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Tpsb2
Gene Detail
Symbol

Name
ID
Tpsb2
tryptase beta 2
MGI:96942
STS
Synonyms
Mcp6, Mcp-6, Mcpt6, MMCP-6
Feature Type
protein coding gene
Genetic Map
Chromosome 17
12.53 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr17:25366550-25368094 bp, + strand
From Ensembl annotation of GRCm38

  1545 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55729  Vertebrate Homology Class
2 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog

Protein SuperFamily: trypsin
Gene Tree: Tpsb2

Human
homologs
Human Homolog TPSAB1, tryptase alpha/beta 1
NCBI Gene ID 7177
neXtProt AC  NX_P20231, NX_Q15661
Human Synonyms  TPS1, TPS2, TPSB1
Human Chr (Location)  16p13.3; chr16:1240677-1242554 (+)  GRCh38
Human Homolog TPSB2, tryptase beta 2 (gene/pseudogene)
NCBI Gene ID 64499
neXtProt AC  NX_P20231
Human Synonyms  TPS2, tryptaseB, tryptaseC
Human Chr (Location)  16p13.3; chr16:1228336-1230184 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Radiation induced(2) Targeted(2)
Genomic Mutations involving Tpsb2 (2)
 
Mice homozygous for a knock-out allele show reduced recruitment of eosinophils to sites of T. spiralis larvae and decreased elimination of larvae in chronically infected skeletal muscle. Mice homozygous for a knock-in allele show a reduced ability to clear K. pneumoniae from their peritoneal cavity.
 
Interactions
Tpsb2 interacts with 34 markers (Mir23a, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process inflammatory response, proteolysis
Component extracellular matrix, extracellular region, ...
Function catalytic activity, heparin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (85)    Tissues (52)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 45
Northern blot 15
RT-PCR 25
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(2) cDNA(23) Primer pair(4)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000033825 (Evidence)
Entrez Gene17229 (Evidence)
UniGene7409
DFCITC1585442
DoTSDT.50316059, DT.55161112, DT.55168992, DT.87057170
NIA Mouse Gene IndexU017673
EC3.4.21.59
Consensus CDS ProjectCCDS28517.1
International Mouse Knockout Project StatusTpsb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033825 Ensembl Gene Model | MGI Sequence Detail 1545 C57BL/6J ±  kb
transcript ENSMUST00000069616 Ensembl | MGI Sequence Detail 1081 Not Applicable 
polypeptide ENSMUSP00000063499 Ensembl | MGI Sequence Detail 276 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000016592 tryptase beta-2
References
(Earliest) J:11003 Reynolds DS, et al., Cloning of the cDNA and gene of mouse mast cell protease-6. Transcription by progenitor mast cells and mast cells of the connective tissue subclass. J Biol Chem. 1991 Feb 25;266(6):3847-53
(Latest) J:207182 Roy A, et al., Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation. J Biol Chem. 2014 Jan 3;289(1):237-50
All references(53)
Other
accession IDs
MGD-MRK-12148, MGD-MRK-12156, MGI:2147011

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory