About   Help   FAQ
Mag
Gene Detail
Symbol

Name
ID
Mag
myelin-associated glycoprotein
MGI:96912
Synonyms
Gma, siglec-4a
Feature Type
protein coding gene
Genetic Map
Chromosome 7
19.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)
Sequence Map
Chr7:30899176-30914873 bp, - strand
From VEGA annotation of GRCm38

  15698 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1771  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: myelin-associated glycoprotein
Gene Tree: Mag

Human
homologs
Human Homolog MAG, myelin associated glycoprotein
NCBI Gene ID 4099
neXtProt AC  NX_P20916
Human Synonyms  GMA, SIGLEC4A, SIGLEC-4A, S-MAG
Human Chr (Location)  19q13.1; chr19:35292086-35313807 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit delayed CNS myelination, late myelin degeneration in peripheral nerves, hypomyelination of optic nerves, and subtle intention tremors.
 
Interactions
Mag interacts with 128 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cell adhesion
Component integral component of membrane, membrane, ...
Function carbohydrate binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (36 records)
Data Summary: Results (92)    Tissues (75)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 30
Western blot 11
RT-PCR 48
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) Genomic(7) cDNA(24) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000049785 (Evidence)
Ensembl Gene ModelENSMUSG00000036634 (Evidence)
Entrez Gene17136 (Evidence)
UniGene241355
DFCITC1581023, TC1606820, TC1756427
DoTSDT.101366368, DT.526835, DT.99856277
NIA Mouse Gene IndexU028404
Consensus CDS ProjectCCDS21115.1
International Mouse Knockout Project StatusMag
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049785 VEGA Gene Model | MGI Sequence Detail 15698 C57BL/6J ±  kb
transcript OTTMUST00000126804 VEGA | MGI Sequence Detail 2007 Not Applicable 
polypeptide OTTMUSP00000068554 VEGA | MGI Sequence Detail 627 Not Applicable 

For the selected sequences
All sequences(88) RefSeq(16) UniProt(13)
Polymorphisms
RFLP(4) : SNPs within 2kb(187 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000010052 myelin-associated glycoprotein
References
(Earliest) J:31033 Gilman AG, G proteins and dual control of adenylate cyclase. Cell. 1984 Mar;36(3):577-9
(Latest) J:201967 Lin ST, et al., MicroRNA-23a promotes myelination in the central nervous system. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17468-73
All references(157)
Other
accession IDs
MGD-MRK-10172, MGD-MRK-12105

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/21/2014
MGI 5.20
The Jackson Laboratory