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Mos
Gene Detail
Symbol

Name
ID
Mos
Moloney sarcoma oncogene
MGI:97052
Synonyms
c-mos
Feature Type
protein coding gene
Genetic Map
Chromosome 4
2.16 cM, cytoband A1-A2
Detailed Genetic Map ± 1 cM


Mapping data(39)
Sequence Map
Chr4:3870657-3872105 bp, - strand
From VEGA annotation of GRCm38

  1449 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3919  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mos

Human
homologs
Human Homolog MOS, v-mos Moloney murine sarcoma viral oncogene homolog
NCBI Gene ID 4342
neXtProt AC  NX_P00540
Human Synonyms  MSV
Human Chr (Location)  8q11; chr8:56112942-56113982 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations that inactivate the gene result in female infertility and an increased susceptibility to tumors. Oocytes progress through meiosis II without arrest and undergo spontaneous parthenogenetic activation. Male mice are fertile and show no spermatogenic defects.
 
Interactions
Mos interacts with 16 markers (Mir146b, Mir148b, Mir181b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process protein phosphorylation, regulation of meiosis
Component cytosol
Function protein serine/threonine kinase activity
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (17)    Tissues (12)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 17
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) Genomic(21) cDNA(10) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000004409 (Evidence)
Ensembl Gene ModelENSMUSG00000078365 (Evidence)
Entrez Gene17451 (Evidence)
UniGene459300
DFCITC1599671, TC1743486
DoTSDT.101723027, DT.480796
NIA Mouse Gene IndexU024807
Consensus CDS ProjectCCDS38685.1
International Mouse Knockout Project StatusMos
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004409 VEGA Gene Model | MGI Sequence Detail 1449 C57BL/6J ±  kb
transcript OTTMUST00000009992 VEGA | MGI Sequence Detail 1449 Not Applicable 
polypeptide OTTMUSP00000004784 VEGA | MGI Sequence Detail 343 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms
All PCR and RFLP(10) : PCR(1) RFLP(9) SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010526 proto-oncogene serine/threonine-protein kinase mos
References
(Earliest) J:6268 Oskarsson M, et al., Properties of a normal mouse cell DNA sequence (sarc) homologous to the src sequence of Moloney sarcoma virus. Science. 1980 Mar 14;207(4436):1222-4
(Latest) J:205485 Yu C, et al., CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science. 2013 Dec 20;342(6165):1518-21
All references(112)
Other
accession IDs
MGD-MRK-12357

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory