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Mme
Gene Detail
Symbol

Name
ID
Mme
membrane metallo endopeptidase
MGI:97004
Synonyms
6030454K05Rik, CD10, NEP, neprilysin, neutral endopeptidase
Feature Type
protein coding gene
Genetic Map
Chromosome 3
29.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr3:63295872-63382231 bp, + strand
From Ensembl annotation of GRCm38

  86360 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5275  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: neprilysin-like metallopeptidase
Gene Tree: Mme

Human
homologs
Human Homolog MME, membrane metallo-endopeptidase
NCBI Gene ID 4311
neXtProt AC  NX_P08473
Human Synonyms  CALLA, CD10, NEP, SFE
Human Chr (Location)  3q25.2; chr3:155079647-155183729 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(17) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit enhanced allergic contact dermatitis responses, diffuse hepatic necrosis after LPS shock or treatment with a combination of TNF and interleukin-1 beta, and increased brain and plasma amyloid beta peptide levels.
 
Human Diseases Modeled Using Mouse Mme (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Mme interacts with 312 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process beta-amyloid metabolic process, cellular response to cytokine stimulus, ...
Component axon, brush border, ...
Function endopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (94)    Tissues (47)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
RT-PCR 92
cDNA source data(63)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(67) Genomic(1) cDNA(64) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000027820 (Evidence)
Entrez Gene17380 (Evidence)
UniGene296022
DFCITC1580070, TC1624363, TC1673700, TC1737876
DoTSDT.101182829, DT.101218897, DT.101369009, DT.111060581, DT.486192
NIA Mouse Gene IndexU003285
EC3.4.24.11
PDB2YVC
Consensus CDS ProjectCCDS17381.1
International Mouse Knockout Project StatusMme
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027820 Ensembl Gene Model | MGI Sequence Detail 86360 C57BL/6J ±  kb
transcript ENSMUST00000029400 Ensembl | MGI Sequence Detail 4240 Not Applicable 
polypeptide ENSMUSP00000029400 Ensembl | MGI Sequence Detail 750 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(12) UniProt(3)
Polymorphisms
RFLP(4) : SNPs within 2kb(465 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR000718 Peptidase M13
InterPro IPR018497 Peptidase M13, C-terminal domain
InterPro IPR008753 Peptidase M13, N-terminal domain
Protein Ontology PR:000001898 neprilysin
References
(Earliest) J:761 Chen CY, et al., Murine common acute lymphoblastic leukemia antigen (CD10 neutral endopeptidase 24.11). Molecular characterization, chromosomal localization, and modeling of the active site. J Immunol. 1992 May 1;148(9):2817-25
(Latest) J:208576 Zraika S, et al., Neprilysin deficiency protects against fat-induced insulin secretory dysfunction by maintaining calcium influx. Diabetes. 2013 May;62(5):1593-601
All references(77)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12274, MGI:1924432, MGI:2140089

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory