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Mdh2 Gene Detail
Summary
  • Symbol
    Mdh2
  • Name
    malate dehydrogenase 2, NAD (mitochondrial)
  • Synonyms
    Mdh-2, Mor1, Mor-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97050
    NCBI Gene: 17448
  • Gene Overview
    MyGene.info: MDH2
Location & Maps
more
  • Sequence Map
    Chr5:135778480-135790398 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11919 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 75.40 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    MDH2, malate dehydrogenase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MDH2, malate dehydrogenase 2
    Orthology source: HomoloGene
  • Synonyms
    MDH, MGC:3559, M-MDH, MOR1
  • Links
    NCBI Gene ID: 4191
    neXtProt AC: NX_P40926

  • Chr Location
    7cen-q22; chr7:76048019-76067508 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    18
  • Gene trapped
    14
  • Targeted
    4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022781 VEGA Gene Model | MGI Sequence Detail 11919 C57BL/6J ±  kb
transcript OTTMUST00000054708 VEGA | MGI Sequence Detail 1456 Not Applicable  
polypeptide OTTMUSP00000026139 VEGA | MGI Sequence Detail 338 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    117 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010264 malate dehydrogenase, mitochondrial
  • EC
  • InterPro Domains
    IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
    IPR022383 Lactate/malate dehydrogenase, C-terminal
    IPR001236 Lactate/malate dehydrogenase, N-terminal
    IPR001557 L-lactate/malate dehydrogenase
    IPR001252 Malate dehydrogenase, active site
    IPR010097 Malate dehydrogenase, type 1
    IPR016040 NAD(P)-binding domain
Molecular
Reagents
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  • All nucleic 478
    Genomic 5
    cDNA 470
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-12165, MGD-MRK-12353, MGD-MRK-12355
References
more
  • Summaries
    All 53
    Developmental Gene Expression 3
    Gene Ontology 11
    Phenotypes 9
  • Earliest
    J:5187 Shows TB, et al., Mitochondrial malate dehydrogenase and malic enzyme: Mendelian inherited electrophoretic variants in the mouse. Biochem Genet. 1970 Dec;4(6):707-18
  • Latest
    J:211522 Kim EY, et al., Acceleration of adipogenic differentiation via acetylation of malate dehydrogenase 2. Biochem Biophys Res Commun. 2013 Nov 8;441(1):77-82

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory