Mme
Gene Detail

Symbol Name ID

Mme membrane metallo endopeptidase MGI:97004

Synonyms

6030454K05Rik, CD10, NEP, neprilysin, neutral endopeptidase

Feature Type

protein coding gene

Genetic Map

Chromosome 3

29.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr3:63295872-63382231 bp, + strand From NCBI annotation of GRCm38   86360 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Mme ± 2 cM)

Protein SuperFamily: neprilysin-like metallopeptidase
Gene Tree: Mme

Human ortholog

MME membrane metallo-endopeptidase NCBI Gene ID 4311
Human Synonyms: CALLA, CD10, NEP, SFE
Human Chr3:154797436-154901518 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(18) : Targeted(1) Gene trapped(17)
 

Mice homozygous for a knock-out allele exhibit enhanced allergic contact dermatitis responses, diffuse hepatic necrosis after LPS shock or treatment with a combination of TNF and interleukin-1 beta, and increased brain and plasma amyloid beta peptide levels.

 
Human Diseases Modeled Using Mouse Mme (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	beta-amyloid metabolic process, cellular response to cytokine stimulus, ...
Component	axon, brush border, ...
Function	endopeptidase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (94)    Tissues (47)    Images (4)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	2
RT-PCR	92

cDNA source data(66)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(70) Genomic(1) cDNA(67) Primer pair(1) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000027820 (Evidence)
Entrez Gene	17380 (Evidence)
UniGene	296022
DFCI	TC1580070, TC1624363, TC1737876
DoTS	DT.101218897, DT.101369009, DT.111060581, DT.486192
NIA Mouse Gene Index	U003285
EC	3.4.24.11
PDB	2YVC
Consensus CDS Project	CCDS17381.1
International Mouse Knockout Project Status	Mme

Sequences

Length	Strain/Species
genomic	17380	NCBI Gene Model | MGI Sequence Detail	86360	C57BL/6J
transcript	NM_008604	RefSeq | MGI Sequence Detail	4240	C57BL/6
polypeptide	Q61391	UniProt | EBI | MGI Sequence Detail	750	Not Applicable

All sequences(29) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(4) : SNPs(389 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR008753	Peptidase M13
InterPro	IPR000718	Peptidase M13, neprilysin
InterPro	IPR018497	Peptidase M13, neprilysin, C-terminal
Protein Ontology	PR:000001898	neprilysin

Graphical View of Protein Domain Structure

References

(Earliest) J:761 Chen CY, et al., Murine common acute lymphoblastic leukemia antigen (CD10 neutral endopeptidase 24.11). Molecular characterization, chromosomal localization, and modeling of the active site. J Immunol. 1992 May 1;148(9):2817-25
(Latest) J:179603 Koh YH, et al., The role of neutral endopeptidase in caerulein-induced acute pancreatitis. J Immunol. 2011 Nov 15;187(10):5429-39
All references(73)

Other accession IDs

MGD-MRK-12274, MGI:1924432, MGI:2140089