Mpi
Gene Detail

Symbol Name ID

Mpi mannose phosphate isomerase MGI:97075

Synonyms

1110002E17Rik, Mpi1, Mpi-1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

31.05 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(46)

Sequence Map

Chr9:57544256-57552763 bp, - strand From VEGA annotation of GRCm38   8508 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1825  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: mannose-6-phosphate isomerase
Gene Tree: Mpi

Human homologs

Human Homolog		MPI, mannose phosphate isomerase
NCBI Gene ID		4351
neXtProt AC		NX_P34949
Human Synonyms		CDG1B, PMI, PMI1
Human Chr (Location)		15q22-qter; chr15:75182410-75190565 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MPI

Alleles and phenotypes

All alleles(11) : Targeted(3) Gene trapped(8)
 

Homozygous null mice display embryonic lethality during organogenesis, variable abnormalities of the yolk sac and embryonic vasculature, and partial penetrance of abnormal chorioallantoic fusion, placental defects, impaired emrbyo turning, increased apoptosis, and posterior axial truncations.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	carbohydrate metabolic process, GDP-mannose biosynthetic process, ...
Component	cytoplasm
Function	isomerase activity, mannose-6-phosphate isomerase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(74)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(75) cDNA(75)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000033819 (Evidence)
Ensembl Gene Model	ENSMUSG00000032306 (Evidence)
Entrez Gene	110119 (Evidence)
UniGene	247218
DFCI	TC1576116
DoTS	DT.491557
NIA Mouse Gene Index	U076834
EC	5.3.1.8
Consensus CDS Project	CCDS40650.1
International Mouse Knockout Project Status	Mpi

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033819	VEGA Gene Model | MGI Sequence Detail	8508	C57BL/6J
transcript	OTTMUST00000085193	VEGA | MGI Sequence Detail	1780	Not Applicable
polypeptide	OTTMUSP00000045991	VEGA | MGI Sequence Detail	423	Not Applicable

All sequences(38) RefSeq(3) UniProt(4)

Polymorphisms

SNPs(24 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016305	Mannose-6-phosphate isomerase
InterPro	IPR001250	Mannose-6-phosphate isomerase, type I
InterPro	IPR018050	Phosphomannose isomerase, type I, conserved site
InterPro	IPR011051	RmlC-like cupin domain
InterPro	IPR014710	RmlC-like jelly roll fold
Protein Ontology	PR:000010540	mannose-6-phosphate isomerase

References

(Earliest) J:5334 Nichols EA, et al., Polymorphism and linkage for mannosephosphate isomerase in Mus musculus. Biochem Genet. 1973 Jan;8(1):47-53
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(91)

Other accession IDs

MGD-MRK-12407, MGD-MRK-12408, MGI:1914159, MGI:2143013