Maff Gene Detail

Summary

• Symbol
  Maff
• Name
  v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)

• Feature Type
  protein coding gene
• IDs
  MGI:96910
  NCBI Gene: 17133
• Gene Overview
  MyGene.info: MAFF
• Alliance
  gene page

Location & Maps

• Sequence Map
  Chr15:79347541-79359072 bp, + strand
• From Ensembl annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    11532 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 37.70 cM
• Mapping Data
  1 experiment

Homology

• Human Ortholog
  MAFF, MAF bZIP transcription factor F

• Vertebrate Orthologs
  8

• Human Ortholog
  MAFF, MAF bZIP transcription factor F
  Orthology source: HomoloGene, HGNC
• Synonyms
  hMafF, U-MAF
• Links
  HGNC:6780

  NCBI Gene ID: 23764

  neXtProt AC: NX_Q9ULX9

  UniProt: Q9ULX9

  
  
• Chr Location
  22q13.1; chr22:38201932-38216511 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 7825
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 macaque, rhesus
  
• HCOP
  human homology predictions: MAFF
• Protein SuperFamily
  transcription factor MafK
• Gene Tree
  Maff
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 2 alleles in 1 genetic background
  30 phenotype references
  

• All Mutations and Alleles
  12
• Chemically induced (other)
  1
• Gene trapped
  4
• Radiation induced
  2
• Targeted
  5
• Genomic Mutations
  3 involving Maff
• Find Mice (IMSR)
  5 strains or lines available

Homozygous null mice are viable and fertile and show no obvious functional deficiencies.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  13
• GO References
  5

• External Resources
  FuncBase

Expression

• Assay Results
  179
• Tissues
  172
• cDNA Data
  23
• Literature Summary
  8

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA MAFF
  ZFIN maff

Interactions

• Maff interacts with 150 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

Sequences &
Gene Models

• All Sequences
  33
• RefSeq
  14
• UniProt
  4
• CCDS
  CCDS27638.1
• UniGene
  86646

• Ensembl
  ENSMUSG00000042622 (Evidence)
• NCBI Gene
  17133

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000042622	Ensembl Gene Model | MGI Sequence Detail	11532	C57BL/6J
transcript	ENSMUST00000096350	Ensembl | MGI Sequence Detail	1933	Not Applicable
polypeptide	ENSMUSP00000094076	Ensembl | MGI Sequence Detail	156	Not Applicable

Polymorphisms

• SNPs within 2kb
  51 from dbSNP Build 142

• RFLP
  1

Protein
Information

• UniProt
  4 Sequences
• Protein Ontology
  PR:000010049 transcription factor MafF
  (term hierarchy)
• InterPro Domains
  IPR004827 Basic-leucine zipper domain
  IPR004826 Basic leucine zipper domain, Maf-type
  IPR033531 Transcription factor MafF
  IPR024874 Transcription factor Maf family
  IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamily

Molecular
Reagents

• All nucleic 27

  Genomic 1

  cDNA 23

  Primer pair 3

  
  

  Microarray probesets 4

Other
Accession IDs

MGD-MRK-12102

References

• Summaries
  All 58

  Developmental Gene Expression 8

  Diseases 1

  Gene Ontology 5

  Phenotypes 30
• Earliest
  J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
• Latest
  J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9