Mest
Gene Detail

Symbol Name ID

Mest mesoderm specific transcript MGI:96968

Synonyms

Peg1

Feature Type

protein coding gene

Genetic Map

Chromosome 6

12.53 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr6:30723547-30744394 bp, + strand From VEGA annotation of GRCm38   20848 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1800  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mest

Human homologs

Human Homolog		MEST, mesoderm specific transcript
NCBI Gene ID		4232
neXtProt AC		NX_Q5EB52
Human Synonyms		PEG1
Human Chr (Location)		7q32; chr7:130126016-130146138 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(1) Gene trapped(6)
 

Homozygotes for targeted null mutations exhibit retardation of embryonic growth and subtle cardiac abnormalities associated with reduced postnatal survival rates. Mutant females exhibit abnormal maternal behavior and impaired placentophagia.

 
Human Diseases Modeled Using Mouse Mest (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	regulation of lipid storage, response to retinoic acid
Component	endoplasmic reticulum, integral to membrane, ...
Function	catalytic activity, hydrolase activity

External Resources: FuncBase

Expression

Literature Summary: (51 records)
Data Summary: Results (163)    Tissues (72)    Images (32)
Theiler Stages: 4, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	62
Northern blot	17
RT-PCR	84

cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(47) Genomic(7) cDNA(28) Primer pair(10) Other(2)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000014405 (Evidence)
Ensembl Gene Model	ENSMUSG00000051855 (Evidence)
Entrez Gene	17294 (Evidence)
DFCI	TC1573769, TC1617732
NIA Mouse Gene Index	U021001
EC	3.-.-.-
Consensus CDS Project	CCDS19979.1
International Mouse Knockout Project Status	Mest

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014405	VEGA Gene Model | MGI Sequence Detail	20848	C57BL/6J
transcript	OTTMUST00000034122	VEGA | MGI Sequence Detail	937	Not Applicable
polypeptide	OTTMUSP00000015297	VEGA | MGI Sequence Detail	199	Not Applicable

All sequences(78) RefSeq(6) UniProt(8)

Polymorphisms

All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs(18 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000639	Epoxide hydrolase-like
Protein Ontology	PR:000010334	mesoderm-specific transcript protein

References

(Earliest) J:16422 Sado T, et al., A novel Mesoderm-Specific cDNA isolated from a mouse embryonal carcinoma cell line. Dev Growth Differ. 1993 Oct;35(5):551-60
(Latest) J:192829 Chandler RL, et al., ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF. Mol Cell Biol. 2013 Jan;33(2):265-80
All references(88)

Other accession IDs

MGD-MRK-12202, MGI:1353588, MGI:2141362