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Mos
Gene Detail
Symbol

Name
ID
Mos
Moloney sarcoma oncogene
MGI:97052
Synonyms
c-mos
Feature Type
protein coding gene
Genetic Map
Chromosome 4
2.16 cM, cytoband A1-A2
Detailed Genetic Map ± 1 cM


Mapping data(39)
Sequence Map
Chr4:3870657-3872105 bp, - strand
From VEGA annotation of GRCm38

  1449 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3919  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MOS
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mos

Human
homologs
MOS, v-mos Moloney murine sarcoma viral oncogene homolog
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4342
neXtProt AC: NX_P00540

Human Synonyms: MSV

Human Chr (Location): 8q11; chr8:56112942-56113982 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutations that inactivate the gene result in female infertility and an increased susceptibility to tumors. Oocytes progress through meiosis II without arrest and undergo spontaneous parthenogenetic activation. Male mice are fertile and show no spermatogenic defects.
 
Interactions
Mos interacts with 16 markers (Mir146b, Mir148b, Mir181b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process protein phosphorylation, regulation of meiotic nuclear division
Component cytosol
Function protein serine/threonine kinase activity
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (17)    Tissues (12)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 17
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MOS ; Xenbase mos    NEW 
Molecular
reagents
All nucleic(36) Genomic(21) cDNA(10) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000004409 (Evidence)
Ensembl Gene Model ENSMUSG00000078365 (Evidence)
Entrez Gene 17451 (Evidence)
UniGene 459300
DFCI TC1599671, TC1743486
DoTS DT.101723027, DT.480796
NIA Mouse Gene Index U024807
Consensus CDS Project CCDS38685.1
International Mouse Phenotyping Consortium Status Mos
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004409 VEGA Gene Model | MGI Sequence Detail 1449 C57BL/6J ±  kb
transcript OTTMUST00000009992 VEGA | MGI Sequence Detail 1449 Not Applicable 
polypeptide OTTMUSP00000004784 VEGA | MGI Sequence Detail 343 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(1)
Polymorphisms
All PCR and RFLP(10) : PCR(1) RFLP(9) SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010526 proto-oncogene serine/threonine-protein kinase mos
References
(Earliest) J:6268 Oskarsson M, et al., Properties of a normal mouse cell DNA sequence (sarc) homologous to the src sequence of Moloney sarcoma virus. Science. 1980 Mar 14;207(4436):1222-4
(Latest) J:219727 Chaigne A, et al., A narrow window of cortical tension guides asymmetric spindle positioning in the mouse oocyte. Nat Commun. 2015;6:6027
All references(110)
Other
accession IDs
MGD-MRK-12357

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory