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Mgat1
Gene Detail
 Symbol
Name
ID
Mgat1
mannoside acetylglucosaminyltransferase 1
MGI:96973
Synonyms Mgat-1
Feature Type protein coding gene
Genetic Map
Chromosome 11
29.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr11:49244246-49263030 bp, + strand
From VEGA annotation of GRCm38

  18785 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1804  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Gene Tree: Mgat1

Human
homologs
Human Homolog MGAT1, mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
NCBI Gene ID 4245
neXtProt AC  NX_P26572
Human Synonyms  GLCNAC-TI, GLCT1, GLYT1, GNT-1, GNT-I, MGAT
Human Chr (Location)  5q35; chr5:180790541-180810505 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Targeted(5)
Incidental mutations (data from Mutagenetix )
 
Homozygotes for targeted null mutations develop a deficiency of complex N-glycans during embryogenesis, exhibit defects of neural tube formation, vascularization, and left-right body axis determination, and die by embryonic day 10.5.
 
Interactions
Mgat1 interacts with 124 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process in utero embryonic development, protein glycosylation, ...
Component extracellular vesicular exosome, Golgi apparatus, ...
Function acetylglucosaminyltransferase activity, alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (118)    Tissues (97)    Images (2)
Theiler Stages: 4, 22, 28
Assay TypeResults
RNA in situ 98
RT-PCR 20
cDNA source data(131)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(140) Genomic(7) cDNA(132) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005541 (Evidence)
Ensembl Gene ModelENSMUSG00000020346 (Evidence)
Entrez Gene17308 (Evidence)
UniGene196933
DFCITC1572576, TC1659675
DoTSDT.101323686, DT.101386850, DT.534189, DT.94282279, DT.94282283, DT.97360446, DT.99863187
NIA Mouse Gene IndexU012522
EC2.4.1.101
Consensus CDS ProjectCCDS24602.1
International Mouse Knockout Project StatusMgat1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005541 VEGA Gene Model | MGI Sequence Detail 18785 C57BL/6J ±  kb
transcript OTTMUST00000012315 VEGA | MGI Sequence Detail 2729 Not Applicable 
polypeptide OTTMUSP00000005694 VEGA | MGI Sequence Detail 447 Not Applicable 

For the selected sequences
All sequences(88) RefSeq(18) UniProt(4)
Polymorphisms RFLP(3) : SNPs within 2kb(72 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004139 Glycosyl transferase, family 13
Protein Ontology PR:000010378 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
References (Earliest) J:90003 Lo CW, Localization of low abundance DNA sequences in tissue sections by in situ hybridization. J Cell Sci. 1986 Mar;81:143-62
(Latest) J:191575 Grasa P, et al., Embryos generated from oocytes lacking complex N- and O-glycans have compromised development and implantation. Reproduction. 2012 Oct;144(4):455-65
All references(61)
Other
accession IDs
MGD-MRK-12217, MGD-MRK-12218

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory