About   Help   FAQ
Maff
Gene Detail
 Symbol
Name
ID
Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
MGI:96910
Feature Type protein coding gene
Genetic Map
Chromosome 15
37.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:79347678-79359076 bp, + strand
From NCBI annotation of GRCm38

  11399 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7825  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: transcription factor MafK
Gene Tree: Maff

Human
homologs
Human Homolog MAFF, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NCBI Gene ID 23764
neXtProt AC  NX_Q9ULX9
Human Synonyms  hMafF, U-MAF
Human Chr (Location)  22q13.1; chr22:38201932-38216511 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Radiation induced(1) Targeted(5)
Genomic Mutations involving Maff (1)
 
Homozygous null mice are viable and fertile and show no obvious functional deficiencies.
 
Interactions
Maff interacts with 151 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process in utero embryonic development, regulation of epidermal cell differentiation, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (179)    Tissues (172)    Images (17)
Theiler Stages: 9, 11, 13, 15, 17, 19, 20, 21, 22, 23, 25, 27, 28
Assay TypeResults
RNA in situ 125
In situ reporter (knock in) 25
RT-PCR 29
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(23) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000042622 (Evidence)
Entrez Gene17133 (Evidence)
UniGene86646
DFCITC1583975
DoTSDT.101124216, DT.110787444, DT.55217608
NIA Mouse Gene IndexU139783
Consensus CDS ProjectCCDS27638.1
International Mouse Knockout Project StatusMaff
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17133 NCBI Gene Model | MGI Sequence Detail 11399 C57BL/6J ±  kb
transcript NM_010755 RefSeq | MGI Sequence Detail 1800 C57BL/6 
polypeptide O54791 UniProt | EBI | MGI Sequence Detail 156 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(12) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR004826 Basic leucine zipper domain, Maf-type
InterPro IPR008917 Eukaryotic transcription factor, Skn-1-like, DNA-binding
InterPro IPR024874 Transcription factor Maf
Protein Ontology PR:000010049 transcription factor MafF
Graphical View of Protein Domain Structure
References (Earliest) J:16848 Igarashi K, et al., Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins [see comments]. Nature. 1994 Feb 10;367(6463):568-72
(Latest) J:200275 Hirotsu Y, et al., Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks. Nucleic Acids Res. 2012 Nov 1;40(20):10228-39
All references(41)
Other
accession IDs
MGD-MRK-12102

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory