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Smcp Gene Detail
Summary
  • Symbol
    Smcp
  • Name
    sperm mitochondria-associated cysteine-rich protein
  • Synonyms
    Mcsp
  • Feature Type
    protein coding gene
  • IDs
    MGI:96945
    NCBI Gene: 17235
  • Gene Overview
    MyGene.info: SMCP
Location & Maps
more
  • Sequence Map
    Chr3:92583867-92588997 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5131 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.14 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SMCP, sperm mitochondria associated cysteine rich protein
  • Human Ortholog
    SMCP, sperm mitochondria associated cysteine rich protein
    Orthology source: HGNC
  • Synonyms
    HSMCSGEN1, MCS, MCSP
  • Links
    NCBI Gene ID: 4184
    neXtProt AC: NX_P49901

  • Chr Location
    1q21.3; chr1:152878322-152885047 (+)  GRCh38.p2

  • HCOP
    human homology predictions: SMCP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Smcp
  • Incidental Mutations
On a 129 inbred background, males homozygous for a targeted null mutation produce sperm with reduced motility and capacity to penetrate oocytes resulting in infertility. Noninbred mutant males are normally fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051844 VEGA Gene Model | MGI Sequence Detail 5131 C57BL/6J ±  kb
transcript OTTMUST00000130582 VEGA | MGI Sequence Detail 744 Not Applicable  
polypeptide OTTMUSP00000069960 VEGA | MGI Sequence Detail 143 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    11 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000015276 sperm mitochondrial-associated cysteine-rich protein
Molecular
Reagents
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  • All nucleic 84
    Genomic 1
    cDNA 82
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-12159
References
more
  • Summaries
    All 24
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:3281 Karimpour I, et al., Sequence of the gene encoding the mitochondrial capsule selenoprotein of mouse sperm: identification of three in-phase TGA selenocysteine codons. DNA Cell Biol. 1992 Nov;11(9):693-9
  • Latest
    J:221349 Vourekas A, et al., The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing. Genes Dev. 2015 Mar 15;29(6):617-29

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory