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Mmp10 Gene Detail
Summary
  • Symbol
    Mmp10
  • Name
    matrix metallopeptidase 10
  • Synonyms
    stromelysin 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97007
    NCBI Gene: 17384
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:7502353-7510241 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97007
protein coding gene Chr9:7502343-7510243 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034323
protein coding gene Chr9:4364790-4374650 (+)
A/J MGP_AJ_G0034301
protein coding gene Chr9:4468314-4476562 (+)
AKR/J MGP_AKRJ_G0034229
protein coding gene Chr9:4327850-4340713 (+)
BALB/cJ MGP_BALBcJ_G0034295
protein coding gene Chr9:4202764-4211100 (+)
C3H/HeJ MGP_C3HHeJ_G0034006
protein coding gene Chr9:4538450-4546011 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034817
protein coding gene Chr9:4529821-4538932 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031755
protein coding gene Chr9:3745285-3752652 (+)
CAST/EiJ MGP_CASTEiJ_G0033334
protein coding gene Chr9:4533120-4544452 (+)
CBA/J MGP_CBAJ_G0033979
protein coding gene Chr9:4630332-4637909 (+)
DBA/2J MGP_DBA2J_G0034136
protein coding gene Chr9:4350102-4357703 (+)
FVB/NJ MGP_FVBNJ_G0034081
protein coding gene Chr9:4122596-4136315 (+)
LP/J MGP_LPJ_G0034222
protein coding gene Chr9:4416441-4426275 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034125
protein coding gene Chr9:5371790-5379499 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034836
protein coding gene Chr9:4330399-4339160 (+)
PWK/PhJ MGP_PWKPhJ_G0033037
protein coding gene Chr9:4470086-4478495 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032875
protein coding gene Chr9:4571470-4580539 (+)
WSB/EiJ MGP_WSBEiJ_G0033449
protein coding gene Chr9:4347777-4360286 (+)



Homology
more
  • Human Ortholog
    MMP10, matrix metallopeptidase 10
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MMP10, matrix metallopeptidase 10
  • Synonyms
    SL-2, STMY2
  • Links
    NCBI Gene ID: 4319
    neXtProt AC: NX_P09238
    UniProt: P09238

  • Chr Location
    11q22.2; chr11:102770502-102780628 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047562 Ensembl Gene Model | MGI Sequence Detail 7889 C57BL/6J ±  kb
    transcript ENSMUST00000034488 Ensembl | MGI Sequence Detail 1722 Not Applicable  
    polypeptide ENSMUSP00000034488 Ensembl | MGI Sequence Detail 476 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 3
      cDNA 5
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12277, MGI:2143274
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 9
      Gene Ontology 4
      Phenotypes 20
    • Earliest
      J:17538 Gack S, et al., Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein. J Biol Chem. 1994 Apr 8;269(14):10363-9
    • Latest
      J:340401 Varadinkova S, et al., Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor. Front Cell Dev Biol. 2023;11:1168866

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory