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Tpsab1
Gene Detail
Symbol

Name
ID
Tpsab1
tryptase alpha/beta 1
MGI:96943
Synonyms
Mcp-7, Mcpt7, MMCP-7
Feature Type
protein coding gene
Genetic Map
Chromosome 17
12.53 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr17:25343245-25345562 bp, - strand
From VEGA annotation of GRCm38

  2318 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: trypsin
Gene Tree: Tpsab1
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Radiation induced(2) Spontaneous(1)
Genomic Mutations involving Tpsab1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
A spontaneous splice-site point mutation in this gene results in constitutive loss of its expression in synovial mast cells of C57BL/6 mice.
 
Interactions
Tpsab1 interacts with 29 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process proteolysis
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (151)    Tissues (82)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 19
Northern blot 15
RT-PCR 117
cDNA source data(8)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(5) cDNA(9) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033716 (Evidence)
Ensembl Gene ModelENSMUSG00000024173 (Evidence)
Entrez Gene100503895 (Evidence)
UniGene3301
DFCITC1591861, TC1614893
DoTSDT.40157997, DT.91354624, DT.91398684
NIA Mouse Gene IndexU037553
EC3.4.21.59
International Mouse Knockout Project StatusTpsab1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033716 VEGA Gene Model | MGI Sequence Detail 2318 C57BL/6J ±  kb
transcript OTTMUST00000084924 VEGA | MGI Sequence Detail 1156 Not Applicable 
polypeptide OTTMUSP00000045811 VEGA | MGI Sequence Detail 310 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(3) UniProt(7)
Polymorphisms
RFLP(2) : SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000016935 tryptase
References
(Earliest) J:10169 Serafin WE, et al., Identification and molecular cloning of a novel mouse mucosal mast cell serine protease. J Biol Chem. 1990 Jan 5;265(1):423-9
(Latest) J:197180 Buniello A, et al., Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness. PLoS One. 2013;8(2):e56274
All references(39)
Other
accession IDs
MGD-MRK-12149, MGD-MRK-12157

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory