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Lyz1 Gene Detail
Summary
  • Symbol
    Lyz1
  • Name
    lysozyme 1
  • Synonyms
    Lyz, Lzp-s, renal amyloidosis
  • Feature Type
    protein coding gene
  • IDs
    MGI:96902
    NCBI Gene: 17110
  • Gene Overview
    MyGene.info: LYZ
Location & Maps
more
  • Sequence Map
    Chr10:117287796-117292868 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5073 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 65.35 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    LYZ, lysozyme
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LYZ, lysozyme
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LYZF1, LZM
  • Links
    NCBI Gene ID: 4069
    neXtProt AC: NX_P61626

  • Chr Location
    12q15; chr12:69348354-69354233 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 121490
    1 human;2 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: LYZ
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human LYZ associations

Human Disease Mouse Models
       Amyloidosis, Familial Visceral   OMIM: 105200
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from multigenic genotypes
    99 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    1
  • Transgenic
    4
  • Genomic Mutations
    1 involving Lyz1
  • Incidental Mutations
This locus controls heat stability of lysozyme P. The d allele determines low heat stability in C3H/He; the c allele determines high heat stability in CASA. Another variation, measured as electrophoretic mobility, is seen between BALB/c and M. spretus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000069515 Ensembl Gene Model | MGI Sequence Detail 5073 C57BL/6J ±  kb
transcript ENSMUST00000092162 Ensembl | MGI Sequence Detail 1264 Not Applicable  
polypeptide ENSMUSP00000089800 Ensembl | MGI Sequence Detail 148 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    95 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-12088
References
more
  • Summaries
    All 34
    Developmental Gene Expression 12
    Gene Ontology 4
    Phenotypes 99
  • Earliest
    J:8670 Hammer MF, et al., Regulatory and structural genes for lysozymes of mice. Genetics. 1987 Mar;115(3):521-33
  • Latest
    J:224084 Elliott EN, et al., Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium. Development. 2015 Jun 15;142(12):2163-72

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory