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Lyz1
Gene Detail
Symbol

Name
ID
Lyz1
lysozyme 1
MGI:96902
Synonyms
Lyz, Lzp-s, renal amyloidosis
Feature Type
protein coding gene
Genetic Map
Chromosome 10
65.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:117287796-117292868 bp, - strand
From Ensembl annotation of GRCm38

  5073 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:121490  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: LYZ
Gene Tree: Lyz1

Human
homologs
LYZ, lysozyme
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4069
neXtProt AC: NX_P61626

Human Synonyms: LZM

Human Chr (Location): 12q15; chr12:69348354-69354233 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LYZ

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(1) Transgenic(3)
Incidental mutations (data from Mutagenetix , APF )
 
This locus controls heat stability of lysozyme P. The d allele determines low heat stability in C3H/He; the c allele determines high heat stability in CASA. Another variation, measured as electrophoretic mobility, is seen between BALB/c and M. spretus.
 
Interactions
Lyz1 interacts with 122 markers (Mir17, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cytolysis, defense response to bacterium, ...
Component cytoplasm, endoplasmic reticulum lumen, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (50)    Tissues (4)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 48
RT-PCR 2
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lyz    NEW 
Molecular
reagents
All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000069515 (Evidence)
Entrez Gene 17110 (Evidence)
UniGene 177539
NIA Mouse Gene Index U032255
EC 3.2.1.17
Consensus CDS Project CCDS48695.1
International Mouse Phenotyping Consortium Status Lyz1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000069515 Ensembl Gene Model | MGI Sequence Detail 5073 C57BL/6J ±  kb
transcript ENSMUST00000092162 Ensembl | MGI Sequence Detail 1264 Not Applicable 
polypeptide ENSMUSP00000089800 Ensembl | MGI Sequence Detail 148 Not Applicable 

For the selected sequences
All sequences(14) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(107 from dbSNP Build 137)    SNPs within 2kb including multiple locations(133)
Protein-related
information
ResourceIDDescription
InterPro IPR001916 Glycoside hydrolase, family 22
InterPro IPR019799 Glycoside hydrolase, family 22, conserved site
InterPro IPR000974 Glycoside hydrolase, family 22, lysozyme
InterPro IPR023346 Lysozyme-like domain
Protein Ontology PR:000010029 lysozyme C-1
References
(Earliest) J:8670 Hammer MF, et al., Regulatory and structural genes for lysozymes of mice. Genetics. 1987 Mar;115(3):521-33
(Latest) J:215917 Yu S, et al., TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis. EMBO J. 2014 Sep 1;33(17):1882-95
All references(35)
Other
accession IDs
MGD-MRK-12088

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory