 		The Jackson Laboratory