Mak
Gene Detail

Symbol Name ID

Mak male germ cell-associated kinase MGI:96913

Synonyms

A930010O05Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 13

20.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr13:41025120-41079706 bp, - strand From NCBI annotation of GRCm38   54587 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31344  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mak

Human homologs

Human Homolog		MAK, male germ cell-associated kinase
NCBI Gene ID		4117
neXtProt AC		NX_P20794
Human Synonyms		dJ417M14.2, RP62
Human Chr (Location)		6p24; chr6:10762956-10838788 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MAK

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Males homozygous for a targeted null mutation exhibit slight reductions in litter size and sperm motility in vitro.

 

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	phosphorylation, photoreceptor cell maintenance, ...
Component	cell projection, centrosome, ...
Function	ATP binding, cyclin-dependent protein serine/threonine kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (11)    Tissues (6)    Images (17)
Theiler Stages: 22, 24, 26, 28

Assay Type	Results
RNA in situ	11

cDNA source data(29)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(32) Genomic(1) cDNA(30) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000021363 (Evidence)
Entrez Gene	17152 (Evidence)
UniGene	8149
DFCI	TC1582824, TC1588191, TC1615030
DoTS	DT.101365351, DT.101724429, DT.40140883, DT.94185364
NIA Mouse Gene Index	U103505
EC	2.7.11.22
Consensus CDS Project	CCDS26471.1, CCDS49244.1, CCDS49245.1
International Mouse Knockout Project Status	Mak

Sequences

Length	Strain/Species
genomic	17152	NCBI Gene Model | MGI Sequence Detail	54587	C57BL/6J
transcript	NM_001145803	RefSeq | MGI Sequence Detail	3562	C57BL/6
polypeptide	Q04859	UniProt | EBI | MGI Sequence Detail	622	Not Applicable

All sequences(30) RefSeq(6) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(267 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000010089	serine/threonine-protein kinase MAK

Graphical View of Protein Domain Structure

References

(Earliest) J:10426 Matsushime H, et al., A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis. Mol Cell Biol. 1990 May;10(5):2261-8
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(32)

Other accession IDs

MGD-MRK-12106, MGI:2444483