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Mme
Gene Detail
Symbol

Name
ID
Mme
membrane metallo endopeptidase
MGI:97004
Synonyms
6030454K05Rik, CD10, NEP, neprilysin, neutral endopeptidase
Feature Type
protein coding gene
Genetic Map
Chromosome 3
29.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr3:63241537-63386030 bp, + strand
From VEGA annotation of GRCm38

  144494 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5275  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: MME
Protein SuperFamily: neprilysin-like metallopeptidase
Gene Tree: Mme

Human
homologs
MME, membrane metallo-endopeptidase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4311
neXtProt AC: NX_P08473

Human Synonyms: CALLA, CD10, NEP, SFE

Human Chr (Location): 3q25.2; chr3:155024124-155183729 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MME

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(20) Targeted(1) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit enhanced allergic contact dermatitis responses, diffuse hepatic necrosis after LPS shock or treatment with a combination of TNF and interleukin-1 beta, and increased brain and plasma amyloid beta peptide levels.
 
Human Diseases Modeled in Mice Using Mme (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Mme interacts with 312 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process beta-amyloid metabolic process, cellular response to cytokine stimulus, ...
Component axon, brush border, ...
Function endopeptidase activity, exopeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (94)    Tissues (47)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
RT-PCR 92
cDNA source data(63)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(67) Genomic(1) cDNA(64) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000051889 (Evidence)
Ensembl Gene Model ENSMUSG00000027820 (Evidence)
Entrez Gene 17380 (Evidence)
UniGene 296022
DFCI TC1580070, TC1624363, TC1673700, TC1737876
DoTS DT.101182829, DT.101218897, DT.101369009, DT.111060581, DT.486192
NIA Mouse Gene Index U003285
EC 3.4.24.11
PDB 2YVC
Consensus CDS Project CCDS17381.1
International Mouse Phenotyping Consortium Status Mme
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051889 VEGA Gene Model | MGI Sequence Detail 144494 C57BL/6J ±  kb
transcript OTTMUST00000130649 VEGA | MGI Sequence Detail 3345 Not Applicable 
polypeptide OTTMUSP00000069987 VEGA | MGI Sequence Detail 750 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(10) UniProt(6)
Polymorphisms
RFLP(4) : SNPs within 2kb(810 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR000718 Peptidase M13
InterPro IPR018497 Peptidase M13, C-terminal domain
InterPro IPR008753 Peptidase M13, N-terminal domain
Protein Ontology PR:000001898 neprilysin
References
(Earliest) J:761 Chen CY, et al., Murine common acute lymphoblastic leukemia antigen (CD10 neutral endopeptidase 24.11). Molecular characterization, chromosomal localization, and modeling of the active site. J Immunol. 1992 May 1;148(9):2817-25
(Latest) J:214999 Pearton DJ, et al., Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 and 3 and inhibiting Hand1 expression. Dev Biol. 2014 Aug 15;392(2):344-57
All references(79)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12274, MGI:1924432, MGI:2140089

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory