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Mxd1
Gene Detail
Symbol

Name
ID
Mxd1
MAX dimerization protein 1
MGI:96908
Synonyms
Mad, Mad1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
37.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr6:86647044-86669159 bp, - strand
From Ensembl annotation of GRCm38

  22116 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1767  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: MXD1
Protein SuperFamily: MAX interacting protein
Gene Tree: Mxd1

Human
homologs
MXD1, MAX dimerization protein 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4084
neXtProt AC: NX_Q05195

Human Synonyms: BHLHC58, MAD, MAD1

Human Chr (Location): 2p13-p12; chr2:69915041-69942945 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Spontaneous(1) Targeted(3)
Genomic Mutations involving Mxd1 (1)
 
Mice homozygous for a knock-out allele exhibit altered myelopoiesis, increased proliferative potential of bone marrow granulocytic precursors, increased sensitivity of myeloid cells to apoptosis-inducing stimuli, and inhibited cell cycle withdrawal during a late stage of granulocyte differentiation.
 
Interactions
Mxd1 interacts with 404 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process negative regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-templated, ...
Component nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (156)    Tissues (154)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 148
RT-PCR 8
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MXD1 ; Xenbase mxd1    NEW 
Molecular
reagents
All nucleic(23) cDNA(21) Primer pair(2)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000001156 (Evidence)
Entrez Gene 17119 (Evidence)
DFCI TC1581106, TC1598219
DoTS DT.110490982, DT.91335637
NIA Mouse Gene Index U027570
Consensus CDS Project CCDS51835.1
International Mouse Phenotyping Consortium Status Mxd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001156 Ensembl Gene Model | MGI Sequence Detail 22116 C57BL/6J ±  kb
transcript ENSMUST00000001184 Ensembl | MGI Sequence Detail 4662 Not Applicable 
polypeptide ENSMUSP00000001184 Ensembl | MGI Sequence Detail 227 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(103 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000010790 max dimerization protein 1
References
(Earliest) J:19396 Ayer DE, et al., Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell. 1993 Jan 29;72(2):211-22
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(48)
Other
accession IDs
MGD-MRK-12100, MGI:2141648

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory