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Mxd1
Gene Detail
 Symbol
Name
ID
Mxd1
MAX dimerization protein 1
MGI:96908
Synonyms Mad, Mad1
Feature Type protein coding gene
Genetic Map
Chromosome 6
37.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr6:86647044-86669159 bp, - strand
From NCBI annotation of GRCm38

  22116 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1767  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: MAX interacting protein
Gene Tree: Mxd1

Human
homologs
Human Homolog MXD1, MAX dimerization protein 1
NCBI Gene ID 4084
neXtProt AC  NX_Q05195
Human Synonyms  BHLHC58, MAD, MAD1
Human Chr (Location)  2p13-p12; chr2:69915041-69942945 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Mice homozygous for a knock-out allele exhibit altered myelopoiesis, increased proliferative potential of bone marrow granulocytic precursors, increased sensitivity of myeloid cells to apoptosis-inducing stimuli, and inhibited cell cycle withdrawal during a late stage of granulocyte differentiation.
 
Interactions
Mxd1 interacts with 405 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process negative regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-templated, ...
Component nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (156)    Tissues (154)    Images (19)
Theiler Stages: 2, 3, 4, 5, 17, 21, 22, 23, 27, 28
Assay TypeResults
RNA in situ 148
RT-PCR 8
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(21) Primer pair(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000001156 (Evidence)
Entrez Gene17119 (Evidence)
DFCITC1581106, TC1598219
DoTSDT.110490982, DT.91335637
NIA Mouse Gene IndexU027570
Consensus CDS ProjectCCDS51835.1
International Mouse Knockout Project StatusMxd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17119 NCBI Gene Model | MGI Sequence Detail 22116 C57BL/6J ±  kb
transcript NM_010751 RefSeq | MGI Sequence Detail 4662 C57BL/6 
polypeptide P50538 UniProt | EBI | MGI Sequence Detail 227 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(4) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(103 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000010790 max dimerization protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:19396 Ayer DE, et al., Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell. 1993 Jan 29;72(2):211-22
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(50)
Other
accession IDs
MGD-MRK-12100, MGI:2141648

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory