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Ly6d Gene Detail
Summary
  • Symbol
    Ly6d
  • Name
    lymphocyte antigen 6 family member D
  • Synonyms
    Ly61, Ly-61, Thb
  • Feature Type
    protein coding gene
  • IDs
    MGI:96881
    NCBI Gene: 17068
  • Member of
    Ly6 cluster
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:74633905-74635416 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 34.27 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    23 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96881
 protein coding gene Chr15:74633905-74635469 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021937
 protein coding gene Chr15:74548003-74549574 (-)
A/J MGP_AJ_G0021896
 protein coding gene Chr15:71890561-71892125 (-)
AKR/J MGP_AKRJ_G0021878
 protein coding gene Chr15:73727633-73729197 (-)
BALB/cJ MGP_BALBcJ_G0021903
 protein coding gene Chr15:71896794-71898358 (-)
C3H/HeJ MGP_C3HHeJ_G0021676
 protein coding gene Chr15:73880909-73882473 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022343
 protein coding gene Chr15:77358739-77360303 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019879
 protein coding gene Chr15:68293453-68295009 (-)
CAST/EiJ MGP_CASTEiJ_G0021195
 protein coding gene Chr15:74701360-74702931 (-)
CBA/J MGP_CBAJ_G0021642
 protein coding gene Chr15:79897577-79899141 (-)
DBA/2J MGP_DBA2J_G0021767
 protein coding gene Chr15:71481345-71482909 (-)
FVB/NJ MGP_FVBNJ_G0021749
 protein coding gene Chr15:70530376-70531940 (-)
LP/J MGP_LPJ_G0021839
 protein coding gene Chr15:74604404-74605968 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021772
 protein coding gene Chr15:85208982-85210546 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022364
 protein coding gene Chr15:74116836-74118400 (-)
PWK/PhJ MGP_PWKPhJ_G0020936
 protein coding gene Chr15:71591986-71593557 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020777
 protein coding gene Chr15:74000606-74002178 (-)
WSB/EiJ MGP_WSBEiJ_G0021247
 protein coding gene Chr15:74126159-74127723 (-)



Homology
more
  • Human Ortholog
    LY6D, lymphocyte antigen 6 family member D
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LY6D, lymphocyte antigen 6 family member D
  • Synonyms
    E48, Ly-6D
  • Links
    NCBI Gene ID: 8581
    neXtProt AC: NX_Q14210
    UniProt: Q14210

  • Chr Location
    8q24.3; chr8:142784882-142786539 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    3
  • Endonuclease-mediated
    4
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    5 involving Ly6d
  • Find Mice (IMSR)
    11 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    10
  • cDNA Data
    47
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17068 NCBI Gene Model | MGI Sequence Detail 1512 C57BL/6J ±  kb
transcript NM_010742 RefSeq | MGI Sequence Detail 694 ZRU/MplStud  
polypeptide P35459 UniProt | EBI | MGI Sequence Detail 127 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 52
    Genomic 3
    cDNA 47
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12003, MGD-MRK-12046, MGD-MRK-15080
References
more
  • Summaries
    All 69
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 5
    Phenotypes 29
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:335177 Steiner I, et al., Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells. Cell Rep. 2023 Apr 13;42(4):112377
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory