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Mmp10
Gene Detail
Symbol

Name
ID
Mmp10
matrix metallopeptidase 10
MGI:97007
Synonyms
stromelysin 2
Feature Type
protein coding gene
Genetic Map
Chromosome 9
2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:7502352-7510238 bp, + strand
From Ensembl annotation of GRCm38

  7887 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20546  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken

HCOP human homology predictions: MMP10
Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp10

Human
homologs
MMP10, matrix metallopeptidase 10
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4319
neXtProt AC: NX_P09238

Human Synonyms: SL-2, STMY2

Human Chr (Location): 11q22.3; chr11:102770502-102780628 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection.
 
Interactions
Mmp10 interacts with 73 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process collagen catabolic process, proteolysis, ...
Component extracellular matrix, extracellular region, ...
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (12)    Tissues (7)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 4
RT-PCR 8
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) Genomic(3) cDNA(4) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000047562 (Evidence)
Entrez Gene 17384 (Evidence)
UniGene 14126
DFCI TC1589009
DoTS DT.55129545
EC 3.4.24.22
Consensus CDS Project CCDS22807.1
International Mouse Phenotyping Consortium Status Mmp10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047562 Ensembl Gene Model | MGI Sequence Detail 7887 C57BL/6J ±  kb
transcript ENSMUST00000034488 Ensembl | MGI Sequence Detail 1720 Not Applicable 
polypeptide ENSMUSP00000034488 Ensembl | MGI Sequence Detail 476 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(75 from dbSNP Build 137)    SNPs within 2kb including multiple locations(77)
Protein-related
information
ResourceIDDescription
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR021158 Peptidase M10A, cysteine switch, zinc binding site
InterPro IPR016293 Peptidase M10A, stromelysin-type
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010470 stromelysin-2
References
(Earliest) J:17538 Gack S, et al., Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein. J Biol Chem. 1994 Apr 8;269(14):10363-9
(Latest) J:219644 Gomez-Rodriguez V, et al., Functional MMP-10 is required for efficient tissue repair after experimental hind limb ischemia. FASEB J. 2015 Mar;29(3):960-72
All references(49)
Other
accession IDs
MGD-MRK-12277, MGI:2143274

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory