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Msmb
Gene Detail
Symbol

Name
ID
Msmb
beta-microseminoprotein
MGI:97166
Synonyms
beta-inhibin, beta-MSP, PIP, prostatic inhibin protein, PSP94
Feature Type
protein coding gene
Genetic Map
Chromosome 14
19.40 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:32142026-32158370 bp, + strand
From VEGA annotation of GRCm38

  16345 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1832  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Protein SuperFamily: beta-microseminoprotein
Gene Tree: Msmb

Human
homologs
Human Homolog MSMB, microseminoprotein, beta-
NCBI Gene ID 4477
neXtProt AC  NX_P08118
Human Synonyms  HPC13, IGBF, MSP, MSPB, PN44, PRPS, PSP, PSP57, PSP94, PSP-94
Human Chr (Location)  10q11.2; chr10:46033305-46046269 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MSMB
Mutations,
alleles, and
phenotypes
All mutations/alleles(36) : Gene trapped(33) Targeted(3)
 
Mice homozygous for a knock-in allele exhibit early prostate cancer development progressing from intraepithelial neoplasia with microinvasion to well-differentiated prostate gland adenocarcinoma, and show enlargement of the prostate gland and the lymph nodes, and increased metastatic potential.
 
Human Diseases Modeled Using Mouse Msmb (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Msmb interacts with 29 markers (Mir100, Mir125a, Mir143, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process biological_process
Component extracellular region
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (9)    Tissues (3)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 9
cDNA source data(1)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(4) cDNA(1) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000032536 (Evidence)
Ensembl Gene ModelENSMUSG00000021907 (Evidence)
Entrez Gene17695 (Evidence)
UniGene2540
DFCITC1585070
DoTSDT.91333917
NIA Mouse Gene IndexU015472
Consensus CDS ProjectCCDS36862.1
International Mouse Knockout Project StatusMsmb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032536 VEGA Gene Model | MGI Sequence Detail 16345 C57BL/6J ±  kb
transcript OTTMUST00000081023 VEGA | MGI Sequence Detail 537 Not Applicable 
polypeptide OTTMUSP00000043259 VEGA | MGI Sequence Detail 120 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008735 Beta-microseminoprotein
Protein Ontology PR:000010678 beta-microseminoprotein
References
(Earliest) J:434 Ulvsback M, et al., Assignment of the human gene for beta-microseminoprotein (MSMB) to chromosome 10 and demonstration of related genes in other vertebrates. Genomics. 1991 Dec;11(4):920-4
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(35)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12565

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory