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M6pr
Gene Detail
Symbol

Name
ID
M6pr
mannose-6-phosphate receptor, cation dependent
MGI:96904
Synonyms
CD-MPR, Mpr46
Feature Type
protein coding gene
Genetic Map
Chromosome 6
57.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:122308720-122317680 bp, + strand
From VEGA annotation of GRCm38

  8961 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31086  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: mannose 6-phosphate receptor, cation-dependent
Gene Tree: M6pr

Human
homologs
Human Homolog M6PR, mannose-6-phosphate receptor (cation dependent)
NCBI Gene ID 4074
neXtProt AC  NX_P20645
Human Synonyms  CD-MPR, MPR46, MPR 46, MPR-46, SMPR
Human Chr (Location)  12p13; chr12:8940361-8949761 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(26) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene are fertile and display no visible phenotypic abnormalities; however, serum levels of lysosomal enzymes are elevated.
 
Interactions
M6pr interacts with 210 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process intracellular protein transport, mannose transport, ...
Component cell, endosome, ...
Function mannose binding, mannose transmembrane transporter activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (46)    Tissues (21)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
RNase protection 22
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) Genomic(4) cDNA(20)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000023879 (Evidence)
Ensembl Gene ModelENSMUSG00000007458 (Evidence)
Entrez Gene17113 (Evidence)
DoTSDT.101390862, DT.110499321, DT.494788, DT.94409035
Consensus CDS ProjectCCDS20493.1
International Mouse Knockout Project StatusM6pr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023879 VEGA Gene Model | MGI Sequence Detail 8961 C57BL/6J ±  kb
transcript OTTMUST00000058335 VEGA | MGI Sequence Detail 2515 Not Applicable 
polypeptide OTTMUSP00000028254 VEGA | MGI Sequence Detail 278 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(56 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000296 Cation-dependent mannose-6-phosphate receptor
InterPro IPR009011 Mannose-6-phosphate receptor binding domain
Protein Ontology PR:000010032 cation-dependent mannose-6-phosphate receptor
References
(Earliest) J:11205 Ma ZM, et al., Cloning, sequencing, and functional characterization of the murine 46-kDa mannose 6-phosphate receptor. J Biol Chem. 1991 Jun 5;266(16):10589-95
(Latest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
All references(55)
Other
accession IDs
MGD-MRK-12091

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory