About   Help   FAQ
Alad
Gene Detail
Symbol

Name
ID
Alad
aminolevulinate, delta-, dehydratase
MGI:96853
Synonyms
Lv
Feature Type
protein coding gene
Genetic Map
Chromosome 4
33.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
Chr4:62509169-62519918 bp, - strand
From VEGA annotation of GRCm38

  10750 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ALAD
Protein SuperFamily: porphobilinogen synthase
Gene Tree: Alad

Human
homologs
ALAD, aminolevulinate dehydratase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 210
neXtProt AC: NX_P13716

Human Synonyms: ALADH, PBGS

Human Chr (Location): 9q33.1; chr9:113386312-113401338 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ALAD

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(13) Targeted(4)
Incidental mutations (data from APF )
Interactions
Alad interacts with 10 markers (Mir29b-1, Mir30a, Mir30d, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process cellular response to interleukin-4, heme biosynthetic process, ...
Component cytosol, extracellular exosome, ...
Function catalytic activity, identical protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (130)    Tissues (101)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 116
RNase protection 8
Nuclease S1 6
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase alad ; ZFIN alad    NEW 
Molecular
reagents
All nucleic(34) Genomic(14) cDNA(20)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000009022 (Evidence)
Ensembl Gene Model ENSMUSG00000028393 (Evidence)
Entrez Gene 17025 (Evidence)
NIA Mouse Gene Index U025144
EC 4.2.1.24
PDB 2Z0I, 2Z1B
Consensus CDS Project CCDS18243.1
International Mouse Phenotyping Consortium Status Alad
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009022 VEGA Gene Model | MGI Sequence Detail 10750 C57BL/6J ±  kb
transcript OTTMUST00000020467 VEGA | MGI Sequence Detail 1247 Not Applicable 
polypeptide OTTMUSP00000009377 VEGA | MGI Sequence Detail 330 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(6) UniProt(4)
Polymorphisms
RFLP(10) : SNPs within 2kb(110 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013785 Aldolase-type TIM barrel
InterPro IPR001731 Porphobilinogen synthase
Protein Ontology PR:000003915 delta-aminolevulinic acid dehydratase
References
(Earliest) J:14972 Russell RL, et al., Genetic control of hepatic delta-aminolevulinate dehydratase in mice. Genetics. 1963 Aug;48:1033-39
(Latest) J:198500 Nakahara M, et al., Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Mamm Genome. 2013 Jun;24(5-6):228-39
All references(63)
Other
accession IDs
MGD-MRK-11931

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/28/2015
MGI 5.22
The Jackson Laboratory