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Msmb Gene Detail
Summary
  • Symbol
    Msmb
  • Name
    beta-microseminoprotein
  • Synonyms
    beta-inhibin, beta-MSP, PIP, prostatic inhibin protein, PSP94
  • Feature Type
    protein coding gene
  • IDs
    MGI:97166
    NCBI Gene: 17695
  • Gene Overview
    MyGene.info: MSMB
Location & Maps
more
  • Sequence Map
    Chr14:32142026-32158370 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16345 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 19.40 cM, cytoband B
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MSMB, microseminoprotein beta
  • Vertebrate Orthologs
    5
  • Human Ortholog
    MSMB, microseminoprotein beta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HPC13, IGBF, MSP, MSPB, PN44, PRPS, PSP, PSP57, PSP94, PSP-94
  • Links
    NCBI Gene ID: 4477
    neXtProt AC: NX_P08118

  • Chr Location
    10q11.2; chr10:46033305-46046269 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Msmb mouse models; 1 with human MSMB associations

Human Disease Mouse Models
       Prostate Cancer   OMIM: 176807 View 1 model
       Prostate Cancer, Hereditary, 13; HPC13   OMIM: 611928
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    37
  • Gene trapped
    33
  • Targeted
    4
Mice homozygous for a knock-in allele exhibit early prostate cancer development progressing from intraepithelial neoplasia with microinvasion to well-differentiated prostate gland adenocarcinoma, and show enlargement of the prostate gland and the lymph nodes, and increased metastatic potential.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032536 VEGA Gene Model | MGI Sequence Detail 16345 C57BL/6J ±  kb
transcript OTTMUST00000081023 VEGA | MGI Sequence Detail 537 Not Applicable  
polypeptide OTTMUSP00000043259 VEGA | MGI Sequence Detail 120 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    68 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010678 beta-microseminoprotein
  • InterPro Domains
    IPR008735 Beta-microseminoprotein
Molecular
Reagents
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  • All nucleic 4
    cDNA 1
    Primer pair 1
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12565
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 1
    Phenotypes 13
  • Earliest
    J:434 Ulvsback M, et al., Assignment of the human gene for beta-microseminoprotein (MSMB) to chromosome 10 and demonstration of related genes in other vertebrates. Genomics. 1991 Dec;11(4):920-4
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory