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Mgat1 Gene Detail
Summary
  • Symbol
    Mgat1
  • Name
    mannoside acetylglucosaminyltransferase 1
  • Synonyms
    Mgat-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96973
    NCBI Gene: 17308
  • Gene Overview
    MyGene.info: MGAT1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:49244191-49263027 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 29.27 cM
  • Mapping Data
    24 experiments
Strain
Comparison
more
  • SNPs within 2kb
    72 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96973
protein coding gene Chr11:49244191-49263030 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018223
protein coding gene Chr11:48309742-48329727 (+)
A/J MGP_AJ_G0018193
protein coding gene Chr11:46449902-46468811 (+)
AKR/J MGP_AKRJ_G0018160
protein coding gene Chr11:47901062-47919876 (+)
BALB/cJ MGP_BALBcJ_G0018162
protein coding gene Chr11:46707168-46725728 (+)
C3H/HeJ MGP_C3HHeJ_G0017976
protein coding gene Chr11:47931940-47950619 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018613
protein coding gene Chr11:49773806-49800228 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016267
protein coding gene Chr11:44154121-44172601 (+)
CAST/EiJ MGP_CASTEiJ_G0017539
protein coding gene Chr11:47987381-48006619 (+)
CBA/J MGP_CBAJ_G0017948
protein coding gene Chr11:52083897-52102620 (+)
DBA/2J MGP_DBA2J_G0018057
protein coding gene Chr11:46307251-46326032 (+)
FVB/NJ MGP_FVBNJ_G0018052
protein coding gene Chr11:45901340-45919929 (+)
LP/J MGP_LPJ_G0018131
protein coding gene Chr11:48632441-48651778 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018076
protein coding gene Chr11:53598555-53617382 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018656
protein coding gene Chr11:48029722-48048522 (+)
PWK/PhJ MGP_PWKPhJ_G0017318
protein coding gene Chr11:46637580-46656318 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017112
protein coding gene Chr11:47711966-47734337 (+)
WSB/EiJ MGP_WSBEiJ_G0017590
protein coding gene Chr11:47685987-47704969 (+)



Homology
more
  • Human Ortholog
    MGAT1, mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MGAT1, mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLCNAC-TI, GLCT1, GLYT1, GNT-1, GnTI, GNT-I, MGAT
  • Links
    NCBI Gene ID: 4245
    neXtProt AC: NX_P26572
    UniProt: P26572

  • Chr Location
    5q35.3; chr5:180790541-180815652 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 4 alleles in 5 genetic backgrounds
    23 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations develop a deficiency of complex N-glycans during embryogenesis, exhibit defects of neural tube formation, vascularization, and left-right body axis determination, and die by embryonic day 10.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17308 NCBI Gene Model | MGI Sequence Detail 18837 C57BL/6J ±  kb
    transcript NM_001110148 RefSeq | MGI Sequence Detail 3165 C57BL/6  
    polypeptide P27808 UniProt | EBI | MGI Sequence Detail 447 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 142
      Genomic 7
      cDNA 133
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12217, MGD-MRK-12218
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 28
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:260130 Biswas B, et al., MGAT1 and Complex N-Glycans Regulate ERK Signaling During Spermatogenesis. Sci Rep. 2018 Jan 31;8(1):2022

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    07/09/2019
    MGI 6.14
    The Jackson Laboratory