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Lyz1 Gene Detail
Summary
  • Symbol
    Lyz1
  • Name
    lysozyme 1
  • Synonyms
    Lyz, Lzp-s, renal amyloidosis
  • Feature Type
    protein coding gene
  • IDs
    MGI:96902
    NCBI Gene: 17110
  • Gene Overview
    MyGene.info: LYZ
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:117287797-117292868 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 65.35 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    95 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96902
protein coding gene Chr10:117287795-117292868 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017758
protein coding gene Chr10:120182175-120188244 (-)
A/J MGP_AJ_G0017734
protein coding gene Chr10:115481562-115487232 (-)
AKR/J MGP_AKRJ_G0017696
protein coding gene Chr10:118876344-118882036 (-)
BALB/cJ MGP_BALBcJ_G0017697
protein coding gene Chr10:115896270-115901346 (-)
C3H/HeJ MGP_C3HHeJ_G0017522
protein coding gene Chr10:119113001-119117611 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0015833
protein coding gene Chr10:110057791-110062598 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0017491
protein coding gene Chr10:129225645-129230092 (-)
DBA/2J MGP_DBA2J_G0017596
protein coding gene Chr10:114644655-114655731 (-)
FVB/NJ MGP_FVBNJ_G0017591
protein coding gene Chr10:113598609-113603827 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0017620
protein coding gene Chr10:132077852-132085962 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018192
protein coding gene Chr10:118926170-118930636 (-)
PWK/PhJ MGP_PWKPhJ_G0016865
protein coding gene Chr10:114715019-114720959 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016655
protein coding gene Chr10:117702179-117715313 (-)
WSB/EiJ MGP_WSBEiJ_G0017144
protein coding gene Chr10:119109953-119126437 (-)



Homology
more
  • Human Ortholog
    LYZ, lysozyme
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LYZ, lysozyme
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LYZF1, LZM
  • Links
    NCBI Gene ID: 4069
    neXtProt AC: NX_P61626
    UniProt: P61626

  • Chr Location
    12q15; chr12:69348354-69354233 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 121490
    1 human;2 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LYZ
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human LYZ associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from multigenic genotypes
    116 phenotype references
This locus controls heat stability of lysozyme P. The d allele determines low heat stability in C3H/He; the c allele determines high heat stability in CASA. Another variation, measured as electrophoretic mobility, is seen between BALB/c and M. spretus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000069515 Ensembl Gene Model | MGI Sequence Detail 5072 C57BL/6J ±  kb
transcript ENSMUST00000092162 Ensembl | MGI Sequence Detail 1263 Not Applicable  
polypeptide ENSMUSP00000089800 Ensembl | MGI Sequence Detail 148 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 15
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-12088
References
more
  • Summaries
    All 167
    Developmental Gene Expression 23
    Gene Ontology 6
    Phenotypes 116
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:274635 Tan C, et al., Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery. J Immunol. 2019 May 15;202(10):2907-2923

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
07/16/2019
MGI 6.14
The Jackson Laboratory