About   Help   FAQ
Mcpt1 Gene Detail
Summary
  • Symbol
    Mcpt1
  • Name
    mast cell protease 1
  • Synonyms
    Mcp-1, vascular chymase
  • Feature Type
    protein coding gene
  • IDs
    MGI:96937
    NCBI Gene: 17224
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:56017971-56020384 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    100 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96937
protein coding gene Chr14:56017964-56020391 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021379
protein coding gene Chr14:50091450-50093877 (+)
A/J MGP_AJ_G0021338
protein coding gene Chr14:49085679-49088106 (+)
AKR/J MGP_AKRJ_G0021314
protein coding gene Chr14:50855855-50858282 (+)
BALB/cJ MGP_BALBcJ_G0021342
protein coding gene Chr14:49055997-49058424 (+)
C3H/HeJ MGP_C3HHeJ_G0021122
protein coding gene Chr14:50535625-50538052 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021780
protein coding gene Chr14:52598797-52601224 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0020641
protein coding gene Chr14:46816683-46819110 (+)
CBA/J MGP_CBAJ_G0021089
protein coding gene Chr14:54164417-54166844 (+)
DBA/2J MGP_DBA2J_G0021210
protein coding gene Chr14:48809112-48811536 (+)
FVB/NJ MGP_FVBNJ_G0021192
protein coding gene Chr14:48240419-48242846 (+)
LP/J MGP_LPJ_G0021284
protein coding gene Chr14:51138534-51140961 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021216
protein coding gene Chr14:53509005-53511432 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021808
protein coding gene Chr14:50048188-50050615 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0020694
protein coding gene Chr14:50315303-50317730 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display an increased succeptibility to parasitic infections which cause increased numbers of intestinal mucosal mast cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022227 Ensembl Gene Model | MGI Sequence Detail 2414 C57BL/6J ±  kb
transcript ENSMUST00000022836 Ensembl | MGI Sequence Detail 1014 Not Applicable  
polypeptide ENSMUSP00000022836 Ensembl | MGI Sequence Detail 246 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    Genomic 9
    cDNA 6

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-12143, MGD-MRK-12151, MGI:2145776
References
more
  • Summaries
    All 48
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:17707 Reynolds DS, et al., Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases. Proc Natl Acad Sci U S A. 1990 Apr;87(8):3230-4
  • Latest
    J:219149 Li B, et al., Dihydro-CDDO-trifluoroethyl amide suppresses inflammatory responses in macrophages via activation of Nrf2. Biochem Biophys Res Commun. 2014 Feb 21;444(4):555-61

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/13/2019
MGI 6.14
The Jackson Laboratory