Mmp10
Gene Detail

Symbol Name ID

Mmp10 matrix metallopeptidase 10 MGI:97007

Synonyms

stromelysin 2

Feature Type

protein coding gene

Genetic Map

Chromosome 9

2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:7502360-7510240 bp, + strand From NCBI annotation of GRCm38   7881 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; chimpanzee    (Mammalian Orthology)
Comparative Map (Mouse/Human Mmp10 ± 2 cM)

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp10

Human ortholog

MMP10 matrix metallopeptidase 10 (stromelysin 2) NCBI Gene ID 4319
Human Synonyms: SL-2, STMY2
Human Chr11:102641233-102651359 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	collagen catabolic process, proteolysis, ...
Component	extracellular matrix, extracellular region, ...
Function	calcium ion binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (12)    Tissues (6)   
Theiler Stages: 20, 23, 25, 28

Assay Type	Results
Western blot	4
RT-PCR	8

cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) Genomic(3) cDNA(4) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000047562 (Evidence)
Entrez Gene	17384 (Evidence)
UniGene	14126
DFCI	TC1589009
DoTS	DT.55129545
EC	3.4.24.22
Consensus CDS Project	CCDS22807.1
International Mouse Knockout Project Status	Mmp10

Sequences

Length	Strain/Species
genomic	17384	NCBI Gene Model | MGI Sequence Detail	7881	C57BL/6J
transcript	NM_019471	RefSeq | MGI Sequence Detail	1721	C57BL/6
polypeptide	O55123	UniProt | EBI | MGI Sequence Detail	476	Not Applicable

All sequences(17) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(68 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000585	Hemopexin/matrixin
InterPro	IPR018486	Hemopexin/matrixin, conserved site
InterPro	IPR018487	Hemopexin/matrixin, repeat
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR021158	Peptidase M10A, cysteine switch, zinc binding site
InterPro	IPR021190	Peptidase M10A, matrix metallopeptidase
InterPro	IPR016293	Peptidase M10A, matrix metallopeptidase, stromelysin type
InterPro	IPR001818	Peptidase M10, metallopeptidase
InterPro	IPR006026	Peptidase, metallopeptidase
InterPro	IPR002477	Peptidoglycan binding-like
Protein Ontology	PR:000010470	stromelysin-2

Graphical View of Protein Domain Structure

References

(Earliest) J:17538 Gack S, et al., Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein. J Biol Chem. 1994 Apr 8;269(14):10363-9
(Latest) J:190379 Koller FL, et al., Lack of MMP10 exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia. Lab Invest. 2012 Dec;92(12):1749-59
All references(45)

Other accession IDs

MGD-MRK-12277, MGI:2143274