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Mag Gene Detail
Summary
  • Symbol
    Mag
  • Name
    myelin-associated glycoprotein
  • Synonyms
    Gma, siglec-4a
  • Feature Type
    protein coding gene
  • IDs
    MGI:96912
    NCBI Gene: 17136
  • Gene Overview
    MyGene.info: MAG
Location & Maps
more
  • Sequence Map
    Chr7:30899176-30914873 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15698 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MAG, myelin associated glycoprotein
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MAG, myelin associated glycoprotein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GMA, SIGLEC4A, SIGLEC-4A, S-MAG, SPG75
  • Links
    NCBI Gene ID: 4099
    neXtProt AC: NX_P20916

  • Chr Location
    19q13.1; chr19:35292086-35313807 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 4 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit delayed CNS myelination, late myelin degeneration in peripheral nerves, hypomyelination of optic nerves, and subtle intention tremors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049785 VEGA Gene Model | MGI Sequence Detail 15698 C57BL/6J ±  kb
transcript OTTMUST00000126804 VEGA | MGI Sequence Detail 2007 Not Applicable  
polypeptide OTTMUSP00000068554 VEGA | MGI Sequence Detail 627 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    187 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 35
    Genomic 7
    cDNA 24
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10172, MGD-MRK-12105
References
more
  • Summaries
    All 158
    Developmental Gene Expression 38
    Gene Ontology 8
    Phenotypes 42
  • Earliest
    J:31033 Gilman AG, G proteins and dual control of adenylate cyclase. Cell. 1984 Mar;36(3):577-9
  • Latest
    J:224552 Watzlawik JO, et al., Polysialic acid as an antigen for monoclonal antibody HIgM12 to treat multiple sclerosis and other neurodegenerative disorders. J Neurochem. 2015 Sep;134(5):865-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory