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Mcc Gene Detail
Summary
  • Symbol
    Mcc
  • Name
    mutated in colorectal cancers
  • Synonyms
    D18Ertd451e
  • Feature Type
    protein coding gene
  • IDs
    MGI:96930
    NCBI Gene: 328949
  • Gene Overview
    MyGene.info: MCC
Location & Maps
more
  • Sequence Map
    Chr18:44425060-44812182 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      387123 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 23.74 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    MCC, mutated in colorectal cancers
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MCC, mutated in colorectal cancers
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MCC1
  • Links
    NCBI Gene ID: 4163
    neXtProt AC: NX_P23508

  • Chr Location
    5q22.2; chr5:113022099-113488830 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 20539
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MCC
  • Gene Tree
    Mcc
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 1 genetic background
    7 phenotype references
Mice homozygous for hypomorphic or null mutations are viable and fertile with no gross abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055565 VEGA Gene Model | MGI Sequence Detail 387123 C57BL/6J ±  kb
transcript OTTMUST00000137522 VEGA | MGI Sequence Detail 7858 Not Applicable  
polypeptide OTTMUSP00000072414 VEGA | MGI Sequence Detail 1003 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3502 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR018247 EF-Hand 1, calcium-binding site
    IPR002048 EF-hand domain
    IPR011992 EF-hand domain pair
    IPR019536 Usher syndrome type-1C protein-binding protein 1, PDZ domain
Molecular
Reagents
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  • All nucleic 18
    Genomic 1
    cDNA 8
    Primer pair 8
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-12132, MGI:1196414
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 1
    Phenotypes 7
  • Earliest
    J:15307 Kinzler KW, et al., Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers [see comments]. Science. 1991 Mar 15;251(4999):1366-70
  • Latest
    J:177409 Young T, et al., Mutated in colorectal cancer (Mcc), a candidate tumor suppressor, is dynamically expressed during mouse embryogenesis. Dev Dyn. 2011 Sep;240(9):2166-74

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory