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Mpi Gene Detail
Summary
  • Symbol
    Mpi
  • Name
    mannose phosphate isomerase
  • Synonyms
    1110002E17Rik, Mpi1, Mpi-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97075
    NCBI Gene: 110119
Location & Maps
more
  • Sequence Map
    Chr9:57544256-57552763 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8508 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 31.05 cM, cytoband C
  • Mapping Data
    46 experiments
Homology
more
  • Human Ortholog
    MPI, mannose phosphate isomerase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MPI, mannose phosphate isomerase
    Orthology source: HomoloGene
  • Synonyms
    CDG1B, PMI, PMI1
  • Links
    NCBI Gene ID: 4351
    neXtProt AC: NX_P34949

  • Chr Location
    15q24.1; chr15:74890011-74899457 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Mpi mouse models; 1 with human MPI associations

Human Disease Mouse Models
       Congenital Disorder of Glycosylation, Type IB; CDG1B   OMIM: 602579 View 1 "NOT" model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality during organogenesis, variable abnormalities of the yolk sac and embryonic vasculature, and partial penetrance of abnormal chorioallantoic fusion, placental defects, impaired emrbyo turning, increased apoptosis, and posterior axial truncations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033819 VEGA Gene Model | MGI Sequence Detail 8508 C57BL/6J ±  kb
transcript OTTMUST00000085193 VEGA | MGI Sequence Detail 1780 Not Applicable  
polypeptide OTTMUSP00000045991 VEGA | MGI Sequence Detail 423 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    26 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010540 mannose-6-phosphate isomerase
  • EC
  • InterPro Domains
    IPR016305 Mannose-6-phosphate isomerase
    IPR001250 Mannose-6-phosphate isomerase, type I
    IPR018050 Phosphomannose isomerase, type I, conserved site
    IPR011051 RmlC-like cupin domain
    IPR014710 RmlC-like jelly roll fold
Molecular
Reagents
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  • All nucleic 75
    cDNA 75

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-12407, MGD-MRK-12408, MGI:1914159, MGI:2143013
References
more
  • Summaries
    All 80
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 11
    Phenotypes 8
  • Earliest
    J:5334 Nichols EA, et al., Polymorphism and linkage for mannosephosphate isomerase in Mus musculus. Biochem Genet. 1973 Jan;8(1):47-53
  • Latest
    J:202966 Harada Y, et al., Metabolically programmed quality control system for dolichol-linked oligosaccharides. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19366-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory