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Maob Gene Detail
Summary
  • Symbol
    Maob
  • Name
    monoamine oxidase B
  • Synonyms
    6330414K01Rik, MAO-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:96916
    NCBI Gene: 109731
Location & Maps
more
  • Sequence Map
    ChrX:16709282-16817366 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      108085 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MAOB, monoamine oxidase B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAOB, monoamine oxidase B
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 4129
    neXtProt AC: NX_P27338

  • Chr Location
    Xp11.23; chrX:43766610-43882475 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 20251
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MAOB
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    12 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Targeted
    2
  • Transgenic
    1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit increased brain levels and urinary excretion of beta-phenylethylamine, stress-induced hyperactivity, and decreased susceptibility to dopaminergic neuron neurotoxicity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016927 VEGA Gene Model | MGI Sequence Detail 108085 C57BL/6J ±  kb
transcript OTTMUST00000041060 VEGA | MGI Sequence Detail 2411 Not Applicable  
polypeptide OTTMUSP00000018395 VEGA | MGI Sequence Detail 520 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    246 from dbSNP Build 137
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 48
    cDNA 48

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-12112, MGI:2443774
References
more
  • Summaries
    All 50
    Developmental Gene Expression 8
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:10089 Derry JM, et al., Localization of monoamine oxidase A and B genes on the mouse X chromosome. Nucleic Acids Res. 1989 Oct 25;17(20):8403
  • Latest
    J:211207 Wang CC, et al., Serotonin receptor 6 mediates defective brain development in monoamine oxidase A-deficient mouse embryos. J Biol Chem. 2014 Mar 21;289(12):8252-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory