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Kitl
Gene Detail
 Symbol
Name
ID
Kitl
kit ligand
MGI:96974
Synonyms blz, Gb, grizzle-belly, Kitl, Mgf, SCF, SF, Sl, SLF, Steel, Steel factor, stem cell factor
Feature Type protein coding gene
Genetic Map
Chromosome 10
51.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(52)
Sequence Map
Chr10:100015630-100100413 bp, + strand
From VEGA annotation of GRCm38

  84784 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:692  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: Kit ligand precursor/stem cell factor
Gene Tree: Kitl

Human
homologs
Human Homolog KITLG, KIT ligand
NCBI Gene ID 4254
neXtProt AC  NX_P21583
Human Synonyms  FPH2, Kitl, KL-1, MGF, SCF, SF, SHEP7
Human Chr (Location)  12q22; chr12:88492793-88580473 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human KITLG
Mutations,
alleles, and
phenotypes
All mutations/alleles(72) : Chemically and radiation induced(8) Chemically induced (ENU)(15) Gene trapped(4) Radiation induced(14) Spontaneous(21) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene affect migration of embryonic stem cells and cause similar phenotypes to mutations in its receptor gene (Kit). Mutants show mild to severe defects in pigmentation, hemopoiesis and reproduction.
 
Phenotype Images(8)
Interactions
Kitl interacts with 423 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process cell adhesion, ectopic germ cell programmed cell death, ...
Component cytoplasm, cytoskeleton, ...
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (91 records)
Data Summary: Results (573)    Tissues (316)    Images (135)
Theiler Stages: 1, 2, 3, 4, 5, 11, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 30
RNA in situ 459
RT-PCR 84
cDNA source data(106)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(138) Genomic(12) cDNA(111) Primer pair(10) Other(5)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000020799 (Evidence)
Ensembl Gene ModelENSMUSG00000019966 (Evidence)
Entrez Gene17311 (Evidence)
UniGene45124
DFCITC1574857, TC1669190, TC1687465
DoTSDT.490380, DT.97378616
NIA Mouse Gene IndexU011959
PDB2O26, 2O27
Consensus CDS ProjectCCDS36046.1
International Mouse Knockout Project StatusKitl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020799 VEGA Gene Model | MGI Sequence Detail 84784 C57BL/6J ±  kb
transcript OTTMUST00000049195 VEGA | MGI Sequence Detail 5645 Not Applicable 
polypeptide OTTMUSP00000022753 VEGA | MGI Sequence Detail 273 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(6) UniProt(4)
Polymorphisms RFLP(17) : SNPs within 2kb(1131 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1133)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR003452 Stem cell factor
Protein Ontology PR:000009345 kit ligand
References (Earliest) J:104625 Russell LB, et al., Steel (Sl) and Pearl (pe). Mouse News Lett. 1953;8:14
(Latest) J:202252 Jones RL, et al., KIT signaling regulates primordial follicle formation in the neonatal mouse ovary. Dev Biol. 2013 Oct 1;382(1):186-97
All references(449)
Other
accession IDs
MGD-MRK-10006, MGD-MRK-12219, MGD-MRK-14435, MGD-MRK-2018, MGD-MRK-2093, MGI:5304521

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory