Mep1b MGI Mouse Gene Detail - MGI:96964

Symbol

Mep1b
Name

meprin 1 beta
Synonyms

Mep-1b, meprin beta

Feature Type

protein coding gene
IDs

MGI:96964
NCBI Gene: 17288
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr18:21205401-21233256 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 11.81 cM
Mapping Data

3 experiments

SNPs within 2kb

208 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96964	protein coding gene	Chr18:21194980-21233256 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024187	protein coding gene	Chr18:18698904-18726703 (+)
A/J	MGP_AJ_G0024151	protein coding gene	Chr18:18199882-18227919 (+)
AKR/J	MGP_AKRJ_G0024120	protein coding gene	Chr18:18763591-18791164 (+)
BALB/cJ	MGP_BALBcJ_G0024151	protein coding gene	Chr18:18260477-18288175 (+)
C3H/HeJ	MGP_C3HHeJ_G0023919	protein coding gene	Chr18:18704011-18733127 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024593	protein coding gene	Chr18:19589680-19617819 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022035	protein coding gene	Chr18:17318189-17346806 (+)
CAST/EiJ	MGP_CASTEiJ_G0023392	protein coding gene	Chr18:18482412-18513322 (+)
CBA/J	MGP_CBAJ_G0023887	protein coding gene	Chr18:20093758-20129319 (+)
DBA/2J	MGP_DBA2J_G0024019	protein coding gene	Chr18:17907646-17935991 (+)
FVB/NJ	MGP_FVBNJ_G0023985	protein coding gene	Chr18:17688270-17716416 (+)
LP/J	MGP_LPJ_G0024100	protein coding gene	Chr18:18858079-18885814 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024013	protein coding gene	Chr18:20975599-21007607 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024641	protein coding gene	Chr18:18533736-18563685 (+)
PWK/PhJ	MGP_PWKPhJ_G0023137	protein coding gene	Chr18:18014076-18042795 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022946	protein coding gene	Chr18:18721916-18754338 (+)
WSB/EiJ	MGP_WSBEiJ_G0023457	protein coding gene	Chr18:18451188-18480780 (+)

Human Ortholog

MEP1B, meprin A subunit beta

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MEP1B, meprin A subunit beta
Links

HGNC:7020

NCBI Gene ID: 4225

neXtProt AC: NX_Q16820

UniProt: Q16820
Chr Location

18q12.1; chr18:32185069-32220404 (+) GRCh38

MGI Vertebrate Homology

Mep1b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MEP1B
Protein SuperFamily

Meprin
Gene Tree

Mep1b

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Phenotype Summary

13 phenotypes from 2 alleles in 4 genetic backgrounds
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

4
Gene trapped

2
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit 50% prenatal lethality; survivors have reduced birth weight and show altered renal gene expression, but otherwise are apparently normal.

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All GO Annotations

11
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

744
Tissues

12
cDNA Data

41
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mep1b

ZFIN mep1ba

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All Sequences

36
RefSeq

2
UniProt

3
CCDS

CCDS37747.1

Ensembl

ENSMUSG00000024313 (Evidence)
NCBI Gene

17288

			Length	Strain/Species	Flank
genomic	17288	NCBI Gene Model \| MGI Sequence Detail	27856	C57BL/6J	± kb
transcript	NM_008586	RefSeq \| MGI Sequence Detail	2286	Not Specified
polypeptide	Q61847	UniProt \| EBI \| MGI Sequence Detail	704	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010325 meprin A subunit beta

(term hierarchy)
EC

3.4.24.63
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR000742 EGF-like domain

IPR000998 MAM domain

IPR002083 MATH/TRAF domain

IPR008294 Meprin alpha/beta subunit

IPR024079 Metallopeptidase, catalytic domain superfamily

IPR001506 Peptidase M12A

IPR006026 Peptidase, metallopeptidase

IPR049342 TRAF1-6/MEP1A/B-like, MATH domain

IPR008974 TRAF-like

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All nucleic 45

Genomic 1

cDNA 44

Microarray probesets 3

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MGD-MRK-12195, MGD-MRK-12198

Summaries

All 68

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 31
Earliest

J:17708 Gorbea CM, et al., Homo- and heterotetrameric forms of the membrane-bound metalloendopeptidases meprin A and B. Arch Biochem Biophys. 1991 Nov 1;290(2):549-53
Latest

J:334914 Bulck C, et al., Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis. Sci Adv. 2023 Mar 31;9(13):eadf4055

TSS for Mep1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150228	Chr18:21205386-21205408 (+)	-4 bp
Tssr150229	Chr18:21224220-21224246 (+)	18,832 bp
Tssr150230	Chr18:21226349-21226383 (+)	20,965 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23