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Mep1a Gene Detail
Summary
  • Symbol
    Mep1a
  • Name
    meprin 1 alpha
  • Synonyms
    Mep1, Mep-1, Mep-1a, meprin A alpha-subunit, meprin alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:96963
    NCBI Gene: 17287
  • Gene Overview
    MyGene.info: MEP1A
Location & Maps
more
  • Sequence Map
    Chr17:43474324-43502812 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28489 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 19.73 cM, cytoband C1-D1
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    MEP1A, meprin A subunit alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MEP1A, meprin A subunit alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PPHA
  • Links
    NCBI Gene ID: 4224
    neXtProt AC: NX_Q16819

  • Chr Location
    6p12-p11; chr6:46793357-46845987 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 31323
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: MEP1A
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased litter size, reduced LPS-induced renal injury and bladder inflammation, and increased susceptibility to sodium dextran sulfate-induced colitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029860 VEGA Gene Model | MGI Sequence Detail 28489 C57BL/6J ±  kb
transcript OTTMUST00000074103 VEGA | MGI Sequence Detail 2967 Not Applicable  
polypeptide OTTMUSP00000038454 VEGA | MGI Sequence Detail 747 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    256 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 170
    Genomic 6
    cDNA 164

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-12193, MGD-MRK-12194, MGD-MRK-12196, MGD-MRK-12197, MGI:2146793, MGI:2147044
References
more
  • Summaries
    All 55
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:7573 Bond JS, et al., Mep-1 gene controlling a kidney metalloendopeptidase is linked to the major histocompatibility complex in mice. Proc Natl Acad Sci U S A. 1984 Sep;81(17):5542-5
  • Latest
    J:213004 Keiffer TR, et al., Meprin metalloproteases inactivate interleukin 6. J Biol Chem. 2014 Mar 14;289(11):7580-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory