About   Help   FAQ
Maf Gene Detail
Summary
  • Symbol
    Maf
  • Name
    avian musculoaponeurotic fibrosarcoma oncogene homolog
  • Synonyms
    2810401A20Rik, A230108G15Rik, c-maf
  • Feature Type
    protein coding gene
  • IDs
    MGI:96909
    NCBI Gene: 17132
  • Gene Overview
    MyGene.info: MAF
  • Alliance
  • Transcription Start Sites
    35 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:115703253-115706894 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 62.61 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    22 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96909
protein coding gene Chr8:115682942-115707794 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034162
protein coding gene Chr8:118728440-118755365 (-)
A/J MGP_AJ_G0034142
protein coding gene Chr8:113902743-113928460 (-)
AKR/J MGP_AKRJ_G0034069
protein coding gene Chr8:117214010-117240387 (-)
BALB/cJ MGP_BALBcJ_G0034136
protein coding gene Chr8:114086923-114111765 (-)
C3H/HeJ MGP_C3HHeJ_G0033847
protein coding gene Chr8:117934462-117959307 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034656
protein coding gene Chr8:122752795-122777709 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031598
protein coding gene Chr8:106893426-106899779 (-)
CAST/EiJ MGP_CASTEiJ_G0033174
protein coding gene Chr8:117689596-117714436 (-)
CBA/J MGP_CBAJ_G0033820
protein coding gene Chr8:127126990-127157612 (-)
DBA/2J MGP_DBA2J_G0033976
protein coding gene Chr8:113126905-113151740 (-)
FVB/NJ MGP_FVBNJ_G0033919
protein coding gene Chr8:112111901-112136745 (-)
LP/J MGP_LPJ_G0034065
protein coding gene Chr8:118863990-118889516 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033966
protein coding gene Chr8:129811982-129838230 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034674
protein coding gene Chr8:117279153-117303947 (-)
PWK/PhJ MGP_PWKPhJ_G0032876
protein coding gene Chr8:112817178-112842765 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032716
protein coding gene Chr8:115939053-115967642 (-)
WSB/EiJ MGP_WSBEiJ_G0033290
protein coding gene Chr8:117988259-118014145 (-)



Homology
more
  • Human Ortholog
    MAF, MAF bZIP transcription factor
  • Vertebrate Orthologs
    5
  • Human Ortholog
    MAF, MAF bZIP transcription factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AYGRP, CCA4, c-MAF, CTRCT21
  • Links
    NCBI Gene ID: 4094
    neXtProt AC: NX_O75444
    UniProt: O75444

  • Chr Location
    16q23.2; chr16:79202624-79600725 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Maf mouse models; 1 with human MAF associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 9 alleles in 8 genetic backgrounds
    1 phenotype from multigenic genotypes
    2 images
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes show increased mortality at embryonic day 17.5-18.5, low postnatal survival, abnormal differentiation of lens fiber cells causing microphthalmia, defective lens development and impaired IL4 production by CD4+ T cells and natural killer cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17132 NCBI Gene Model | MGI Sequence Detail 3642 C57BL/6J ±  kb
    transcript NM_001025577 RefSeq | MGI Sequence Detail 3642 Not Specified  
    polypeptide P54843 UniProt | EBI | MGI Sequence Detail 370 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 22
      Primer pair 5
      Other 2

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-12101, MGI:1925586, MGI:2142746, MGI:2444997
    References
    more
    • Summaries
      All 148
      Developmental Gene Expression 66
      Diseases 2
      Gene Ontology 16
      Phenotypes 33
    • Earliest
      J:14384 Copeland NG, et al., A genetic linkage map of the mouse: current applications and future prospects [see comments]. Science. 1993 Oct 1;262(5130):57-66
    • Latest
      J:265317 Chihara N, et al., Induction and transcriptional regulation of the co-inhibitory gene module in T cells. Nature. 2018 Jun;558(7710):454-459

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory