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Mest
Gene Detail
Symbol

Name
ID
Mest
mesoderm specific transcript
MGI:96968
Synonyms
Peg1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
12.53 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:30723547-30744394 bp, + strand
From VEGA annotation of GRCm38

  20848 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1800  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MEST
Gene Tree: Mest

Human
homologs
MEST, mesoderm specific transcript
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4232
neXtProt AC: NX_Q5EB52

Human Synonyms: PEG1

Human Chr (Location): 7q32; chr7:130486175-130506297 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(6) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit retardation of embryonic growth and subtle cardiac abnormalities associated with reduced postnatal survival rates. Mutant females exhibit abnormal maternal behavior and impaired placentophagia.
 
Human Diseases Modeled in Mice Using Mest (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Mest interacts with 228 markers (Mir10a, Mir15b, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process mesoderm development, metabolic process, ...
Component endoplasmic reticulum, extracellular exosome, ...
Function catalytic activity, coenzyme F390-A hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (56 records)
Data Summary: Results (163)    Tissues (74)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 62
Northern blot 17
RT-PCR 84
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mest ; ZFIN mest    NEW 
Molecular
reagents
All nucleic(47) Genomic(7) cDNA(28) Primer pair(10) Other(2)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000014405 (Evidence)
Ensembl Gene Model ENSMUSG00000051855 (Evidence)
Entrez Gene 17294 (Evidence)
NIA Mouse Gene Index U021001
EC 3.-.-.-
Consensus CDS Project CCDS19979.1
International Mouse Phenotyping Consortium Status Mest
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014405 VEGA Gene Model | MGI Sequence Detail 20848 C57BL/6J ±  kb
transcript OTTMUST00000034122 VEGA | MGI Sequence Detail 937 Not Applicable 
polypeptide OTTMUSP00000015297 VEGA | MGI Sequence Detail 199 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(6) UniProt(8)
Polymorphisms
All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(49 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000073 Alpha/beta hydrolase fold-1
InterPro IPR000639 Epoxide hydrolase-like
Protein Ontology PR:000010334 mesoderm-specific transcript protein
References
(Earliest) J:16422 Sado T, et al., A novel Mesoderm-Specific cDNA isolated from a mouse embryonal carcinoma cell line. Dev Growth Differ. 1993 Oct;35(5):551-60
(Latest) J:208342 Yang D, et al., miR-335 promotes mesendodermal lineage segregation and shapes a transcription factor gradient in the endoderm. Development. 2014 Feb;141(3):514-25
All references(94)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12202, MGI:1353588, MGI:2141362

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory