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Lyz2
Gene Detail
Symbol

Name
ID
Lyz2
lysozyme 2
MGI:96897
Synonyms
Lys, Lysm, Lyzs, Lzm, Lzm-s1, Lzp
Feature Type
protein coding gene
Genetic Map
Chromosome 10
65.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr10:117277541-117282272 bp, - strand
From NCBI annotation of GRCm38

  4732 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:121490  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Lyz2

Human
homologs
Human Homolog LYZ, lysozyme
NCBI Gene ID 4069
neXtProt AC  NX_P61626
Human Synonyms  LZM
Human Chr (Location)  12q15; chr12:69348354-69354233 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LYZ
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter allele exhibit increased inflammation in response to Micrococcus luteus and its peptidoglycan, despite partial compensatory expression of lysozyme P in macrophages.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Lyz2 interacts with 101 markers (Mir17, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cytolysis, defense response to bacterium, ...
Component cytoplasm, endoplasmic reticulum lumen, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (10)    Tissues (3)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
Northern blot 8
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000069516 (Evidence)
Entrez Gene17105 (Evidence)
NIA Mouse Gene IndexU032254, U353589
EC3.2.1.17
PDB1IVM
Consensus CDS ProjectCCDS48694.1
International Mouse Knockout Project StatusLyz2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17105 NCBI Gene Model | MGI Sequence Detail 4732 C57BL/6J ±  kb
transcript NM_017372 RefSeq | MGI Sequence Detail 1057 C57BL/6 
polypeptide P08905 UniProt | EBI | MGI Sequence Detail 148 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(121 from dbSNP Build 137)    SNPs within 2kb including multiple locations(145)
Protein-related
information
ResourceIDDescription
InterPro IPR001916 Glycoside hydrolase, family 22
InterPro IPR019799 Glycoside hydrolase, family 22, conserved site
InterPro IPR000974 Glycoside hydrolase, family 22, lysozyme
InterPro IPR023346 Lysozyme-like domain
Protein Ontology PR:000010030 lysozyme C-2
Graphical View of Protein Domain Structure
References
(Earliest) J:8670 Hammer MF, et al., Regulatory and structural genes for lysozymes of mice. Genetics. 1987 Mar;115(3):521-33
(Latest) J:215205 Festuccia WT, et al., Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide. PLoS One. 2014;9(4):e95432
All references(640)
Other
accession IDs
MGD-MRK-12083, MGD-MRK-12085, MGI:2143581, MGI:96899

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory