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Mcf2
Gene Detail
Symbol

Name
ID
Mcf2
mcf.2 transforming sequence
MGI:96932
Synonyms
B230117G22Rik, Dbl
Feature Type
protein coding gene
Genetic Map
Chromosome X
33.50 cM, cytoband A6/A7
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
ChrX:60055956-60179089 bp, - strand
From VEGA annotation of GRCm38

  123134 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3917  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MCF2
Protein SuperFamily: dbl transforming protein
Gene Tree: Mcf2

Human
homologs
MCF2, MCF.2 cell line derived transforming sequence
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4168
neXtProt AC: NX_P10911

Human Synonyms: ARHGEF21, DBL

Human Chr (Location): Xq27; chrX:139581771-139708243 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(17) Targeted(4)
Incidental mutations (data from APF , CvDC )
 
Homozygous and hemizygous null mice are viable, fertile and behaviorally normal, exhibit normal gonad and brain development and neuronal migration, but show a significant reduction of basal dendritic length in distinct subpopulations of cortical pyramidal neurons.
 
Interactions
Mcf2 interacts with 175 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (4)    Tissues (3)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 4
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MCF2 ; Xenbase mcf2    NEW 
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000018385 (Evidence)
Ensembl Gene Model ENSMUSG00000031139 (Evidence)
Entrez Gene 109904 (Evidence)
UniGene 93796
DFCI TC1586321, TC1664999
DoTS DT.101238233, DT.101724832, DT.94223697, DT.97386479
NIA Mouse Gene Index U039411
Consensus CDS Project CCDS30160.1, CCDS72384.1
International Mouse Phenotyping Consortium Status Mcf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018385 VEGA Gene Model | MGI Sequence Detail 123134 C57BL/6J ±  kb
transcript OTTMUST00000044378 VEGA | MGI Sequence Detail 4227 Not Applicable 
polypeptide OTTMUSP00000019937 VEGA | MGI Sequence Detail 1111 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(11) UniProt(7)
Polymorphisms
RFLP(4) : SNPs within 2kb(200 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001251 CRAL-TRIO domain
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR018159 Spectrin/alpha-actinin
Protein Ontology PR:000010237 proto-oncogene DBL
References
(Earliest) J:30981 Eva A, et al., Isolation of a new human oncogene from a diffuse B-cell lymphoma. Nature. 1985 Jul 18-24;316(6025):273-5
(Latest) J:208886 Ramasamy SK, et al., Endothelial Notch activity promotes angiogenesis and osteogenesis in bone. Nature. 2014 Mar 20;507(7492):376-80
All references(41)
Other
accession IDs
MGD-MRK-12134, MGD-MRK-12135, MGI:2444059

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory