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Maff
Gene Detail
Symbol

Name
ID
Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
MGI:96910
Feature Type
protein coding gene
Genetic Map
Chromosome 15
37.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:79347541-79359072 bp, + strand
From Ensembl annotation of GRCm38

  11532 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7825  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: transcription factor MafK
Gene Tree: Maff

Human
homologs
Human Homolog MAFF, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NCBI Gene ID 23764
neXtProt AC  NX_Q9ULX9
Human Synonyms  hMafF, U-MAF
Human Chr (Location)  22q13.1; chr22:38201932-38216511 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Radiation induced(1) Targeted(5)
Genomic Mutations involving Maff (1)
 
Homozygous null mice are viable and fertile and show no obvious functional deficiencies.
 
Interactions
Maff interacts with 151 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process in utero embryonic development, regulation of epidermal cell differentiation, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (179)    Tissues (172)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 125
In situ reporter (knock in) 25
RT-PCR 29
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(23) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000042622 (Evidence)
Entrez Gene17133 (Evidence)
UniGene86646
DFCITC1583975
DoTSDT.101124216, DT.110787444, DT.55217608
NIA Mouse Gene IndexU139783
Consensus CDS ProjectCCDS27638.1
International Mouse Knockout Project StatusMaff
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042622 Ensembl Gene Model | MGI Sequence Detail 11532 C57BL/6J ±  kb
transcript ENSMUST00000096350 Ensembl | MGI Sequence Detail 1933 Not Applicable 
polypeptide ENSMUSP00000094076 Ensembl | MGI Sequence Detail 156 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(12) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR004826 Basic leucine zipper domain, Maf-type
InterPro IPR008917 Eukaryotic transcription factor, Skn-1-like, DNA-binding
InterPro IPR024874 Transcription factor Maf
Protein Ontology PR:000010049 transcription factor MafF
References
(Earliest) J:16848 Igarashi K, et al., Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins [see comments]. Nature. 1994 Feb 10;367(6463):568-72
(Latest) J:214095 Osipovich AB, et al., Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Development. 2014 Aug;141(15):2939-49
All references(42)
Other
accession IDs
MGD-MRK-12102

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory