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Maf
Gene Detail
Symbol

Name
ID
Maf
avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog
MGI:96909
Synonyms
2810401A20Rik, A230108G15Rik, c-maf
Feature Type
protein coding gene
Genetic Map
Chromosome 8
62.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr8:115682942-115707794 bp, - strand
From VEGA annotation of GRCm38

  24853 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74552  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle

HCOP human homology predictions: MAF
Protein SuperFamily: maf transforming protein
Gene Tree: Maf

Human
homologs
MAF, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4094
neXtProt AC: NX_O75444

Human Synonyms: AYGRP, CCA4, c-MAF, CTRCT21

Human Chr (Location): 16q22-q23; chr16:79212772-79600786 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human MAF

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Radiation induced(1) Targeted(5) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes show increased mortality at embryonic day 17.5-18.5, low postnatal survival, abnormal differentiation of lens fiber cells causing microphthalmia, defective lens development and impaired IL4 production by CD4+ T cells and natural killer cells.
 
Human Diseases Modeled in Mice Using Maf (2)    Mutations Annotated to Human Diseases (3)    Phenotype Images(2)
Interactions
Maf interacts with 402 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cell development, cytokine production, ...
Component cytoplasm, nucleus
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (56 records)
Data Summary: Results (217)    Tissues (86)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 196
In situ reporter (knock in) 10
RT-PCR 8
cDNA source data(18)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: GEISHA MAF ; Xenbase maf ; ZFIN maf    NEW 
Molecular
reagents
All nucleic(25) cDNA(19) Primer pair(4) Other(2)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000024922 (Evidence)
Ensembl Gene Model ENSMUSG00000055435 (Evidence)
Entrez Gene 17132 (Evidence)
DFCI TC1585697, TC1598781, TC1613873, TC1652786
DoTS DT.101227673, DT.110899502, DT.40169651, DT.523436, DT.55239338, DT.87068516, DT.91332630
NIA Mouse Gene Index U252694
Consensus CDS Project CCDS40486.1
International Mouse Phenotyping Consortium Status Maf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024922 VEGA Gene Model | MGI Sequence Detail 24853 C57BL/6J ±  kb
transcript OTTMUST00000061393 VEGA | MGI Sequence Detail 3223 Not Applicable 
polypeptide OTTMUSP00000030104 VEGA | MGI Sequence Detail 380 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(202 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR004826 Basic leucine zipper domain, Maf-type
InterPro IPR008917 Eukaryotic transcription factor, Skn-1-like, DNA-binding
InterPro IPR013592 Maf transcription factor, N-terminal
InterPro IPR024874 Transcription factor Maf
Protein Ontology PR:000010045 transcription factor Maf
References
(Earliest) J:14384 Copeland NG, et al., A genetic linkage map of the mouse: current applications and future prospects [see comments]. Science. 1993 Oct 1;262(5130):57-66
(Latest) J:214014 Vogt D, et al., Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position. Neuron. 2014 Apr 16;82(2):350-64
All references(118)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-12101, MGI:1925586, MGI:2142746, MGI:2444997

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory