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Mme
Gene Detail
Symbol

Name
ID
Mme
membrane metallo endopeptidase
MGI:97004
Synonyms
6030454K05Rik, CD10, NEP, neprilysin, neutral endopeptidase
Feature Type
protein coding gene
Genetic Map
Chromosome 3
29.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr3:63290004-63383713 bp, + strand
From NCBI annotation of GRCm38

  93710 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5275  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: neprilysin-like metallopeptidase
Gene Tree: Mme

Human
homologs
Human Homolog MME, membrane metallo-endopeptidase
NCBI Gene ID 4311
neXtProt AC  NX_P08473
Human Synonyms  CALLA, CD10, NEP, SFE
Human Chr (Location)  3q25.2; chr3:155079647-155183729 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(19) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit enhanced allergic contact dermatitis responses, diffuse hepatic necrosis after LPS shock or treatment with a combination of TNF and interleukin-1 beta, and increased brain and plasma amyloid beta peptide levels.
 
Human Diseases Modeled Using Mouse Mme (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Mme interacts with 312 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process beta-amyloid metabolic process, cellular response to cytokine stimulus, ...
Component axon, brush border, ...
Function endopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (94)    Tissues (47)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
RT-PCR 92
cDNA source data(63)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(67) Genomic(1) cDNA(64) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000027820 (Evidence)
Entrez Gene17380 (Evidence)
UniGene296022
DFCITC1580070, TC1624363, TC1673700, TC1737876
DoTSDT.101182829, DT.101218897, DT.101369009, DT.111060581, DT.486192
NIA Mouse Gene IndexU003285
EC3.4.24.11
PDB2YVC
Consensus CDS ProjectCCDS17381.1
International Mouse Knockout Project StatusMme
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17380 NCBI Gene Model | MGI Sequence Detail 93710 C57BL/6J ±  kb
transcript NM_001289462 RefSeq | MGI Sequence Detail 6088 C57BL/6 
polypeptide Q61391 UniProt | EBI | MGI Sequence Detail 750 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(12) UniProt(3)
Polymorphisms
RFLP(4) : SNPs within 2kb(502 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR000718 Peptidase M13
InterPro IPR018497 Peptidase M13, C-terminal domain
InterPro IPR008753 Peptidase M13, N-terminal domain
Protein Ontology PR:000001898 neprilysin
Graphical View of Protein Domain Structure
References
(Earliest) J:761 Chen CY, et al., Murine common acute lymphoblastic leukemia antigen (CD10 neutral endopeptidase 24.11). Molecular characterization, chromosomal localization, and modeling of the active site. J Immunol. 1992 May 1;148(9):2817-25
(Latest) J:214999 Pearton DJ, et al., Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 and 3 and inhibiting Hand1 expression. Dev Biol. 2014 Aug 15;392(2):344-57
All references(79)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12274, MGI:1924432, MGI:2140089

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory