Maff
Gene Detail

Symbol

Name
ID

Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
MGI:96910

Feature Type

protein coding gene

Genetic Map

Chromosome 15
37.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr15:79347541-79359072 bp, + strand From Ensembl annotation of GRCm38   11532 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:7825  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: transcription factor MafK
Gene Tree: Maff

Human
homologs

Human Homolog		MAFF, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NCBI Gene ID		23764
neXtProt AC		NX_Q9ULX9
Human Synonyms		hMafF, U-MAF
Human Chr (Location)		22q13.1; chr22:38201932-38216511 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(10) : Gene trapped(4) Radiation induced(1) Targeted(5)
Genomic Mutations involving Maff (1)
 

Homozygous null mice are viable and fertile and show no obvious functional deficiencies.

 
Phenotype Images(2)

Interactions

Maff interacts with 151 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (12 annotations)

Process	in utero embryonic development, regulation of epidermal cell differentiation, ...
Component	nucleus
Function	DNA binding, sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)

Data Summary: Results (179)    Tissues (172)    Images (17)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	125
In situ reporter (knock in)	25
RT-PCR	29

cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(27) Genomic(1) cDNA(23) Primer pair(3)
Microarray probesets(4)

Other database
links

Ensembl Gene Model	ENSMUSG00000042622 (Evidence)
Entrez Gene	17133 (Evidence)
UniGene	86646
DFCI	TC1583975
DoTS	DT.101124216, DT.110787444, DT.55217608
NIA Mouse Gene Index	U139783
Consensus CDS Project	CCDS27638.1
International Mouse Knockout Project Status	Maff

Sequences

Length	Strain/Species
genomic	ENSMUSG00000042622	Ensembl Gene Model | MGI Sequence Detail	11532	C57BL/6J
transcript	ENSMUST00000096350	Ensembl | MGI Sequence Detail	1933	Not Applicable
polypeptide	ENSMUSP00000094076	Ensembl | MGI Sequence Detail	156	Not Applicable

All sequences(34) RefSeq(12) UniProt(5)

Polymorphisms

RFLP(1) : SNPs within 2kb(48 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR004827	Basic-leucine zipper domain
InterPro	IPR004826	Basic leucine zipper domain, Maf-type
InterPro	IPR008917	Eukaryotic transcription factor, Skn-1-like, DNA-binding
InterPro	IPR024874	Transcription factor Maf
Protein Ontology	PR:000010049	transcription factor MafF

References

(Earliest) J:16848 Igarashi K, et al., Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins [see comments]. Nature. 1994 Feb 10;367(6463):568-72
(Latest) J:214095 Osipovich AB, et al., Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Development. 2014 Aug;141(15):2939-49
All references(42)

Other
accession IDs

MGD-MRK-12102