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Mgat1
Gene Detail
Symbol

Name
ID
Mgat1
mannoside acetylglucosaminyltransferase 1
MGI:96973
Synonyms
Mgat-1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
29.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr11:49244246-49263030 bp, + strand
From VEGA annotation of GRCm38

  18785 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1804  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: MGAT1
Protein SuperFamily: alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Gene Tree: Mgat1

Human
homologs
MGAT1, mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4245
neXtProt AC: NX_P26572

Human Synonyms: GLCNAC-TI, GLCT1, GLYT1, GNT-1, GNT-I, MGAT

Human Chr (Location): 5q35; chr5:180790541-180815652 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(5) Targeted(6)
Incidental mutations (data from Mutagenetix )
 
Homozygotes for targeted null mutations develop a deficiency of complex N-glycans during embryogenesis, exhibit defects of neural tube formation, vascularization, and left-right body axis determination, and die by embryonic day 10.5.
 
Interactions
Mgat1 interacts with 124 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (118)    Tissues (98)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 98
RT-PCR 20
cDNA source data(131)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mgat1    NEW 
Molecular
reagents
All nucleic(140) Genomic(7) cDNA(132) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000005541 (Evidence)
Ensembl Gene Model ENSMUSG00000020346 (Evidence)
Entrez Gene 17308 (Evidence)
UniGene 196933
DFCI TC1572576, TC1659675
DoTS DT.101323686, DT.101386850, DT.534189, DT.94282279, DT.94282283, DT.97360446, DT.99863187
NIA Mouse Gene Index U012522
EC 2.4.1.101
Consensus CDS Project CCDS24602.1
International Mouse Phenotyping Consortium Status Mgat1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005541 VEGA Gene Model | MGI Sequence Detail 18785 C57BL/6J ±  kb
transcript OTTMUST00000012314 VEGA | MGI Sequence Detail 2976 Not Applicable 
polypeptide OTTMUSP00000005693 VEGA | MGI Sequence Detail 447 Not Applicable 

For the selected sequences
All sequences(88) RefSeq(18) UniProt(4)
Polymorphisms
RFLP(3) : SNPs within 2kb(72 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004139 Glycosyl transferase, family 13
Protein Ontology PR:000010378 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
References
(Earliest) J:90003 Lo CW, Localization of low abundance DNA sequences in tissue sections by in situ hybridization. J Cell Sci. 1986 Mar;81:143-62
(Latest) J:221373 Christensen AP, et al., Oocyte glycoproteins regulate the form and function of the follicle basal lamina and theca cells. Dev Biol. 2015 May 15;401(2):287-98
All references(63)
Other
accession IDs
MGD-MRK-12217, MGD-MRK-12218

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory