Msmb
Gene Detail

Symbol Name ID

Msmb beta-microseminoprotein MGI:97166

Synonyms

beta-inhibin, beta-MSP, PIP, prostatic inhibin protein, PSP94

Feature Type

protein coding gene

Genetic Map

Chromosome 14

19.40 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr14:32142026-32158370 bp, + strand From VEGA annotation of GRCm38   16345 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1832  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Protein SuperFamily: beta-microseminoprotein
Gene Tree: Msmb

Human homologs

Human Homolog		MSMB, microseminoprotein, beta-
NCBI Gene ID		4477
neXtProt AC		NX_P08118
Human Synonyms		HPC13, IGBF, MSP, MSPB, PN44, PRPS, PSP, PSP57, PSP94, PSP-94
Human Chr (Location)		10q11.2; chr10:51549553-51562517 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MSMB

Alleles and phenotypes

All alleles(36) : Targeted(3) Gene trapped(33)
 

Mice homozygous for a knock-in allele exhibit early prostate cancer development progressing from intraepithelial neoplasia with microinvasion to well-differentiated prostate gland adenocarcinoma, and show enlargement of the prostate gland and the lymph nodes, and increased metastatic potential.

 
Human Diseases Modeled Using Mouse Msmb (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (3 annotations)

Process	biological_process
Component	extracellular region
Function	molecular_function

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (9)    Tissues (3)    Images (2)
Theiler Stages: 28

Assay Type	Results
RT-PCR	9

cDNA source data(1)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(4) cDNA(1) Primer pair(1) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000032536 (Evidence)
Ensembl Gene Model	ENSMUSG00000021907 (Evidence)
Entrez Gene	17695 (Evidence)
UniGene	2540
DFCI	TC1585070
DoTS	DT.91333917
NIA Mouse Gene Index	U015472
Consensus CDS Project	CCDS36862.1
International Mouse Knockout Project Status	Msmb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000032536	VEGA Gene Model | MGI Sequence Detail	16345	C57BL/6J
transcript	OTTMUST00000081023	VEGA | MGI Sequence Detail	537	Not Applicable
polypeptide	OTTMUSP00000043259	VEGA | MGI Sequence Detail	120	Not Applicable

All sequences(26) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(62 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008735	Beta-microseminoprotein
Protein Ontology	PR:000010678	beta-microseminoprotein

References

(Earliest) J:434 Ulvsback M, et al., Assignment of the human gene for beta-microseminoprotein (MSMB) to chromosome 10 and demonstration of related genes in other vertebrates. Genomics. 1991 Dec;11(4):920-4
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(35)

Other accession IDs

MGD-MRK-12565