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Mmp10
Gene Detail
 Symbol
Name
ID
Mmp10
matrix metallopeptidase 10
MGI:97007
Synonyms stromelysin 2
Feature Type protein coding gene
Genetic Map
Chromosome 9
2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:7502360-7510240 bp, + strand
From NCBI annotation of GRCm38

  7881 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20546  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp10

Human
homologs
Human Homolog MMP10, matrix metallopeptidase 10 (stromelysin 2)
NCBI Gene ID 4319
neXtProt AC  NX_P09238
Human Synonyms  SL-2, STMY2
Human Chr (Location)  11q22.3; chr11:102770502-102780628 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection.
 
Interactions
Mmp10 interacts with 73 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process collagen catabolic process, proteolysis, ...
Component extracellular matrix, extracellular region, ...
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (12)    Tissues (7)   
Theiler Stages: 20, 23, 25, 27, 28
Assay TypeResults
Western blot 4
RT-PCR 8
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) Genomic(3) cDNA(4) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000047562 (Evidence)
Entrez Gene17384 (Evidence)
UniGene14126
DFCITC1589009
DoTSDT.55129545
EC3.4.24.22
Consensus CDS ProjectCCDS22807.1
International Mouse Knockout Project StatusMmp10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17384 NCBI Gene Model | MGI Sequence Detail 7881 C57BL/6J ±  kb
transcript NM_019471 RefSeq | MGI Sequence Detail 1734 C57BL/6 
polypeptide O55123 UniProt | EBI | MGI Sequence Detail 476 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(75 from dbSNP Build 137)    SNPs within 2kb including multiple locations(77)
Protein-related
information
ResourceIDDescription
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR021158 Peptidase M10A, cysteine switch, zinc binding site
InterPro IPR016293 Peptidase M10A, metazoans
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010470 stromelysin-2
Graphical View of Protein Domain Structure
References (Earliest) J:17538 Gack S, et al., Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein. J Biol Chem. 1994 Apr 8;269(14):10363-9
(Latest) J:206761 Bobadilla M, et al., MMP-10 is required for efficient muscle regeneration in mouse models of injury and muscular dystrophy. Stem Cells. 2014 Feb;32(2):447-61
All references(48)
Other
accession IDs
MGD-MRK-12277, MGI:2143274

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory