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Maff Gene Detail
Summary
  • Symbol
    Maff
  • Name
    v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
  • Feature Type
    protein coding gene
  • IDs
    MGI:96910
    NCBI Gene: 17133
  • Gene Overview
    MyGene.info: MAFF
Location & Maps
more
  • Sequence Map
    Chr15:79347541-79359072 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11532 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MAFF, MAF bZIP transcription factor F
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MAFF, MAF bZIP transcription factor F
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hMafF, U-MAF
  • Links
    NCBI Gene ID: 23764
    neXtProt AC: NX_Q9ULX9

  • Chr Location
    22q13.1; chr22:38201932-38216511 (+)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 1 genetic background
    29 phenotype references
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Radiation induced
    2
  • Targeted
    5
  • Genomic Mutations
    3 involving Maff
Homozygous null mice are viable and fertile and show no obvious functional deficiencies.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042622 Ensembl Gene Model | MGI Sequence Detail 11532 C57BL/6J ±  kb
transcript ENSMUST00000163691 Ensembl | MGI Sequence Detail 1905 Not Applicable  
polypeptide ENSMUSP00000131628 Ensembl | MGI Sequence Detail 156 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    51 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010049 transcription factor MafF
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR004826 Basic leucine zipper domain, Maf-type
    IPR024874 Transcription factor Maf
    IPR008917 Transcription factor, Skn-1-like, DNA-binding domain
Molecular
Reagents
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  • All nucleic 27
    Genomic 1
    cDNA 23
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-12102
References
more
  • Summaries
    All 39
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 6
    Phenotypes 29
  • Earliest
    J:16848 Igarashi K, et al., Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins [see comments]. Nature. 1994 Feb 10;367(6463):568-72
  • Latest
    J:214095 Osipovich AB, et al., Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Development. 2014 Aug;141(15):2939-49

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory