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Mmp11
Gene Detail
 Symbol
Name
ID
Mmp11
matrix metallopeptidase 11
MGI:97008
Synonyms ST3, Stmy3, stromelysin 3
Feature Type protein coding gene
Genetic Map
Chromosome 10
38.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr10:75923222-75932502 bp, - strand
From VEGA annotation of GRCm38

  9281 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38116  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp11

Human
homologs
Human Homolog MMP11, matrix metallopeptidase 11 (stromelysin 3)
NCBI Gene ID 4320
neXtProt AC  NX_P24347
Human Synonyms  SL-3, ST3, STMY3
Human Chr (Location)  22q11.23; chr22:23772849-23784316 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit a decreased incidence of DMBA-induced carcinomas.
 
Interactions
Mmp11 interacts with 120 markers (Mir22, Mir23a, Mir30c-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process basement membrane organization, collagen catabolic process, ...
Component extracellular matrix, extracellular region, ...
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (124)    Tissues (62)    Images (45)
Theiler Stages: 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 100
Northern blot 11
RT-PCR 13
cDNA source data(38)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) Genomic(7) cDNA(38) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000031859 (Evidence)
Ensembl Gene ModelENSMUSG00000000901 (Evidence)
Entrez Gene17385 (Evidence)
UniGene4561
DFCITC1580793
DoTSDT.492013, DT.94296319
NIA Mouse Gene IndexU031937
EC3.4.24.-
PDB1HV5
Consensus CDS ProjectCCDS23937.1
International Mouse Knockout Project StatusMmp11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031859 VEGA Gene Model | MGI Sequence Detail 9281 C57BL/6J ±  kb
transcript OTTMUST00000078994 VEGA | MGI Sequence Detail 2288 Not Applicable 
polypeptide OTTMUSP00000042090 VEGA | MGI Sequence Detail 492 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(1 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR016293 Peptidase M10A, metazoans
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
Protein Ontology PR:000010471 stromelysin-3
References (Earliest) J:3364 Lefebvre O, et al., The breast cancer-associated stromelysin-3 gene is expressed during mouse mammary gland apoptosis. J Cell Biol. 1992 Nov;119(4):997-1002
(Latest) J:181974 Seo S, et al., Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2015-20
All references(66)
Other
accession IDs
MGD-MRK-12278, MGD-MRK-14628

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory