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Maob Gene Detail
Summary
  • Symbol
    Maob
  • Name
    monoamine oxidase B
  • Synonyms
    6330414K01Rik, MAO-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:96916
    NCBI Gene: 109731
  • Gene Overview
    MyGene.info: MAOB
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:16709282-16817366 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 11.88 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    245 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96916
protein coding gene ChrX:16709281-16817366 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035580
protein coding gene ChrX:11559323-11679341 (-)
A/J MGP_AJ_G0035557
protein coding gene ChrX:11647104-11778621 (-)
AKR/J MGP_AKRJ_G0035489
protein coding gene ChrX:12022334-12144982 (-)
BALB/cJ MGP_BALBcJ_G0035550
protein coding gene ChrX:11469674-11583236 (-)
C3H/HeJ MGP_C3HHeJ_G0035267
protein coding gene ChrX:11699955-11811184 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036085
protein coding gene ChrX:11856485-11973108 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032950
protein coding gene ChrX:10216562-10326218 (-)
CAST/EiJ MGP_CASTEiJ_G0034559
protein coding gene ChrX:11256623-11374658 (-)
CBA/J MGP_CBAJ_G0035236
protein coding gene ChrX:12402875-12527410 (-)
DBA/2J MGP_DBA2J_G0035388
protein coding gene ChrX:11502482-11608154 (-)
FVB/NJ MGP_FVBNJ_G0035335
protein coding gene ChrX:11371394-11491061 (-)
LP/J MGP_LPJ_G0035470
protein coding gene ChrX:11848892-11962218 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035379
protein coding gene ChrX:12512213-12640372 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036092
protein coding gene ChrX:11489744-11600965 (-)
PWK/PhJ MGP_PWKPhJ_G0034260
protein coding gene ChrX:10833218-10941546 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034099
protein coding gene ChrX:11485753-11608468 (-)
WSB/EiJ MGP_WSBEiJ_G0034694
protein coding gene ChrX:11460787-11570371 (-)



Homology
more
  • Human Ortholog
    MAOB, monoamine oxidase B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAOB, monoamine oxidase B
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 4129
    neXtProt AC: NX_P27338
    UniProt: P27338

  • Chr Location
    Xp11.3; chrX:43766610-43882475 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 20251
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MAOB
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    13 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased brain levels and urinary excretion of beta-phenylethylamine, stress-induced hyperactivity, and decreased susceptibility to dopaminergic neuron neurotoxicity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040147 Ensembl Gene Model | MGI Sequence Detail 108085 C57BL/6J ±  kb
    transcript ENSMUST00000040820 Ensembl | MGI Sequence Detail 2411 Not Applicable  
    polypeptide ENSMUSP00000040550 Ensembl | MGI Sequence Detail 520 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 49

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-12112, MGI:2443774
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 5
      Phenotypes 21
    • Earliest
      J:10089 Derry JM, et al., Localization of monoamine oxidase A and B genes on the mouse X chromosome. Nucleic Acids Res. 1989 Oct 25;17(20):8403
    • Latest
      J:265325 Kang SS, et al., alpha-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease. EMBO J. 2018 Jun 15;37(12)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory