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Maf
Gene Detail
Symbol

Name
ID
Maf
avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog
MGI:96909
Synonyms
2810401A20Rik, A230108G15Rik, c-maf
Feature Type
protein coding gene
Genetic Map
Chromosome 8
62.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr8:115682942-115707794 bp, - strand
From VEGA annotation of GRCm38

  24853 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74552  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle

Protein SuperFamily: maf transforming protein
Gene Tree: Maf

Human
homologs
Human Homolog MAF, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
NCBI Gene ID 4094
neXtProt AC  NX_O75444
Human Synonyms  CCA4, c-MAF
Human Chr (Location)  16q22-q23; chr16:79593848-79600725 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MAF
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Radiation induced(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes show increased mortality at embryonic day 17.5-18.5, low postnatal survival, abnormal differentiation of lens fiber cells causing microphthalmia, defective lens development and impaired IL4 production by CD4+ T cells and natural killer cells.
 
Human Diseases Modeled Using Mouse Maf (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Maf interacts with 402 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cell development, cytokine production, ...
Component cytoplasm, nucleus
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (54 records)
Data Summary: Results (217)    Tissues (86)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 196
In situ reporter (knock in) 10
RT-PCR 8
cDNA source data(18)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(25) cDNA(19) Primer pair(4) Other(2)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000024922 (Evidence)
Ensembl Gene ModelENSMUSG00000055435 (Evidence)
Entrez Gene17132 (Evidence)
DFCITC1585697, TC1598781, TC1613873, TC1652786
DoTSDT.101227673, DT.110899502, DT.40169651, DT.523436, DT.55239338, DT.87068516, DT.91332630
NIA Mouse Gene IndexU252694
Consensus CDS ProjectCCDS40486.1
International Mouse Knockout Project StatusMaf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024922 VEGA Gene Model | MGI Sequence Detail 24853 C57BL/6J ±  kb
transcript OTTMUST00000061393 VEGA | MGI Sequence Detail 3223 Not Applicable 
polypeptide OTTMUSP00000030104 VEGA | MGI Sequence Detail 380 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(202 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR004826 Basic leucine zipper domain, Maf-type
InterPro IPR008917 Eukaryotic transcription factor, Skn-1-like, DNA-binding
InterPro IPR013592 Maf transcription factor, N-terminal
InterPro IPR024874 Transcription factor Maf
Protein Ontology PR:000010045 transcription factor Maf
References
(Earliest) J:14384 Copeland NG, et al., A genetic linkage map of the mouse: current applications and future prospects [see comments]. Science. 1993 Oct 1;262(5130):57-66
(Latest) J:207861 Manthey AL, et al., Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development. Mech Dev. 2014 Feb;131:86-110
All references(118)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12101, MGI:1925586, MGI:2142746, MGI:2444997

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory