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Max
Gene Detail
 Symbol
Name
ID
Max
Max protein
MGI:96921
Synonyms bHLHd4, bHLHd5, bHLHd6, bHLHd7, bHLHd8
Feature Type protein coding gene
Genetic Map
Chromosome 12
33.78 cM, cytoband D1-D3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:76937269-76962248 bp, - strand
From NCBI annotation of GRCm38

  24980 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1786  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Myc-associated factor X
Gene Tree: Max

Human
homologs
Human Homolog MAX, MYC associated factor X
NCBI Gene ID 4149
neXtProt AC  NX_P61244
Human Synonyms  bHLHd4
Human Chr (Location)  14q23; chr14:65006101-65102695 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MAX
Mutations,
alleles, and
phenotypes
All mutations/alleles(46) : Gene trapped(43) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation die between E5.5 and 6.5 displaying a generalized developmental arrest of both embryonic and extraembryonic tissues. These defects are not associated with inappropriate apoptosis, but rather with a failure of cells to divide.
 
Interactions
Max interacts with 271 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process negative regulation of gene expression, protein complex assembly, ...
Component cell projection, cytoplasm, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (127)    Tissues (77)    Images (9)
Theiler Stages: 2, 3, 4, 5, 15, 16, 17, 20, 21, 23, 27, 28
Assay TypeResults
RNA in situ 51
RT-PCR 74
RNase protection 2
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(10) Primer pair(4) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000059436 (Evidence)
Entrez Gene17187 (Evidence)
DFCITC1573033, TC1584430
DoTSDT.101317045, DT.110939204, DT.536740
NIA Mouse Gene IndexU034094
PDB3U5V, 1A93, 2A93
Consensus CDS ProjectCCDS36479.1, CCDS49094.1
International Mouse Knockout Project StatusMax
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17187 NCBI Gene Model | MGI Sequence Detail 24980 C57BL/6J ±  kb
transcript NM_008558 RefSeq | MGI Sequence Detail 2005 C57BL/6 
polypeptide P28574 UniProt | EBI | MGI Sequence Detail 160 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(9) UniProt(3)
Polymorphisms SNPs within 2kb(152 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000010211 protein max
Graphical View of Protein Domain Structure
References (Earliest) J:19399 Blackwood EM, et al., Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science. 1991 Mar 8;251(4998):1211-7
(Latest) J:195485 Chappell J, et al., MYC/MAX control ERK signaling and pluripotency by regulation of dual-specificity phosphatases 2 and 7. Genes Dev. 2013 Apr 1;27(7):725-33
All references(60)
Other
accession IDs
MGD-MRK-12121, MGI:2144751, MGI:2144915

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory