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Mb
Gene Detail
Symbol

Name
ID
Mb
myoglobin
MGI:96922
Feature Type
protein coding gene
Genetic Map
Chromosome 15
36.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:77015487-77050668 bp, - strand
From NCBI annotation of GRCm38

  35182 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3916  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: MB
Protein SuperFamily: globin
Gene Tree: Mb

Human
homologs
MB, myoglobin
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4151
neXtProt AC: NX_P02144

Human Synonyms: myoglobgin, PVALB

Human Chr (Location): 22q13.1; chr22:35606764-35623354 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(12) Radiation induced(1) Targeted(6)
Genomic Mutations involving Mb (1)
 
Homozygotes for a null allele show increased cardiac capillary density, coronary flow, hemoglobin and hematocrit levels. Many mice homozygous for another null allele die of heart failure at midgestation; survivors show hypervascularity, altered NO metabolism, and hypoxia-induced cardiac dysfunction.
 
Phenotype Images(2)
Interactions
Mb interacts with 39 markers (Mir18b, Mir26a-2, Mir26b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process brown fat cell differentiation, enucleate erythrocyte differentiation, ...
Component extracellular exosome
Function heme binding, iron ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (36)    Tissues (8)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 17
Northern blot 4
RT-PCR 15
cDNA source data(336)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN mb    NEW 
Molecular
reagents
All nucleic(346) Genomic(4) cDNA(337) Primer pair(5)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000018893 (Evidence)
Entrez Gene 17189 (Evidence)
UniGene 404074
DFCI TC1575720
DoTS DT.101371788, DT.94398415, DT.94398417
NIA Mouse Gene Index U036363
Consensus CDS Project CCDS27597.1
International Mouse Phenotyping Consortium Status Mb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17189 NCBI Gene Model | MGI Sequence Detail 35182 C57BL/6J ±  kb
transcript NM_001164047 RefSeq | MGI Sequence Detail 1121 C57BL/6 
polypeptide P04247 UniProt | EBI | MGI Sequence Detail 154 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(6) UniProt(2)
Polymorphisms
PCR(2) : SNPs within 2kb(159 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000971 Globin
InterPro IPR009050 Globin-like
InterPro IPR012292 Globin, structural domain
InterPro IPR002335 Myoglobin
Protein Ontology PR:000010213 myoglobin
Graphical View of Protein Domain Structure
References
(Earliest) J:15351 Blanchetot A, et al., The mouse myoglobin gene. Characterisation and sequence comparison with other mammalian myoglobin genes. Eur J Biochem. 1986 Sep 15;159(3):469-74
(Latest) J:186039 Ormerod JO, et al., The role of vascular myoglobin in nitrite-mediated blood vessel relaxation. Cardiovasc Res. 2011 Feb 15;89(3):560-5
All references(66)
Other
accession IDs
MGD-MRK-12122, MGI:2145982

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory