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Lyz2
Gene Detail
Symbol

Name
ID
Lyz2
lysozyme 2
MGI:96897
Synonyms
Lys, Lysm, Lyzs, Lzm, Lzm-s1, Lzp
Feature Type
protein coding gene
Genetic Map
Chromosome 10
65.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr10:117277541-117282272 bp, - strand
From NCBI annotation of GRCm38

  4732 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:121490  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: LYZ
Gene Tree: Lyz2

Human
homologs
LYZ, lysozyme
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4069
neXtProt AC: NX_P61626

Human Synonyms: LZM

Human Chr (Location): 12q15; chr12:69348354-69354233 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LYZ

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(5) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a reporter allele exhibit increased inflammation in response to Micrococcus luteus and its peptidoglycan, despite partial compensatory expression of lysozyme P in macrophages.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Lyz2 interacts with 101 markers (Mir17, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cytolysis, defense response to bacterium, ...
Component cytoplasm, endoplasmic reticulum lumen, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (10)    Tissues (3)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
Northern blot 8
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000069516 (Evidence)
Entrez Gene 17105 (Evidence)
NIA Mouse Gene Index U032254, U353589
EC 3.2.1.17
PDB 1IVM
Consensus CDS Project CCDS48694.1
International Mouse Phenotyping Consortium Status Lyz2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17105 NCBI Gene Model | MGI Sequence Detail 4732 C57BL/6J ±  kb
transcript NM_017372 RefSeq | MGI Sequence Detail 1057 C57BL/6 
polypeptide P08905 UniProt | EBI | MGI Sequence Detail 148 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(121 from dbSNP Build 137)    SNPs within 2kb including multiple locations(145)
Protein-related
information
ResourceIDDescription
InterPro IPR001916 Glycoside hydrolase, family 22
InterPro IPR019799 Glycoside hydrolase, family 22, conserved site
InterPro IPR000974 Glycoside hydrolase, family 22, lysozyme
InterPro IPR030056 Lysozyme C
InterPro IPR023346 Lysozyme-like domain
Protein Ontology PR:000010030 lysozyme C-2
Graphical View of Protein Domain Structure
References
(Earliest) J:8670 Hammer MF, et al., Regulatory and structural genes for lysozymes of mice. Genetics. 1987 Mar;115(3):521-33
(Latest) J:223291 Curtis AM, et al., Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7231-6
All references(714)
Other
accession IDs
MGD-MRK-12083, MGD-MRK-12085, MGI:2143581, MGI:96899

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory