Mcpt1
Gene Detail

Symbol Name ID

Mcpt1 mast cell protease 1 MGI:96937

Synonyms

Mcp-1, vascular chymase

Feature Type

protein coding gene

Genetic Map

Chromosome 14

28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr14:56017964-56020391 bp, + strand From NCBI annotation of GRCm38   2428 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:114536  Vertebrate Homology Class
1 mouse; 7 rat

Protein SuperFamily: trypsin
Gene Tree: Mcpt1

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for disruptions in this gene display an increased succeptibility to parasitic infections which cause increased numbers of intestinal mucosal mast cells.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	proteolysis
Component	extracellular region, intracellular
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) Genomic(9) cDNA(5)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000022227 (Evidence)
Entrez Gene	17224 (Evidence)
UniGene	201549
DFCI	TC1591678
DoTS	DT.55282920
EC	3.4.21.-
Consensus CDS Project	CCDS27137.1
International Mouse Knockout Project Status	Mcpt1

Sequences

Length	Strain/Species
genomic	17224	NCBI Gene Model | MGI Sequence Detail	2428	C57BL/6J
transcript	NM_008570	RefSeq | MGI Sequence Detail	1028	BALB/c
polypeptide	P11034	UniProt | EBI | MGI Sequence Detail	246	Not Applicable

All sequences(17) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(75 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
Protein Ontology	PR:000010902	mast cell protease 1

Graphical View of Protein Domain Structure

References

(Earliest) J:17707 Reynolds DS, et al., Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases. Proc Natl Acad Sci U S A. 1990 Apr;87(8):3230-4
(Latest) J:184504 Sugimoto K, et al., The alphavbeta6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells. J Clin Invest. 2012 Feb 1;122(2):748-58
All references(44)

Other accession IDs

MGD-MRK-12143, MGD-MRK-12151, MGI:2145776