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Clec10a Gene Detail
Summary
  • Symbol
    Clec10a
  • Name
    C-type lectin domain family 10, member A
  • Synonyms
    CD301a, Mgl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96975
    NCBI Gene: 17312
  • Gene Overview
    MyGene.info: CLEC10A
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:70166623-70170836 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.99 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    15
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96975
protein coding gene Chr11:70156197-70170836 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018583
protein coding gene Chr11:70675868-70685635 (+)
A/J MGP_AJ_G0018551
protein coding gene Chr11:67992607-67998085 (+)
AKR/J MGP_AKRJ_G0018520
protein coding gene Chr11:70027151-70033138 (+)
BALB/cJ MGP_BALBcJ_G0018523
protein coding gene Chr11:68320165-68324516 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0018974
protein coding gene Chr11:72758124-72789445 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016619
protein coding gene Chr11:64915420-64921817 (+)
CAST/EiJ MGP_CASTEiJ_G0017891
protein coding gene Chr11:70283436-70315525 (+)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0018418
protein coding gene Chr11:67573403-67578621 (+)
FVB/NJ MGP_FVBNJ_G0018408
protein coding gene Chr11:67227544-67231925 (+)
LP/J MGP_LPJ_G0018488
protein coding gene Chr11:71249992-71253864 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0019016
protein coding gene Chr11:70296455-70300103 (+)
PWK/PhJ MGP_PWKPhJ_G0017665
protein coding gene Chr11:68202121-68231318 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017455
protein coding gene Chr11:70092599-70097035 (+)
WSB/EiJ MGP_WSBEiJ_G0017945
protein coding gene Chr11:69960071-69964610 (+)



Homology
more
  • Human Ortholog
    CLEC10A, C-type lectin domain containing 10A
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CLEC10A, C-type lectin domain containing 10A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD301, CLECSF13, CLECSF14, HML, HML2, MGL
  • Links
    NCBI Gene ID: 10462
    neXtProt AC: NX_Q8IUN9
    UniProt: Q8IUN9

  • Chr Location
    17p13.1; chr17:7074537-7080635 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit elevated red blood cell counts but appear to be otherwise normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17312 NCBI Gene Model | MGI Sequence Detail 4214 C57BL/6J ±  kb
    transcript NM_001204252 RefSeq | MGI Sequence Detail 1501 C57BL/6  
    polypeptide P49300 UniProt | EBI | MGI Sequence Detail 304 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 27
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12220
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 16
    • Earliest
      J:5439 Bannerman RM, et al., Hereditary disorders of the red cell in animals. Prog Hematol. 1973;8:131-79
    • Latest
      J:240771 Van den Bossche J, et al., Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages. Cell Rep. 2016 Oct 11;17(3):684-696

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory