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Lyl1 Gene Detail
Summary
  • Symbol
    Lyl1
  • Name
    lymphoblastomic leukemia 1
  • Synonyms
    bHLHa18, Lyl-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96891
    NCBI Gene: 17095
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85428078-85431569 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.02 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    99 from dbSNP Build 142
  • Strain Annotations
    15
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96891
 protein coding gene Chr8:85428051-85432876 (+)
129S1/SvImJ ENSMUSGG00200054653
 protein coding gene Chr8:79795928-79796188 (+)
A/J ENSMUSGG00195054901
 protein coding gene Chr8:80153968-80154228 (+)
AKR/J ENSMUSGG00220054555
 protein coding gene Chr8:80195475-80195735 (+)
BALB/cJ ENSMUSGG00180055237
 protein coding gene Chr8:79994616-79994876 (+)
C3H/HeJ ENSMUSGG00175055127
 protein coding gene Chr8:80089667-80089927 (+)
C57BL/6NJ ENSMUSGG00215055406
 protein coding gene Chr8:79726684-79726944 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031306
 protein coding gene Chr8:76036562-76039817 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054781
 protein coding gene Chr8:80076787-80077047 (+)
DBA/2J ENSMUSGG00185057932
 protein coding gene Chr8:86185378-86185638 (+)
FVB/NJ ENSMUSGG00205054074
 protein coding gene Chr8:79132605-79132865 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055855
 protein coding gene Chr8:89792937-89793197 (+)
NOD/ShiLtJ ENSMUSGG00190054788
 protein coding gene Chr8:80150908-80151168 (+)
NZO/HlLtJ ENSMUSGG00225055389
 protein coding gene Chr8:93187394-93187654 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010024125
 protein coding gene Chr8:81743942-81747330 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    LYL1, LYL1 basic helix-loop-helix family member
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LYL1, LYL1 basic helix-loop-helix family member
  • Synonyms
    bHLHa18
  • Links
    NCBI Gene ID: 4066
    UniProt: P12980

  • Chr Location
    19p13.13; chr19:13099033-13103161 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human LYL1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    5
  • Radiation induced
    1
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    2 involving Lyl1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    8 strains or lines available
Mice with mutation of this gene are vaible and fertile. Defects in production and differentiation of progenitor cells are observed, along with impaired ability of fetal liver or bone marrow cells in reconstituting B and T lineages after transplant.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    680
  • Tissues
    38
  • cDNA Data
    33
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034041 Ensembl Gene Model | MGI Sequence Detail 3492 C57BL/6J ±  kb
transcript ENSMUST00000037165 Ensembl | MGI Sequence Detail 1714 Not Applicable  
polypeptide ENSMUSP00000046010 Ensembl | MGI Sequence Detail 278 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    Genomic 5
    cDNA 33

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-12067, MGD-MRK-12068
References
more
  • Summaries
    All 100
    Developmental Gene Expression 9
    Gene Ontology 7
    Phenotypes 53
  • Earliest
    J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
  • Latest
    J:348117 Okuma H, et al., N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on alpha-dystroglycan and prevents muscular dystrophy. Elife. 2023 Feb 1;12
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory