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Lyl1 Gene Detail
Summary
  • Symbol
    Lyl1
  • Name
    lymphoblastomic leukemia 1
  • Synonyms
    bHLHa18, Lyl-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96891
    NCBI Gene: 17095
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85428078-85431569 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 41.02 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    34 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96891
protein coding gene Chr8:85428051-85432876 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033868
protein coding gene Chr8:85614232-85617489 (+)
A/J MGP_AJ_G0033851
protein coding gene Chr8:82243916-82247173 (+)
AKR/J MGP_AKRJ_G0033777
protein coding gene Chr8:84677787-84681044 (+)
BALB/cJ MGP_BALBcJ_G0033844
protein coding gene Chr8:82366571-82369828 (+)
C3H/HeJ MGP_C3HHeJ_G0033554
protein coding gene Chr8:85299356-85302613 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034364
protein coding gene Chr8:88906466-88909724 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031306
protein coding gene Chr8:76036562-76039817 (+)
CAST/EiJ MGP_CASTEiJ_G0032884
protein coding gene Chr8:84722456-84725695 (+)
CBA/J MGP_CBAJ_G0033530
protein coding gene Chr8:91949423-91952676 (+)
DBA/2J MGP_DBA2J_G0033683
protein coding gene Chr8:81884808-81888065 (+)
FVB/NJ MGP_FVBNJ_G0033631
protein coding gene Chr8:80822184-80825441 (+)
LP/J MGP_LPJ_G0033775
protein coding gene Chr8:85728589-85731846 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033673
protein coding gene Chr8:94494564-94497821 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034381
protein coding gene Chr8:84667589-84670847 (+)
PWK/PhJ MGP_PWKPhJ_G0032588
protein coding gene Chr8:81127352-81130610 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032424
protein coding gene Chr8:83478645-83481895 (+)
WSB/EiJ MGP_WSBEiJ_G0032997
protein coding gene Chr8:85098366-85101623 (+)



Homology
more
  • Human Ortholog
    LYL1, LYL1 basic helix-loop-helix family member
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LYL1, LYL1 basic helix-loop-helix family member
  • Synonyms
    bHLHa18
  • Links
    NCBI Gene ID: 4066
    neXtProt AC: NX_P12980
    UniProt: P12980

  • Chr Location
    19p13.13; chr19:13099033-13103161 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human LYL1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Radiation induced
    1
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    2 involving Lyl1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice with mutation of this gene are vaible and fertile. Defects in production and differentiation of progenitor cells are observed, along with impaired ability of fetal liver or bone marrow cells in reconstituting B and T lineages after transplant.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034041 Ensembl Gene Model | MGI Sequence Detail 3492 C57BL/6J ±  kb
transcript ENSMUST00000037165 Ensembl | MGI Sequence Detail 1714 Not Applicable  
polypeptide ENSMUSP00000046010 Ensembl | MGI Sequence Detail 278 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    Genomic 5
    cDNA 33

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-12067, MGD-MRK-12068
References
more
  • Summaries
    All 92
    Developmental Gene Expression 9
    Gene Ontology 5
    Phenotypes 50
  • Earliest
    J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
  • Latest
    J:329360 Jones SS, et al., Lyl1-deficiency promotes inflammatory responses and increases mycobacterial burden in response to Mycobacterium tuberculosis infection in mice. Front Immunol. 2022;13:948047

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory