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Smcp Gene Detail
Summary
  • Symbol
    Smcp
  • Name
    sperm mitochondria-associated cysteine-rich protein
  • Synonyms
    Mcsp
  • Feature Type
    protein coding gene
  • IDs
    MGI:96945
    NCBI Gene: 17235
  • Gene Overview
    MyGene.info: SMCP
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:92583867-92588997 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5131 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.14 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SMCP, sperm mitochondria associated cysteine rich protein
  • Human Ortholog
    SMCP, sperm mitochondria associated cysteine rich protein
    Orthology source: HGNC
  • Synonyms
    HSMCSGEN1, MCS, MCSP
  • Links
    NCBI Gene ID: 4184
    neXtProt AC: NX_P49901
    UniProt: P49901

  • Chr Location
    1q21.3; chr1:152878322-152885047 (+)  GRCh38.p7

  • HCOP
    human homology predictions: SMCP
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
On a 129 inbred background, males homozygous for a targeted null mutation produce sperm with reduced motility and capacity to penetrate oocytes resulting in infertility. Noninbred mutant males are normally fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    • UniProt
    • UniGene
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000051844 VEGA Gene Model | MGI Sequence Detail 5131 C57BL/6J ±  kb
    transcript OTTMUST00000130582 VEGA | MGI Sequence Detail 744 Not Applicable  
    polypeptide OTTMUSP00000069960 VEGA | MGI Sequence Detail 143 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      11 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 84
      Genomic 1
      cDNA 82
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-12159
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:10296 Kleene KC, et al., Sequence and developmental expression of the mRNA encoding the seleno-protein of the sperm mitochondrial capsule in the mouse. Dev Biol. 1990 Feb;137(2):395-402
    • Latest
      J:221349 Vourekas A, et al., The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing. Genes Dev. 2015 Mar 15;29(6):617-29

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory