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Mpi
Gene Detail
Symbol

Name
ID
Mpi
mannose phosphate isomerase
MGI:97075
Synonyms
1110002E17Rik, Mpi1, Mpi-1
Feature Type
protein coding gene
Genetic Map
Chromosome 9
31.05 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(46)
Sequence Map
Chr9:57544256-57552763 bp, - strand
From VEGA annotation of GRCm38

  8508 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1825  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MPI
Protein SuperFamily: mannose-6-phosphate isomerase
Gene Tree: Mpi

Human
homologs
MPI, mannose phosphate isomerase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4351
neXtProt AC: NX_P34949

Human Synonyms: CDG1B, PMI, PMI1

Human Chr (Location): 15q24.1; chr15:74890011-74899457 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MPI

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(8) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display embryonic lethality during organogenesis, variable abnormalities of the yolk sac and embryonic vasculature, and partial penetrance of abnormal chorioallantoic fusion, placental defects, impaired emrbyo turning, increased apoptosis, and posterior axial truncations.
 
Interactions
Mpi interacts with 75 markers (Mir16-1, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process carbohydrate metabolic process, GDP-mannose biosynthetic process, ...
Component cytoplasm, extracellular exosome
Function isomerase activity, mannose-6-phosphate isomerase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(74)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mpi ; ZFIN mpi    NEW 
Molecular
reagents
All nucleic(75) cDNA(75)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000033819 (Evidence)
Ensembl Gene Model ENSMUSG00000032306 (Evidence)
Entrez Gene 110119 (Evidence)
UniGene 247218
DFCI TC1576116
DoTS DT.491557
NIA Mouse Gene Index U076834
EC 5.3.1.8
Consensus CDS Project CCDS40650.1
International Mouse Phenotyping Consortium Status Mpi
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033819 VEGA Gene Model | MGI Sequence Detail 8508 C57BL/6J ±  kb
transcript OTTMUST00000085193 VEGA | MGI Sequence Detail 1780 Not Applicable 
polypeptide OTTMUSP00000045991 VEGA | MGI Sequence Detail 423 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(9) UniProt(4)
Polymorphisms
SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016305 Mannose-6-phosphate isomerase
InterPro IPR001250 Mannose-6-phosphate isomerase, type I
InterPro IPR018050 Phosphomannose isomerase, type I, conserved site
InterPro IPR011051 RmlC-like cupin domain
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000010540 mannose-6-phosphate isomerase
References
(Earliest) J:5334 Nichols EA, et al., Polymorphism and linkage for mannosephosphate isomerase in Mus musculus. Biochem Genet. 1973 Jan;8(1):47-53
(Latest) J:202966 Harada Y, et al., Metabolically programmed quality control system for dolichol-linked oligosaccharides. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19366-71
All references(83)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12407, MGD-MRK-12408, MGI:1914159, MGI:2143013

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory