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Mcpt1
Gene Detail
Symbol

Name
ID
Mcpt1
mast cell protease 1
MGI:96937
Synonyms
Mcp-1, vascular chymase
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr14:56017964-56020391 bp, + strand
From NCBI annotation of GRCm38

  2428 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137209  Vertebrate Homology Class
1 mouse; 3 rat

Protein SuperFamily: trypsin
Gene Tree: Mcpt1

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(3) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display an increased succeptibility to parasitic infections which cause increased numbers of intestinal mucosal mast cells.
 
Interactions
Mcpt1 interacts with 44 markers (Mir98, Mir100, Mir153, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cellular response to drug, protein processing, ...
Component extracellular region, extracellular space, ...
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(9) cDNA(5)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000022227 (Evidence)
Entrez Gene 17224 (Evidence)
UniGene 201549
DFCI TC1591678
DoTS DT.55282920
EC 3.4.21.-
Consensus CDS Project CCDS27137.1
International Mouse Phenotyping Consortium Status Mcpt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17224 NCBI Gene Model | MGI Sequence Detail 2428 C57BL/6J ±  kb
transcript NM_008570 RefSeq | MGI Sequence Detail 1028 BALB/c 
polypeptide P11034 UniProt | EBI | MGI Sequence Detail 246 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(106 from dbSNP Build 137)    SNPs within 2kb including multiple locations(132)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000010902 mast cell protease 1
Graphical View of Protein Domain Structure
References
(Earliest) J:17707 Reynolds DS, et al., Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases. Proc Natl Acad Sci U S A. 1990 Apr;87(8):3230-4
(Latest) J:219149 Li B, et al., Dihydro-CDDO-trifluoroethyl amide suppresses inflammatory responses in macrophages via activation of Nrf2. Biochem Biophys Res Commun. 2014 Feb 21;444(4):555-61
All references(46)
Other
accession IDs
MGD-MRK-12143, MGD-MRK-12151, MGI:2145776

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory