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Mb Gene Detail
Summary
  • Symbol
    Mb
  • Name
    myoglobin
  • Feature Type
    protein coding gene
  • IDs
    MGI:96922
    NCBI Gene: 17189
  • Gene Overview
    MyGene.info: MB
Location & Maps
more
  • Sequence Map
    Chr15:77015487-77050668 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      35182 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 36.36 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    MB, myoglobin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MB, myoglobin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    myoglobgin, PVALB
  • Links
    NCBI Gene ID: 4151
    neXtProt AC: NX_P02144

  • Chr Location
    22q13.1; chr22:35606764-35623354 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3916
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish
  • HCOP
    human homology predictions: MB
  • Protein SuperFamily
  • Gene Tree
    Mb
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 2 alleles in 4 genetic backgrounds
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    3
  • Gene trapped
    12
  • Radiation induced
    2
  • Targeted
    6
  • Genomic Mutations
    5 involving Mb
Homozygotes for a null allele show increased cardiac capillary density, coronary flow, hemoglobin and hematocrit levels. Many mice homozygous for another null allele die of heart failure at midgestation; survivors show hypervascularity, altered NO metabolism, and hypoxia-induced cardiac dysfunction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17189 NCBI Gene Model | MGI Sequence Detail 35182 C57BL/6J ±  kb
transcript NM_001164047 RefSeq | MGI Sequence Detail 1121 C57BL/6  
polypeptide P04247 UniProt | EBI | MGI Sequence Detail 154 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    158 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 347
    Genomic 4
    cDNA 337
    Primer pair 5
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-12122, MGI:2145982
References
more
  • Summaries
    All 63
    Developmental Gene Expression 14
    Diseases 1
    Gene Ontology 7
    Phenotypes 42
  • Earliest
    J:15351 Blanchetot A, et al., The mouse myoglobin gene. Characterisation and sequence comparison with other mammalian myoglobin genes. Eur J Biochem. 1986 Sep 15;159(3):469-74
  • Latest
    J:228946 Wei N, et al., SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing. Cell Rep. 2015 Nov 24;13(8):1647-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory