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Maf Gene Detail
Summary
  • Symbol
    Maf
  • Name
    avian musculoaponeurotic fibrosarcoma oncogene homolog
  • Synonyms
    2810401A20Rik, A230108G15Rik, c-maf
  • Feature Type
    protein coding gene
  • IDs
    MGI:96909
    NCBI Gene: 17132
  • Gene Overview
    MyGene.info: MAF
Location & Maps
more
  • Sequence Map
    Chr8:115682942-115707794 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24853 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MAF, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
  • Vertebrate Orthologs
    5
  • Human Ortholog
    MAF, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
    Orthology source: HomoloGene
  • Synonyms
    AYGRP, CCA4, c-MAF, CTRCT21
  • Links
    NCBI Gene ID: 4094
    neXtProt AC: NX_O75444

  • Chr Location
    16q22-q23; chr16:79212772-79600786 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Maf mouse models; 2 with human MAF associations

Human Disease Mouse Models
       Cataract 21, Multiple Types; CTRCT21   OMIM: 610202 View 1 model
       Myeloma, Multiple   OMIM: 254500 View 2 models
       Ayme-Gripp Syndrome; AYGRP   OMIM: 601088
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 9 alleles in 8 genetic backgrounds
    1 phenotype from multigenic genotypes
    2 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (ENU)
    1
  • Radiation induced
    1
  • Targeted
    5
  • Transgenic
    3
  • Incidental Mutations
Homozygotes show increased mortality at embryonic day 17.5-18.5, low postnatal survival, abnormal differentiation of lens fiber cells causing microphthalmia, defective lens development and impaired IL4 production by CD4+ T cells and natural killer cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024922 VEGA Gene Model | MGI Sequence Detail 24853 C57BL/6J ±  kb
transcript OTTMUST00000061393 VEGA | MGI Sequence Detail 3223 Not Applicable  
polypeptide OTTMUSP00000030104 VEGA | MGI Sequence Detail 380 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    201 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000010045 transcription factor Maf
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR004826 Basic leucine zipper domain, Maf-type
    IPR013592 Maf transcription factor, N-terminal
    IPR024874 Transcription factor Maf
    IPR028573 Transcription factor MafF
    IPR008917 Transcription factor, Skn-1-like, DNA-binding domain
Molecular
Reagents
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  • All nucleic 25
    cDNA 19
    Primer pair 4
    Other 2

    Microarray probesets 9
Other
Accession IDs
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MGD-MRK-12101, MGI:1925586, MGI:2142746, MGI:2444997
References
more
  • Summaries
    All 118
    Developmental Gene Expression 58
    Diseases 2
    Gene Ontology 15
    Phenotypes 30
  • Earliest
    J:14384 Copeland NG, et al., A genetic linkage map of the mouse: current applications and future prospects [see comments]. Science. 1993 Oct 1;262(5130):57-66
  • Latest
    J:225832 Giordano M, et al., Molecular profiling of CD8 T cells in autochthonous melanoma identifies Maf as driver of exhaustion. EMBO J. 2015 Aug 4;34(15):2042-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory