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Mcpt1
Gene Detail
 Symbol
Name
ID
Mcpt1
mast cell protease 1
MGI:96937
Synonyms Mcp-1, vascular chymase
Feature Type protein coding gene
Genetic Map
Chromosome 14
28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr14:56017964-56020391 bp, + strand
From NCBI annotation of GRCm38

  2428 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137209  Vertebrate Homology Class
1 mouse; 3 rat

Protein SuperFamily: trypsin
Gene Tree: Mcpt1

Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display an increased succeptibility to parasitic infections which cause increased numbers of intestinal mucosal mast cells.
 
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Component extracellular region, extracellular space, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) Genomic(9) cDNA(5)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000022227 (Evidence)
Entrez Gene17224 (Evidence)
UniGene201549
DFCITC1591678
DoTSDT.55282920
EC3.4.21.-
Consensus CDS ProjectCCDS27137.1
International Mouse Knockout Project StatusMcpt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17224 NCBI Gene Model | MGI Sequence Detail 2428 C57BL/6J ±  kb
transcript NM_008570 RefSeq | MGI Sequence Detail 1028 BALB/c 
polypeptide P11034 UniProt | EBI | MGI Sequence Detail 246 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(106 from dbSNP Build 137)    SNPs within 2kb including multiple locations(132)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000010902 mast cell protease 1
Graphical View of Protein Domain Structure
References (Earliest) J:17707 Reynolds DS, et al., Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases. Proc Natl Acad Sci U S A. 1990 Apr;87(8):3230-4
(Latest) J:194920 Poddar D, et al., An extraribosomal function of ribosomal protein l13a in macrophages resolves inflammation. J Immunol. 2013 Apr 1;190(7):3600-12
All references(46)
Other
accession IDs
MGD-MRK-12143, MGD-MRK-12151, MGI:2145776

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory