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Mep1a
Gene Detail
Symbol

Name
ID
Mep1a
meprin 1 alpha
MGI:96963
Synonyms
Mep1, Mep-1, Mep-1a, meprin A alpha-subunit, meprin alpha
Feature Type
protein coding gene
Genetic Map
Chromosome 17
19.73 cM, cytoband C1-D1
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr17:43474324-43502812 bp, - strand
From VEGA annotation of GRCm38

  28489 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31323  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MEP1A
Protein SuperFamily: meprin
Gene Tree: Mep1a

Human
homologs
MEP1A, meprin A, alpha (PABA peptide hydrolase)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4224
neXtProt AC: NX_Q16819

Human Synonyms: PPHA

Human Chr (Location): 6p12-p11; chr6:46793357-46845987 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased litter size, reduced LPS-induced renal injury and bladder inflammation, and increased susceptibility to sodium dextran sulfate-induced colitis.
 
Interactions
Mep1a interacts with 100 markers (Mir27b, Mir30c-1, Mir30c-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process proteolysis
Component extracellular exosome, integral component of membrane, ...
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (18)    Tissues (2)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 18
cDNA source data(162)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mep1a ; ZFIN mep1a.1, mep1a.2    NEW 
Molecular
reagents
All nucleic(168) Genomic(6) cDNA(162)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000029860 (Evidence)
Ensembl Gene Model ENSMUSG00000023914 (Evidence)
Entrez Gene 17287 (Evidence)
UniGene 5346
DFCI TC1574647, TC1659395
DoTS DT.101269909, DT.534199
NIA Mouse Gene Index U037821
EC 3.4.24.-, 3.4.24.18
PDB 1IAF
Consensus CDS Project CCDS37623.1
International Mouse Phenotyping Consortium Status Mep1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029860 VEGA Gene Model | MGI Sequence Detail 28489 C57BL/6J ±  kb
transcript OTTMUST00000074103 VEGA | MGI Sequence Detail 2967 Not Applicable 
polypeptide OTTMUSP00000038454 VEGA | MGI Sequence Detail 747 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(241 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR000998 MAM domain
InterPro IPR002083 MATH
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001506 Peptidase M12A, astacin
InterPro IPR008294 Peptidase M12A, meprin alpha subunit
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR008974 TRAF-like
Protein Ontology PR:000010324 meprin A subunit alpha
References
(Earliest) J:7573 Bond JS, et al., Mep-1 gene controlling a kidney metalloendopeptidase is linked to the major histocompatibility complex in mice. Proc Natl Acad Sci U S A. 1984 Sep;81(17):5542-5
(Latest) J:213004 Keiffer TR, et al., Meprin metalloproteases inactivate interleukin 6. J Biol Chem. 2014 Mar 14;289(11):7580-8
All references(59)
Other
accession IDs
MGD-MRK-12193, MGD-MRK-12194, MGD-MRK-12196, MGD-MRK-12197, MGI:2146793, MGI:2147044

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory