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Mov10 Gene Detail
Summary
  • Symbol
    Mov10
  • Name
    Mov10 RISC complex RNA helicase
  • Synonyms
    Mov-10
  • Feature Type
    protein coding gene
  • IDs
    MGI:97054
    NCBI Gene: 17454
  • Gene Overview
    MyGene.info: MOV10
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:104794836-104818563 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 45.87 cM, cytoband F2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    95 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97054
protein coding gene Chr3:104794828-104818595 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027711
protein coding gene Chr3:106118180-106139348 (-)
A/J MGP_AJ_G0027671
protein coding gene Chr3:102736772-102758707 (-)
AKR/J MGP_AKRJ_G0027636
protein coding gene Chr3:105262939-105285878 (-)
BALB/cJ MGP_BALBcJ_G0027683
protein coding gene Chr3:102521770-102544835 (-)
C3H/HeJ MGP_C3HHeJ_G0027413
protein coding gene Chr3:105644432-105666928 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028127
protein coding gene Chr3:110082142-110107979 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025467
protein coding gene Chr3:98847506-98868092 (-)
CAST/EiJ MGP_CASTEiJ_G0026869
protein coding gene Chr3:104759624-104783528 (-)
CBA/J MGP_CBAJ_G0027388
protein coding gene Chr3:113829112-113856597 (-)
DBA/2J MGP_DBA2J_G0027530
protein coding gene Chr3:101990615-102013305 (-)
FVB/NJ MGP_FVBNJ_G0027498
protein coding gene Chr3:99913170-99934898 (-)
LP/J MGP_LPJ_G0027637
protein coding gene Chr3:107499158-107522106 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027528
protein coding gene Chr3:119952768-119978784 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028182
protein coding gene Chr3:104823235-104844506 (-)
PWK/PhJ MGP_PWKPhJ_G0026595
protein coding gene Chr3:101766704-101788306 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026416
protein coding gene Chr3:102859913-102887583 (-)
WSB/EiJ MGP_WSBEiJ_G0026949
protein coding gene Chr3:105401521-105424087 (-)



Homology
more
  • Human Ortholog
    MOV10, Mov10 RISC complex RNA helicase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MOV10, Mov10 RISC complex RNA helicase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    fSAP113, gb110
  • Links
    NCBI Gene ID: 4343
    neXtProt AC: NX_Q9HCE1
    UniProt: Q9HCE1

  • Chr Location
    1p13.2; chr1:112674312-112702377 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout is embryonic lethal. Heterozygous knockout leads to reduced dendritic branching of neurons, which affects anxiety- and/or activity-related behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002227 Ensembl Gene Model | MGI Sequence Detail 23728 C57BL/6J ±  kb
transcript ENSMUST00000106775 Ensembl | MGI Sequence Detail 3584 Not Applicable  
polypeptide ENSMUSP00000102387 Ensembl | MGI Sequence Detail 1077 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 93
    Genomic 4
    cDNA 89

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-12359, MGD-MRK-12377, MGI:2140051
References
more
  • Summaries
    All 44
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:6514 Jaenisch R, et al., Chromosomal position and activation of retroviral genomes inserted into the germ line of mice. Cell. 1981 May;24(2):519-29
  • Latest
    J:251835 Skariah G, et al., Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain. BMC Biol. 2017 Jun 29;15(1):54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory