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Kitl Gene Detail
Summary
  • Symbol
    Kitl
  • Name
    kit ligand
  • Synonyms
    blz, Gb, grizzle-belly, Kitlg, Mgf, SCF, SF, Sl, SLF, Steel, Steel factor, stem cell factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:96974
    NCBI Gene: 17311
  • Gene Overview
    MyGene.info: KITLG
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr10:100015630-100100413 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      84784 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 51.40 cM
  • Mapping Data
    52 experiments
Homology
more
  • Human Ortholog
    KITLG, KIT ligand
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KITLG, KIT ligand
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DCUA, DFNA69, FPH2, FPHH, Kitl, KL-1, MGF, SCF, SF, SHEP7, SLF
  • Links
    NCBI Gene ID: 4254
    neXtProt AC: NX_P21583
    UniProt: P21583

  • Chr Location
    12q21.32; chr12:88492793-88580473 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human KITLG associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    135 phenotypes from 59 alleles in 59 genetic backgrounds
    26 phenotypes from multigenic genotypes
    10 images
    213 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene affect migration of embryonic stem cells and cause similar phenotypes to mutations in its receptor gene (Kit). Mutants show mild to severe defects in pigmentation, hemopoiesis and reproduction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    40
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    640
  • Tissues
    358
  • cDNA Data
    109
  • Literature Summary
    101
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020799 VEGA Gene Model | MGI Sequence Detail 84784 C57BL/6J ±  kb
    transcript OTTMUST00000049195 VEGA | MGI Sequence Detail 5645 Not Applicable  
    polypeptide OTTMUSP00000022753 VEGA | MGI Sequence Detail 273 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1120 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 144
      Genomic 12
      cDNA 115
      Primer pair 12
      Other 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10006, MGD-MRK-12219, MGD-MRK-14435, MGD-MRK-2018, MGD-MRK-2093, MGI:5304521
    References
    more
    • Summaries
      All 529
      Developmental Gene Expression 101
      Diseases 1
      Gene Ontology 20
      Phenotypes 213
    • Earliest
      J:3399 Sarvella PA, et al., Steel, a new dominant gene in the house mouse. J Hered. 1956;47:123-128
    • Latest
      J:252191 Cimmino L, et al., Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression. Cell. 2017 Sep 07;170(6):1079-1095.e20
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory