Mos
Gene Detail

Symbol Name ID

Mos Moloney sarcoma oncogene MGI:97052

Synonyms

c-mos

Feature Type

protein coding gene

Genetic Map

Chromosome 4

2.16 cM, cytoband A1-A2
Detailed Genetic Map ± 1 cM


Mapping data(39)

Sequence Map

Chr4:3870657-3872105 bp, - strand From VEGA annotation of GRCm38   1449 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3919  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mos

Human homologs

Human Homolog		MOS, v-mos Moloney murine sarcoma viral oncogene homolog
NCBI Gene ID		4342
neXtProt AC		NX_P00540
Human Synonyms		MSV
Human Chr (Location)		8q11; chr8:57025501-57026541 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mutations that inactivate the gene result in female infertility and an increased susceptibility to tumors. Oocytes progress through meiosis II without arrest and undergo spontaneous parthenogenetic activation. Male mice are fertile and show no spermatogenic defects.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	regulation of meiosis
Component	cytosol
Function	ATP binding, nucleotide binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (21)    Tissues (14)    Images (1)
Theiler Stages: 1, 2, 3, 5, 20, 21, 22, 23, 28

Assay Type	Results
RT-PCR	21

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(36) Genomic(21) cDNA(10) Primer pair(4) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000004409 (Evidence)
Ensembl Gene Model	ENSMUSG00000078365 (Evidence)
Entrez Gene	17451 (Evidence)
UniGene	459300
DFCI	TC1599671, TC1743486
DoTS	DT.101723027, DT.480796
NIA Mouse Gene Index	U024807
Consensus CDS Project	CCDS38685.1
International Mouse Knockout Project Status	Mos

Sequences

Length	Strain/Species
genomic	OTTMUSG00000004409	VEGA Gene Model | MGI Sequence Detail	1449	C57BL/6J
transcript	OTTMUST00000009992	VEGA | MGI Sequence Detail	1449	Not Applicable
polypeptide	OTTMUSP00000004784	VEGA | MGI Sequence Detail	343	Not Applicable

All sequences(26) RefSeq(2) UniProt(1)

Polymorphisms

All PCR and RFLP(10) : PCR(1) RFLP(9) SNPs(26 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000010526	proto-oncogene serine/threonine-protein kinase mos

References

(Earliest) J:6268 Oskarsson M, et al., Properties of a normal mouse cell DNA sequence (sarc) homologous to the src sequence of Moloney sarcoma virus. Science. 1980 Mar 14;207(4436):1222-4
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(111)

Other accession IDs

MGD-MRK-12357