About   Help   FAQ
Mcpt4
Gene Detail
Symbol

Name
ID
Mcpt4
mast cell protease 4
MGI:96940
Synonyms
Mcp4, Mcp-4, MMCP-4, MMCP-4A, MMCP-4B, myonase
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:56059744-56062310 bp, - strand
From NCBI annotation of GRCm38

  2567 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:130645  Vertebrate Homology Class
1 mouse; 1 rat; 1 dog

Protein SuperFamily: trypsin
Gene Tree: Mcpt4

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this locus affects thrombin regulation and fibronectin turnover.
 
Interactions
Mcpt4 interacts with 46 markers (Mir27a, Mir30a, Mir30d, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process protein processing, proteolysis, ...
Component extracellular space, intracellular
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (37)    Tissues (2)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 37
cDNA source data(26)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) Genomic(6) cDNA(26)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000061068 (Evidence)
Entrez Gene 17227 (Evidence)
UniGene 439684
DFCI TC1583116, TC1596388, TC1755942
DoTS DT.491615, DT.94326437
NIA Mouse Gene Index U319833
EC 3.4.21.-
Consensus CDS Project CCDS27140.1
International Mouse Phenotyping Consortium Status Mcpt4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17227 NCBI Gene Model | MGI Sequence Detail 2567 C57BL/6J ±  kb
transcript NM_010779 RefSeq | MGI Sequence Detail 990 C57BL/6 
polypeptide P21812 UniProt | EBI | MGI Sequence Detail 246 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(160 from dbSNP Build 137)    SNPs within 2kb including multiple locations(176)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000010904 mast cell protease 4
Graphical View of Protein Domain Structure
References
(Earliest) J:10169 Serafin WE, et al., Identification and molecular cloning of a novel mouse mucosal mast cell serine protease. J Biol Chem. 1990 Jan 5;265(1):423-9
(Latest) J:209921 Bankova LG, et al., Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions. J Immunol. 2014 Mar 15;192(6):2812-20
All references(57)
Other
accession IDs
MGD-MRK-12146, MGD-MRK-12154

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/30/2015
MGI 5.22
The Jackson Laboratory