Kitl
Gene Detail

Symbol Name ID

Kitl kit ligand MGI:96974

Synonyms

blz, Gb, grizzle-belly, Kitl, Mgf, SCF, SF, Sl, SLF, Steel, Steel factor, stem cell factor

Feature Type

protein coding gene

Genetic Map

Chromosome 10

51.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(52)

Sequence Map

Chr10:100015630-100100413 bp, + strand From VEGA annotation of GRCm38   84784 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:692  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: Kit ligand precursor/stem cell factor
Gene Tree: Kitl

Human homologs

Human Homolog		KITLG, KIT ligand
NCBI Gene ID		4254
neXtProt AC		NX_P21583
Human Synonyms		FPH2, Kitl, KL-1, MGF, SCF, SF, SHEP7
Human Chr (Location)		12q22; chr12:88492793-88580473 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human KITLG

Alleles and phenotypes

All alleles(73) : Chemically and radiation induced(8) Chemically induced (ENU)(15) Gene trapped(4) Radiation induced(14) Spontaneous(21) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 

Mutations in this gene affect migration of embryonic stem cells and cause similar phenotypes to mutations in its receptor gene (Kit). Mutants show mild to severe defects in pigmentation, hemopoiesis and reproduction.

 
Phenotype Images(8)

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	cell adhesion, ectopic germ cell programmed cell death, ...
Component	cytoplasm, cytoskeleton, ...
Function	cytokine activity, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (91 records)

Data Summary: Results (578)    Tissues (319)    Images (135)
Theiler Stages: 1, 2, 3, 4, 5, 11, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28

Assay Type	Results
Immunohistochemistry	30
RNA in situ	459
RT-PCR	89

cDNA source data(106)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(138) Genomic(12) cDNA(111) Primer pair(10) Other(5)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000020799 (Evidence)
Ensembl Gene Model	ENSMUSG00000019966 (Evidence)
Entrez Gene	17311 (Evidence)
UniGene	45124
DFCI	TC1574857, TC1669190, TC1687465
DoTS	DT.490380, DT.97378616
NIA Mouse Gene Index	U011959
PDB	2O26, 2O27
Consensus CDS Project	CCDS36046.1
International Mouse Knockout Project Status	Kitl

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020799	VEGA Gene Model | MGI Sequence Detail	84784	C57BL/6J
transcript	OTTMUST00000049195	VEGA | MGI Sequence Detail	5645	Not Applicable
polypeptide	OTTMUSP00000022753	VEGA | MGI Sequence Detail	273	Not Applicable

All sequences(55) RefSeq(6) UniProt(4)

Polymorphisms

RFLP(17) : SNPs within 2kb(1131 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1133)

Protein-related information

Resource	ID	Description
InterPro	IPR012351	Four-helical cytokine, core
InterPro	IPR009079	Four-helical cytokine-like, core
InterPro	IPR003452	Stem cell factor
Protein Ontology	PR:000009345	kit ligand

References

(Earliest) J:104625 Russell LB, et al., Steel (Sl) and Pearl (pe). Mouse News Lett. 1953;8:14
(Latest) J:202252 Jones RL, et al., KIT signaling regulates primordial follicle formation in the neonatal mouse ovary. Dev Biol. 2013 Oct 1;382(1):186-97
All references(449)

Other accession IDs

MGD-MRK-10006, MGD-MRK-12219, MGD-MRK-14435, MGD-MRK-2018, MGD-MRK-2093, MGI:5304521