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Lyz2 Gene Detail
Summary
  • Symbol
    Lyz2
  • Name
    lysozyme 2
  • Synonyms
    Lys, Lysm, Lyzs, Lzm, Lzm-s1, Lzp
  • Feature Type
    protein coding gene
  • IDs
    MGI:96897
    NCBI Gene: 17105
  • Gene Overview
    MyGene.info: LYZ
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:117277541-117282272 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 65.34 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96897
protein coding gene Chr10:117277331-117282321 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017757
protein coding gene Chr10:120164478-120186569 (-)
A/J MGP_AJ_G0017733
protein coding gene Chr10:115481562-115487121 (-)
AKR/J MGP_AKRJ_G0017695
protein coding gene Chr10:118855540-118860584 (-)
BALB/cJ MGP_BALBcJ_G0017696
protein coding gene Chr10:115878197-115883811 (-)
C3H/HeJ MGP_C3HHeJ_G0017521
protein coding gene Chr10:119100069-119115936 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0015831
protein coding gene Chr10:110047620-110052290 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0017490
protein coding gene Chr10:129225645-129227199 (-)
DBA/2J MGP_DBA2J_G0017595
protein coding gene Chr10:114627898-114634914 (-)
FVB/NJ MGP_FVBNJ_G0017590
protein coding gene Chr10:113585818-113590041 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0017619
protein coding gene Chr10:132053455-132060195 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018191
protein coding gene Chr10:118926170-118932954 (-)
PWK/PhJ MGP_PWKPhJ_G0016864
protein coding gene Chr10:114715019-114720961 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016654
protein coding gene Chr10:117702179-117705892 (-)
WSB/EiJ MGP_WSBEiJ_G0017143
protein coding gene Chr10:119109953-119114333 (-)



Homology
more
  • Human Ortholog
    LYZ, lysozyme
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LYZ, lysozyme
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LYZF1, LZM
  • Links
    NCBI Gene ID: 4069
    neXtProt AC: NX_P61626
    UniProt: P61626

  • Chr Location
    12q15; chr12:69348354-69354233 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 121490
    1 human;2 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LYZ
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human LYZ associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 2 genetic backgrounds
    383 phenotypes from multigenic genotypes
    2 images
    1216 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele exhibit increased inflammation in response to Micrococcus luteus and its peptidoglycan, despite partial compensatory expression of lysozyme P in macrophages.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17105 NCBI Gene Model | MGI Sequence Detail 4732 C57BL/6J ±  kb
    transcript NM_017372 RefSeq | MGI Sequence Detail 1057 C57BL/6  
    polypeptide P08905 UniProt | EBI | MGI Sequence Detail 148 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 16
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12083, MGD-MRK-12085, MGI:2143581, MGI:96899
    References
    more
    • Summaries
      All 1289
      Developmental Gene Expression 31
      Diseases 4
      Gene Ontology 7
      Phenotypes 1216
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:266036 Divakaruni AS, et al., Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis. Cell Metab. 2018 Sep 4;28(3):490-503.e7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory