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Mak
Gene Detail
 Symbol
Name
ID
Mak
male germ cell-associated kinase
MGI:96913
Synonyms A930010O05Rik
Feature Type protein coding gene
Genetic Map
Chromosome 13
20.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:41025120-41079706 bp, - strand
From NCBI annotation of GRCm38

  54587 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31344  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mak

Human
homologs
Human Homolog MAK, male germ cell-associated kinase
NCBI Gene ID 4117
neXtProt AC  NX_P20794
Human Synonyms  dJ417M14.2, RP62
Human Chr (Location)  6p24; chr6:10762723-10838555 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MAK
Alleles
and
phenotypes
All alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Males homozygous for a targeted null mutation exhibit slight reductions in litter size and sperm motility in vitro.
 
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process phosphorylation, photoreceptor cell maintenance, ...
Component cell projection, centrosome, ...
Function ATP binding, cyclin-dependent protein serine/threonine kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (11)    Tissues (6)    Images (17)
Theiler Stages: 22, 24, 26, 28
Assay TypeResults
RNA in situ 11
cDNA source data(29)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(32) Genomic(1) cDNA(30) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000021363 (Evidence)
Entrez Gene17152 (Evidence)
UniGene8149
DFCITC1582824, TC1588191, TC1615030
DoTSDT.101365351, DT.101724429, DT.40140883, DT.94185364
NIA Mouse Gene IndexU103505
EC2.7.11.22
Consensus CDS ProjectCCDS26471.1, CCDS49244.1, CCDS49245.1
International Mouse Knockout Project StatusMak
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17152 NCBI Gene Model | MGI Sequence Detail 54587 C57BL/6J ±  kb
transcript NM_001145803 RefSeq | MGI Sequence Detail 3562 C57BL/6 
polypeptide Q04859 UniProt | EBI | MGI Sequence Detail 622 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(18) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(376 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010089 serine/threonine-protein kinase MAK
Graphical View of Protein Domain Structure
References (Earliest) J:10426 Matsushime H, et al., A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis. Mol Cell Biol. 1990 May;10(5):2261-8
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(32)
Other
accession IDs
MGD-MRK-12106, MGI:2444483

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory