Tpsab1
Gene Detail

Symbol Name ID

Tpsab1 tryptase alpha/beta 1 MGI:96943

Synonyms

Mcp-7, Mcpt7, MMCP-7

Feature Type

protein coding gene

Genetic Map

Chromosome 17

12.53 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr17:25343245-25345562 bp, - strand From VEGA annotation of GRCm38   2318 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

Protein SuperFamily: trypsin
Gene Tree: Tpsab1

Alleles and phenotypes

All alleles(1) : Spontaneous(1)
 

A spontaneous splice-site point mutation in this gene results in constitutive loss of its expression in synovial mast cells of C57BL/6 mice.

 

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	proteolysis
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (151)    Tissues (82)    Images (3)
Theiler Stages: 6, 7, 9, 10, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	19
Northern blot	15
RT-PCR	117

cDNA source data(8)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(18) Genomic(5) cDNA(9) Primer pair(4)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000033716 (Evidence)
Ensembl Gene Model	ENSMUSG00000024173 (Evidence)
Entrez Gene	100503895 (Evidence)
UniGene	3301
DFCI	TC1591861, TC1614893
DoTS	DT.40157997, DT.91354624, DT.91398684
NIA Mouse Gene Index	U037553
EC	3.4.21.59
International Mouse Knockout Project Status	Tpsab1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033716	VEGA Gene Model | MGI Sequence Detail	2318	C57BL/6J
transcript	OTTMUST00000084924	VEGA | MGI Sequence Detail	1156	Not Applicable
polypeptide	OTTMUSP00000045811	VEGA | MGI Sequence Detail	310	Not Applicable

All sequences(31) RefSeq(3) UniProt(5)

Polymorphisms

RFLP(2) : SNPs(0 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
Protein Ontology	PR:000016935	tryptase

References

(Earliest) J:10169 Serafin WE, et al., Identification and molecular cloning of a novel mouse mucosal mast cell serine protease. J Biol Chem. 1990 Jan 5;265(1):423-9
(Latest) J:169007 Hamilton MJ, et al., Essential role for mast cell tryptase in acute experimental colitis. Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):290-5
All references(38)

Other accession IDs

MGD-MRK-12149, MGD-MRK-12157