Mb
Gene Detail

Symbol Name ID

Mb myoglobin MGI:96922

Feature Type

protein coding gene

Genetic Map

Chromosome 15

36.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr15:77015487-77050668 bp, - strand From NCBI annotation of GRCm38   35182 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3916  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: globin
Gene Tree: Mb

Human homologs

Human Homolog		MB, myoglobin
NCBI Gene ID		4151
neXtProt AC		NX_P02144
Human Synonyms		PVALB
Human Chr (Location)		22q13.1; chr22:36002811-36019401 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(17) : Targeted(5) Gene trapped(12)
 

Homozygotes for a null allele show increased cardiac capillary density, coronary flow, hemoglobin and hematocrit levels. Many mice homozygous for another null allele die of heart failure at midgestation; survivors show hypervascularity, altered NO metabolism, and hypoxia-induced cardiac dysfunction.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	brown fat cell differentiation, enucleate erythrocyte differentiation, ...
Function	heme binding, iron ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (36)    Tissues (8)    Images (14)
Theiler Stages: 20, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	17
Northern blot	4
RT-PCR	15

cDNA source data(333)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(343) Genomic(4) cDNA(334) Primer pair(5)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000018893 (Evidence)
Entrez Gene	17189 (Evidence)
UniGene	404074
DFCI	TC1575720
DoTS	DT.101371788, DT.94398415, DT.94398417
NIA Mouse Gene Index	U036363
Consensus CDS Project	CCDS27597.1
International Mouse Knockout Project Status	Mb

Sequences

Length	Strain/Species
genomic	17189	NCBI Gene Model | MGI Sequence Detail	35182	C57BL/6J
transcript	NM_001164047	RefSeq | MGI Sequence Detail	1121	C57BL/6
polypeptide	P04247	UniProt | EBI | MGI Sequence Detail	154	Not Applicable

All sequences(28) RefSeq(6) UniProt(2)

Polymorphisms

PCR(2) : SNPs(142 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000971	Globin
InterPro	IPR009050	Globin-like
InterPro	IPR012292	Globin, structural domain
InterPro	IPR002335	Myoglobin
Protein Ontology	PR:000010213	myoglobin

Graphical View of Protein Domain Structure

References

(Earliest) J:15351 Blanchetot A, et al., The mouse myoglobin gene. Characterisation and sequence comparison with other mammalian myoglobin genes. Eur J Biochem. 1986 Sep 15;159(3):469-74
(Latest) J:186039 Ormerod JO, et al., The role of vascular myoglobin in nitrite-mediated blood vessel relaxation. Cardiovasc Res. 2011 Feb 15;89(3):560-5
All references(64)

Other accession IDs

MGD-MRK-12122, MGI:2145982