Lyz2
Gene Detail

Symbol Name ID

Lyz2 lysozyme 2 MGI:96897

Synonyms

Lys, Lysm, Lyzs, Lzm, Lzm-s1, Lzp

Feature Type

protein coding gene

Genetic Map

Chromosome 10

65.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr10:117277541-117282272 bp, - strand From NCBI annotation of GRCm38   4732 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:124183  Vertebrate Homology Class
2 mouse; 1 rat; 1 cattle; 1 dog

Gene Tree: Lyz2

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a reporter allele exhibit increased inflammation in response to Micrococcus luteus and its peptidoglycan, despite partial compensatory expression of lysozyme P in macrophages.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	cell wall macromolecule catabolic process, cytolysis, ...
Component	cytoplasm, endoplasmic reticulum lumen, ...
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (10)    Tissues (3)    Images (2)
Theiler Stages: 26, 28

Assay Type	Results
Immunohistochemistry	2
Northern blot	8

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000069516 (Evidence)
Entrez Gene	17105 (Evidence)
NIA Mouse Gene Index	U032254, U353589
EC	3.2.1.17
PDB	1IVM
Consensus CDS Project	CCDS48694.1
International Mouse Knockout Project Status	Lyz2

Sequences

Length	Strain/Species
genomic	17105	NCBI Gene Model | MGI Sequence Detail	4732	C57BL/6J
transcript	NM_017372	RefSeq | MGI Sequence Detail	1057	C57BL/6
polypeptide	P08905	UniProt | EBI | MGI Sequence Detail	148	Not Applicable

All sequences(28) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(56 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001916	Glycoside hydrolase, family 22
InterPro	IPR019799	Glycoside hydrolase, family 22, conserved site
InterPro	IPR000974	Glycoside hydrolase, family 22, lysozyme
InterPro	IPR023346	Lysozyme-like domain
Protein Ontology	PR:000010030	lysozyme C-2

Graphical View of Protein Domain Structure

References

(Earliest) J:8670 Hammer MF, et al., Regulatory and structural genes for lysozymes of mice. Genetics. 1987 Mar;115(3):521-33
(Latest) J:195205 Albers J, et al., Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin. J Cell Biol. 2013 Feb 18;200(4):537-49
All references(465)

Other accession IDs

MGD-MRK-12083, MGD-MRK-12085, MGI:2143581, MGI:96899