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Lyz1
Gene Detail
 Symbol
Name
ID
Lyz1
lysozyme 1
MGI:96902
Synonyms Lyz, Lzp-s, renal amyloidosis
Feature Type protein coding gene
Genetic Map
Chromosome 10
65.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:117287796-117292868 bp, - strand
From Ensembl annotation of GRCm38

  5073 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:121490  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Lyz1

Human
homologs
Human Homolog LYZ, lysozyme
NCBI Gene ID 4069
neXtProt AC  NX_P61626
Human Synonyms  LZM
Human Chr (Location)  12q15; chr12:69348354-69354233 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LYZ
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
This locus controls heat stability of lysozyme P. The d allele determines low heat stability in C3H/He; the c allele determines high heat stability in CASA. Another variation, measured as electrophoretic mobility, is seen between BALB/c and M. spretus.
 
Interactions
Lyz1 interacts with 122 markers (Mir17, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cell wall macromolecule catabolic process, cytolysis, ...
Component cytoplasm, endoplasmic reticulum lumen, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (50)    Tissues (4)    Images (25)
Theiler Stages: 23, 26
Assay TypeResults
RNA in situ 48
RT-PCR 2
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000069515 (Evidence)
Entrez Gene17110 (Evidence)
UniGene177539
NIA Mouse Gene IndexU032255
EC3.2.1.17
Consensus CDS ProjectCCDS48695.1
International Mouse Knockout Project StatusLyz1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000069515 Ensembl Gene Model | MGI Sequence Detail 5073 C57BL/6J ±  kb
transcript ENSMUST00000092162 Ensembl | MGI Sequence Detail 1264 Not Applicable 
polypeptide ENSMUSP00000089800 Ensembl | MGI Sequence Detail 148 Not Applicable 

For the selected sequences
All sequences(13) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(107 from dbSNP Build 137)    SNPs within 2kb including multiple locations(133)
Protein-related
information
ResourceIDDescription
InterPro IPR001916 Glycoside hydrolase, family 22
InterPro IPR019799 Glycoside hydrolase, family 22, conserved site
InterPro IPR000974 Glycoside hydrolase, family 22, lysozyme
InterPro IPR023346 Lysozyme-like domain
Protein Ontology PR:000010029 lysozyme C-1
References (Earliest) J:8670 Hammer MF, et al., Regulatory and structural genes for lysozymes of mice. Genetics. 1987 Mar;115(3):521-33
(Latest) J:184887 Du A, et al., Arx is required for normal enteroendocrine cell development in mice and humans. Dev Biol. 2012 May 1;365(1):175-88
All references(34)
Other
accession IDs
MGD-MRK-12088

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory