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Mpi Gene Detail
Summary
  • Symbol
    Mpi
  • Name
    mannose phosphate isomerase
  • Synonyms
    1110002E17Rik, Mpi1, Mpi-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97075
    NCBI Gene: 110119
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:57451539-57460046 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 31.05 cM, cytoband C
  • Mapping Data
    46 experiments
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97075
protein coding gene Chr9:57448744-57460095 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034869
protein coding gene Chr9:56758815-56767324 (-)
A/J MGP_AJ_G0034850
protein coding gene Chr9:54929210-54937900 (-)
AKR/J MGP_AKRJ_G0034779
protein coding gene Chr9:56190457-56198959 (-)
BALB/cJ MGP_BALBcJ_G0034842
protein coding gene Chr9:54714203-54722710 (-)
C3H/HeJ MGP_C3HHeJ_G0034552
protein coding gene Chr9:56675676-56684184 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035361
protein coding gene Chr9:58341842-58350342 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032272
protein coding gene Chr9:54235080-54243382 (-)
CAST/EiJ MGP_CASTEiJ_G0033873
protein coding gene Chr9:56763878-56772352 (-)
CBA/J MGP_CBAJ_G0034523
protein coding gene Chr9:60379546-60388057 (-)
DBA/2J MGP_DBA2J_G0034682
protein coding gene Chr9:54796875-54805387 (-)
FVB/NJ MGP_FVBNJ_G0034624
protein coding gene Chr9:54022916-54034537 (-)
LP/J MGP_LPJ_G0034765
protein coding gene Chr9:57055914-57064424 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034667
protein coding gene Chr9:61877676-61886189 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035383
protein coding gene Chr9:56212046-56220550 (-)
PWK/PhJ MGP_PWKPhJ_G0033578
protein coding gene Chr9:54826126-54834604 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033412
protein coding gene Chr9:56502252-56510816 (-)
WSB/EiJ MGP_WSBEiJ_G0033986
protein coding gene Chr9:56145014-56153823 (-)



Homology
more
  • Human Ortholog
    MPI, mannose phosphate isomerase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MPI, mannose phosphate isomerase
  • Synonyms
    CDG1B, PMI, PMI1
  • Links
    NCBI Gene ID: 4351
    neXtProt AC: NX_P34949
    UniProt: P34949

  • Chr Location
    15q24.1-q24.2; chr15:74890005-74902219 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human MPI associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality during organogenesis, variable abnormalities of the yolk sac and embryonic vasculature, and partial penetrance of abnormal chorioallantoic fusion, placental defects, impaired emrbyo turning, increased apoptosis, and posterior axial truncations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032306 Ensembl Gene Model | MGI Sequence Detail 8508 C57BL/6J ±  kb
    transcript ENSMUST00000034856 Ensembl | MGI Sequence Detail 1780 Not Applicable  
    polypeptide ENSMUSP00000034856 Ensembl | MGI Sequence Detail 423 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000010540 mannose-6-phosphate isomerase
    • EC
    • InterPro Domains
      IPR016305 Mannose-6-phosphate isomerase
      IPR001250 Mannose-6-phosphate isomerase, type I
      IPR046457 Phosphomannose isomerase type I, catalytic domain
      IPR018050 Phosphomannose isomerase, type I, conserved site
      IPR046456 Phosphomannose isomerase type I, C-terminal domain
      IPR046458 Phosphomannose isomerase type I, helical insertion domain
      IPR011051 RmlC-like cupin domain superfamily
      IPR014710 RmlC-like jelly roll fold
    Molecular
    Reagents
    less
    • All nucleic 76
      cDNA 76

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-12407, MGD-MRK-12408, MGI:1914159, MGI:2143013
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 12
      Phenotypes 11
    • Earliest
      J:5334 Nichols EA, et al., Polymorphism and linkage for mannosephosphate isomerase in Mus musculus. Biochem Genet. 1973 Jan;8(1):47-53
    • Latest
      J:320423 Sharma V, et al., Mannose supplements induce embryonic lethality and blindness in phosphomannose isomerase hypomorphic mice. FASEB J. 2014 Apr;28(4):1854-69

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory