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Mcc Gene Detail
Summary
  • Symbol
    Mcc
  • Name
    mutated in colorectal cancers
  • Synonyms
    D18Ertd451e
  • Feature Type
    protein coding gene
  • IDs
    MGI:96930
    NCBI Gene: 328949
  • Gene Overview
    MyGene.info: MCC
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:44425060-44812182 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 23.74 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3502 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96930
protein coding gene Chr18:44425060-44812182 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024401
protein coding gene Chr18:43166087-43575333 (-)
A/J MGP_AJ_G0024368
protein coding gene Chr18:41621557-42013518 (-)
AKR/J MGP_AKRJ_G0024337
protein coding gene Chr18:42795621-43193735 (-)
BALB/cJ MGP_BALBcJ_G0024368
protein coding gene Chr18:41715147-42109261 (-)
C3H/HeJ MGP_C3HHeJ_G0024135
protein coding gene Chr18:42822180-43237514 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024812
protein coding gene Chr18:44660601-45069596 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022247
protein coding gene Chr18:41413009-41789229 (-)
CAST/EiJ MGP_CASTEiJ_G0023609
protein coding gene Chr18:42820482-43225306 (-)
CBA/J MGP_CBAJ_G0024104
protein coding gene Chr18:45881231-46307045 (-)
DBA/2J MGP_DBA2J_G0024234
protein coding gene Chr18:41241956-41613583 (-)
FVB/NJ MGP_FVBNJ_G0024200
protein coding gene Chr18:40837272-41221420 (-)
LP/J MGP_LPJ_G0024318
protein coding gene Chr18:43195975-43622470 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024231
protein coding gene Chr18:47252471-47664613 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024859
protein coding gene Chr18:42668307-43077841 (-)
PWK/PhJ MGP_PWKPhJ_G0023353
protein coding gene Chr18:41429778-41814498 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023157
protein coding gene Chr18:42809553-43286558 (-)
WSB/EiJ MGP_WSBEiJ_G0023672
protein coding gene Chr18:42589907-42986554 (-)



Homology
more
  • Human Ortholog
    MCC, MCC regulator of WNT signaling pathway
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MCC, MCC regulator of WNT signaling pathway
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MCC1
  • Links
    NCBI Gene ID: 4163
    neXtProt AC: NX_P23508
    UniProt: P23508

  • Chr Location
    5q22.2; chr5:113022099-113488830 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 20539
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MCC
  • Gene Tree
    Mcc
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 1 genetic background
    7 phenotype references
Mice homozygous for hypomorphic or null mutations are viable and fertile with no gross abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 328949 NCBI Gene Model | MGI Sequence Detail 387123 C57BL/6J ±  kb
transcript NM_001085373 RefSeq | MGI Sequence Detail 7875 C57BL/6  
polypeptide NP_001078842 RefSeq | MGI Sequence Detail 1003 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR018247 EF-Hand 1, calcium-binding site
    IPR002048 EF-hand domain
    IPR011992 EF-hand domain pair
    IPR040171 Usher syndrome type-1C protein-binding protein 1-like
    IPR019536 Usher syndrome type-1C protein-binding protein 1, PDZ domain
Molecular
Reagents
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  • All nucleic 19
    Genomic 1
    cDNA 9
    Primer pair 8
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-12132, MGI:1196414
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 1
    Phenotypes 7
  • Earliest
    J:15307 Kinzler KW, et al., Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers [see comments]. Science. 1991 Mar 15;251(4999):1366-70
  • Latest
    J:237465 Cheverud JM, et al., Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line. Heredity (Edinb). 2014 May;112(5):508-18

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory