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Mos Gene Detail
Summary
  • Symbol
    Mos
  • Name
    Moloney sarcoma oncogene
  • Synonyms
    c-mos
  • Feature Type
    protein coding gene
  • IDs
    MGI:97052
    NCBI Gene: 17451
  • Gene Overview
    MyGene.info: MOS
Location & Maps
more
  • Genetic Map
    Chromosome 4, 2.16 cM, cytoband A1-A2
  • Mapping Data
    39 experiments
Homology
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  • Human Ortholog
    MOS, v-mos Moloney murine sarcoma viral oncogene homolog
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MOS, v-mos Moloney murine sarcoma viral oncogene homolog
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MSV
  • Links
    NCBI Gene ID: 4342
    neXtProt AC: NX_P00540

  • Chr Location
    8q12.1; chr8:56112942-56113982 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations that inactivate the gene result in female infertility and an increased susceptibility to tumors. Oocytes progress through meiosis II without arrest and undergo spontaneous parthenogenetic activation. Male mice are fertile and show no spermatogenic defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004409 VEGA Gene Model | MGI Sequence Detail 1449 C57BL/6J ±  kb
transcript OTTMUST00000009992 VEGA | MGI Sequence Detail 1449 Not Applicable  
polypeptide OTTMUSP00000004784 VEGA | MGI Sequence Detail 343 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    40 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 36
    Genomic 21
    cDNA 10
    Primer pair 4
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-12357
References
more
  • Summaries
    All 110
    Developmental Gene Expression 10
    Gene Ontology 8
    Phenotypes 20
  • Earliest
    J:6268 Oskarsson M, et al., Properties of a normal mouse cell DNA sequence (sarc) homologous to the src sequence of Moloney sarcoma virus. Science. 1980 Mar 14;207(4436):1222-4
  • Latest
    J:219727 Chaigne A, et al., A narrow window of cortical tension guides asymmetric spindle positioning in the mouse oocyte. Nat Commun. 2015;6:6027

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory