M6pr
Gene Detail

Symbol Name ID

M6pr mannose-6-phosphate receptor, cation dependent MGI:96904

Synonyms

CD-MPR, Mpr46

Feature Type

protein coding gene

Genetic Map

Chromosome 6

57.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr6:122308720-122317680 bp, + strand From VEGA annotation of GRCm38   8961 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31086  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: mannose 6-phosphate receptor, cation-dependent
Gene Tree: M6pr

Human homologs

Human Homolog		M6PR, mannose-6-phosphate receptor (cation dependent)
NCBI Gene ID		4074
neXtProt AC		NX_P20645
Human Synonyms		CD-MPR, MPR46, MPR 46, MPR-46, SMPR
Human Chr (Location)		12p13; chr12:9092957-9102357 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(30) : Targeted(4) Gene trapped(26)
 

Mice homozygous for disruptions in this gene are fertile and display no visible phenotypic abnormalities; however, serum levels of lysosomal enzymes are elevated.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	intracellular protein transport, mannose transport, ...
Component	cell surface, endosome, ...
Function	mannose binding, mannose transmembrane transporter activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (46)    Tissues (21)    Images (2)
Theiler Stages: 18, 20, 21, 22, 23, 24

Assay Type	Results
RNA in situ	24
RNase protection	22

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) Genomic(4) cDNA(20)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000023879 (Evidence)
Ensembl Gene Model	ENSMUSG00000007458 (Evidence)
Entrez Gene	17113 (Evidence)
DoTS	DT.101390862, DT.110499321, DT.494788, DT.94409035
Consensus CDS Project	CCDS20493.1
International Mouse Knockout Project Status	M6pr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023879	VEGA Gene Model | MGI Sequence Detail	8961	C57BL/6J
transcript	OTTMUST00000058335	VEGA | MGI Sequence Detail	2515	Not Applicable
polypeptide	OTTMUSP00000028254	VEGA | MGI Sequence Detail	278	Not Applicable

All sequences(52) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(47 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000296	Cation-dependent mannose-6-phosphate receptor
InterPro	IPR009011	Mannose-6-phosphate receptor binding domain
Protein Ontology	PR:000010032	cation-dependent mannose-6-phosphate receptor

References

(Earliest) J:11205 Ma ZM, et al., Cloning, sequencing, and functional characterization of the murine 46-kDa mannose 6-phosphate receptor. J Biol Chem. 1991 Jun 5;266(16):10589-95
(Latest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
All references(55)

Other accession IDs

MGD-MRK-12091