About   Help   FAQ
Lyl1
Gene Detail
Symbol

Name
ID
Lyl1
lymphoblastomic leukemia 1
MGI:96891
Synonyms
bHLHa18, Lyl-1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
41.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr8:84701457-84704715 bp, + strand
From Ensembl annotation of GRCm38

  3259 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4078  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 zebrafish

Gene Tree: Lyl1

Human
homologs
Human Homolog LYL1, lymphoblastic leukemia associated hematopoiesis regulator 1
NCBI Gene ID 4066
neXtProt AC  NX_P12980
Human Synonyms  bHLHa18
Human Chr (Location)  19p13.2; chr19:13097188-13103160 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Mice with mutation of this gene are vaible and fertile. Defects in production and differentiation of progenitor cells are observed, along with impaired ability of fetal liver or bone marrow cells in reconstituting B and T lineages after transplant.
 
Interactions
Lyl1 interacts with 34 markers (Mir30c-1, Mir30c-2, Mir138-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process B cell differentiation, blood vessel maturation, ...
Component nucleus
Function DNA binding, protein dimerization activity
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (75)    Tissues (32)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 75
cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) Genomic(5) cDNA(32)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000034041 (Evidence)
Entrez Gene17095 (Evidence)
UniGene4925
DFCITC1582499
DoTSDT.493032, DT.94326151
NIA Mouse Gene IndexU009573
Consensus CDS ProjectCCDS22476.1
International Mouse Knockout Project StatusLyl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034041 Ensembl Gene Model | MGI Sequence Detail 3259 C57BL/6J ±  kb
transcript ENSMUST00000037165 Ensembl | MGI Sequence Detail 1800 Not Applicable 
polypeptide ENSMUSP00000046010 Ensembl | MGI Sequence Detail 278 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(6) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000010001 protein lyl-1
References
(Earliest) J:47525 Cleary ML, et al., Chromosomal translocation involving the beta T cell receptor gene in acute leukemia. J Exp Med. 1988 Feb 1;167(2):682-7
(Latest) J:210273 Pirot N, et al., Lung endothelial barrier disruption in Lyl1-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2014 Apr 15;306(8):L775-85
All references(49)
Other
accession IDs
MGD-MRK-12067, MGD-MRK-12068

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory