About   Help   FAQ
Ndst2 Gene Detail
Summary
  • Symbol
    Ndst2
  • Name
    N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
  • Synonyms
    glucosaminyl N-deacetylase/N-sulphotransferase-2, [Heparan sulfate]-glucosamine N-sulfotransferase, Mndns
  • Feature Type
    protein coding gene
  • IDs
    MGI:97040
    NCBI Gene: 17423
  • Gene Overview
    MyGene.info: NDST2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:20723730-20734562 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10833 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 11.53 cM, cytoband B
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NDST2, N-deacetylase and N-sulfotransferase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NDST2, N-deacetylase and N-sulfotransferase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSST2, NST2
  • Links
    NCBI Gene ID: 8509
    neXtProt AC: NX_P52849
    UniProt: P52849

  • Chr Location
    10q22.2; chr10:73801911-73811831 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozugous for a null allele exhibit reduced mast cell numbers, histamine storage, protease storage and degranulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039308 Ensembl Gene Model | MGI Sequence Detail 10833 C57BL/6J ±  kb
    transcript ENSMUST00000223679 Ensembl | MGI Sequence Detail 3907 Not Applicable  
    polypeptide ENSMUSP00000153036 Ensembl | MGI Sequence Detail 883 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      27 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      Genomic 4
      cDNA 50
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12336
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 27
    • Earliest
      J:17539 Eriksson I, et al., cDNA cloning and sequencing of mouse mastocytoma glucosaminyl N-deacetylase/N-sulfotransferase, an enzyme involved in the biosynthesis of heparin. J Biol Chem. 1994 Apr 8;269(14):10438-43
    • Latest
      J:236935 Deligny A, et al., NDST2 (N-Deacetylase/N-Sulfotransferase-2) Enzyme Regulates Heparan Sulfate Chain Length. J Biol Chem. 2016 Sep 2;291(36):18600-7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory