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Smcp
Gene Detail
Symbol

Name
ID
Smcp
sperm mitochondria-associated cysteine-rich protein
MGI:96945
Synonyms
Mcsp
Feature Type
protein coding gene
Genetic Map
Chromosome 3
40.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:92583867-92588997 bp, - strand
From VEGA annotation of GRCm38

  5131 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HCOP human homology predictions: SMCP
Gene Tree: Smcp
Human
homologs
SMCP, sperm mitochondria-associated cysteine-rich protein
Orthology source: HGNC

IDs:
NCBI Gene ID: 4184
neXtProt AC: NX_P49901

Human Synonyms: HSMCSGEN1, MCS, MCSP

Human Chr (Location): 1q21.3; chr1:152878322-152885047 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
On a 129 inbred background, males homozygous for a targeted null mutation produce sperm with reduced motility and capacity to penetrate oocytes resulting in infertility. Noninbred mutant males are normally fertile.
 
Interactions
Smcp interacts with 44 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process binding of sperm to zona pellucida, penetration of zona pellucida, ...
Component cytoplasm, membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (3)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 3
cDNA source data(82)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(84) Genomic(1) cDNA(82) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000051844 (Evidence)
Ensembl Gene Model ENSMUSG00000074435 (Evidence)
Entrez Gene 17235 (Evidence)
UniGene 331192
DFCI TC1579248
DoTS DT.99847155
International Mouse Phenotyping Consortium Status Smcp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051844 VEGA Gene Model | MGI Sequence Detail 5131 C57BL/6J ±  kb
transcript OTTMUST00000130582 VEGA | MGI Sequence Detail 744 Not Applicable 
polypeptide OTTMUSP00000069960 VEGA | MGI Sequence Detail 143 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000015276 sperm mitochondrial-associated cysteine-rich protein
References
(Earliest) J:3281 Karimpour I, et al., Sequence of the gene encoding the mitochondrial capsule selenoprotein of mouse sperm: identification of three in-phase TGA selenocysteine codons. DNA Cell Biol. 1992 Nov;11(9):693-9
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(25)
Other
accession IDs
MGD-MRK-12159

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory