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Mcf2
Gene Detail
 Symbol
Name
ID
Mcf2
mcf.2 transforming sequence
MGI:96932
Synonyms B230117G22Rik, Dbl
Feature Type protein coding gene
Genetic Map
Chromosome X
33.50 cM, cytoband A6/A7
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
ChrX:60055956-60179089 bp, - strand
From VEGA annotation of GRCm38

  123134 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3917  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: dbl transforming protein
Gene Tree: Mcf2

Human
homologs
Human Homolog MCF2, MCF.2 cell line derived transforming sequence
NCBI Gene ID 4168
neXtProt AC  NX_P10911
Human Synonyms  ARHGEF21, DBL
Human Chr (Location)  Xq27; chrX:139581771-139708222 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(17) Targeted(4)
Incidental mutations (data from APF )
 
Homozygous and hemizygous null mice are viable, fertile and behaviorally normal, exhibit normal gonad and brain development and neuronal migration, but show a significant reduction of basal dendritic length in distinct subpopulations of cortical pyramidal neurons.
 
Interactions
Mcf2 interacts with 176 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process dendrite development, positive regulation of GTPase activity
Component extracellular vesicular exosome
Function guanyl-nucleotide exchange factor activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (4)    Tissues (3)    Images (2)
Theiler Stages: 23
Assay TypeResults
RNA in situ 4
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000018385 (Evidence)
Ensembl Gene ModelENSMUSG00000031139 (Evidence)
Entrez Gene109904 (Evidence)
UniGene93796
DFCITC1586321, TC1664999
DoTSDT.101238233, DT.101724832, DT.94223697, DT.97386479
NIA Mouse Gene IndexU039411
Consensus CDS ProjectCCDS30160.1, CCDS72384.1
International Mouse Knockout Project StatusMcf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018385 VEGA Gene Model | MGI Sequence Detail 123134 C57BL/6J ±  kb
transcript OTTMUST00000044378 VEGA | MGI Sequence Detail 4227 Not Applicable 
polypeptide OTTMUSP00000019937 VEGA | MGI Sequence Detail 1111 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(22) UniProt(7)
Polymorphisms RFLP(4) : SNPs within 2kb(200 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001251 CRAL-TRIO domain
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR018159 Spectrin/alpha-actinin
Protein Ontology PR:000010237 proto-oncogene DBL
References (Earliest) J:30981 Eva A, et al., Isolation of a new human oncogene from a diffuse B-cell lymphoma. Nature. 1985 Jul 18-24;316(6025):273-5
(Latest) J:208273 Zihni C, et al., Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation. J Cell Biol. 2014 Jan 6;204(1):111-27
All references(41)
Other
accession IDs
MGD-MRK-12134, MGD-MRK-12135, MGI:2444059

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory