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Mme Gene Detail
Summary
  • Symbol
    Mme
  • Name
    membrane metallo endopeptidase
  • Synonyms
    6030454K05Rik, CD10, NEP, neprilysin, neutral endopeptidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:97004
    NCBI Gene: 17380
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:63202632-63291134 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 29.97 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    475 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97004
 protein coding gene Chr3:63148958-63293451 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027261
 protein coding gene Chr3:62275909-62427079 (+)
A/J MGP_AJ_G0027221
 protein coding gene Chr3:60411788-60555465 (+)
AKR/J MGP_AKRJ_G0027191
 protein coding gene Chr3:61589210-61743758 (+)
BALB/cJ MGP_BALBcJ_G0027234
 protein coding gene Chr3:60169534-60316489 (+)
C3H/HeJ MGP_C3HHeJ_G0026977
 protein coding gene Chr3:61807164-61962796 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027680
 protein coding gene Chr3:64555246-64708506 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025034
 protein coding gene Chr3:56874331-57018067 (+)
CAST/EiJ MGP_CASTEiJ_G0026429
 protein coding gene Chr3:61974528-62126173 (+)
CBA/J MGP_CBAJ_G0026953
 protein coding gene Chr3:66638267-66787760 (+)
DBA/2J MGP_DBA2J_G0027087
 protein coding gene Chr3:59822450-59963422 (+)
FVB/NJ MGP_FVBNJ_G0027055
 protein coding gene Chr3:58638947-58777599 (+)
LP/J MGP_LPJ_G0027198
 protein coding gene Chr3:63103362-63259083 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027072
 protein coding gene Chr3:71121382-71288852 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027738
 protein coding gene Chr3:61526887-61674105 (+)
PWK/PhJ MGP_PWKPhJ_G0026161
 protein coding gene Chr3:59411266-59555956 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025974
 protein coding gene Chr3:61024759-61179022 (+)
WSB/EiJ MGP_WSBEiJ_G0026503
 protein coding gene Chr3:61656400-61810630 (+)



Homology
more
  • Human Ortholog
    MME, membrane metalloendopeptidase
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MME, membrane metalloendopeptidase
  • Synonyms
    CALLA, CD10, CMT2T, NEP, SCA43, SFE
  • Links
    NCBI Gene ID: 4311
    neXtProt AC: NX_P08473
    UniProt: P08473

  • Chr Location
    3q25.2; chr3:155024124-155183729 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mme mouse models; 5 with human MME associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit enhanced allergic contact dermatitis responses, diffuse hepatic necrosis after LPS shock or treatment with a combination of TNF and interleukin-1 beta, and increased brain and plasma amyloid beta peptide levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    82
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    825
  • Tissues
    59
  • cDNA Data
    64
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17380 NCBI Gene Model | MGI Sequence Detail 88503 C57BL/6J ±  kb
    transcript NM_001289462 RefSeq | MGI Sequence Detail 6088 ZRU/MplStud  
    polypeptide Q61391 UniProt | EBI | MGI Sequence Detail 750 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      Genomic 1
      cDNA 65
      Primer pair 4
      Other 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12274, MGI:1924432, MGI:2140089
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 19
      Diseases 2
      Gene Ontology 9
      Phenotypes 46
    • Earliest
      J:761 Chen CY, et al., Murine common acute lymphoblastic leukemia antigen (CD10 neutral endopeptidase 24.11). Molecular characterization, chromosomal localization, and modeling of the active site. J Immunol. 1992 May 1;148(9):2817-25
    • Latest
      J:332093 Szeto IYY, et al., SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2122121119
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory