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Mme Gene Detail
Summary
  • Symbol
    Mme
  • Name
    membrane metallo endopeptidase
  • Synonyms
    6030454K05Rik, CD10, NEP, neprilysin, neutral endopeptidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:97004
    NCBI Gene: 17380
  • Gene Overview
    MyGene.info: MME
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:63295224-63383713 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 29.97 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    498 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97004
protein coding gene Chr3:63241537-63386030 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027261
protein coding gene Chr3:62275909-62427079 (+)
A/J MGP_AJ_G0027221
protein coding gene Chr3:60411788-60555465 (+)
AKR/J MGP_AKRJ_G0027191
protein coding gene Chr3:61589210-61743758 (+)
BALB/cJ MGP_BALBcJ_G0027234
protein coding gene Chr3:60169534-60316489 (+)
C3H/HeJ MGP_C3HHeJ_G0026977
protein coding gene Chr3:61807164-61962796 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027680
protein coding gene Chr3:64555246-64708506 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025034
protein coding gene Chr3:56874331-57018067 (+)
CAST/EiJ MGP_CASTEiJ_G0026429
protein coding gene Chr3:61974528-62126173 (+)
CBA/J MGP_CBAJ_G0026953
protein coding gene Chr3:66638267-66787760 (+)
DBA/2J MGP_DBA2J_G0027087
protein coding gene Chr3:59822450-59963422 (+)
FVB/NJ MGP_FVBNJ_G0027055
protein coding gene Chr3:58638947-58777599 (+)
LP/J MGP_LPJ_G0027198
protein coding gene Chr3:63103362-63259083 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027072
protein coding gene Chr3:71121382-71288852 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027738
protein coding gene Chr3:61526887-61674105 (+)
PWK/PhJ MGP_PWKPhJ_G0026161
protein coding gene Chr3:59411266-59555956 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025974
protein coding gene Chr3:61024759-61179022 (+)
WSB/EiJ MGP_WSBEiJ_G0026503
protein coding gene Chr3:61656400-61810630 (+)



Homology
more
  • Human Ortholog
    MME, membrane metalloendopeptidase
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MME, membrane metalloendopeptidase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CALLA, CD10, CMT2T, NEP, SCA43, SFE
  • Links
    NCBI Gene ID: 4311
    neXtProt AC: NX_P08473
    UniProt: P08473

  • Chr Location
    3q25.2; chr3:155024124-155183729 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Mme mouse models; 1 with human MME associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit enhanced allergic contact dermatitis responses, diffuse hepatic necrosis after LPS shock or treatment with a combination of TNF and interleukin-1 beta, and increased brain and plasma amyloid beta peptide levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17380 NCBI Gene Model | MGI Sequence Detail 88490 C57BL/6J ±  kb
    transcript NM_001289462 RefSeq | MGI Sequence Detail 6088 C57BL/6  
    polypeptide Q61391 UniProt | EBI | MGI Sequence Detail 750 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      Genomic 1
      cDNA 65
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12274, MGI:1924432, MGI:2140089
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 11
      Diseases 2
      Gene Ontology 6
      Phenotypes 35
    • Earliest
      J:761 Chen CY, et al., Murine common acute lymphoblastic leukemia antigen (CD10 neutral endopeptidase 24.11). Molecular characterization, chromosomal localization, and modeling of the active site. J Immunol. 1992 May 1;148(9):2817-25
    • Latest
      J:249550 Brar GS, et al., Neprilysin Is Required for Angiotensin-(1-7)'s Ability to Enhance Insulin Secretion via Its Proteolytic Activity to Generate Angiotensin-(1-2). Diabetes. 2017 Aug;66(8):2201-2212

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory