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Alad
Gene Detail
 Symbol
Name
ID
Alad
aminolevulinate, delta-, dehydratase
MGI:96853
Synonyms Lv
Feature Type protein coding gene
Genetic Map
Chromosome 4
33.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
Chr4:62509169-62519918 bp, - strand
From VEGA annotation of GRCm38

  10750 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: porphobilinogen synthase
Gene Tree: Alad

Human
homologs
Human Homolog ALAD, aminolevulinate dehydratase
NCBI Gene ID 210
neXtProt AC  NX_P13716
Human Synonyms  ALADH, PBGS
Human Chr (Location)  9q33.1; chr9:113386312-113401338 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ALAD
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(13) Targeted(4)
Incidental mutations (data from APF )
Interactions
Alad interacts with 10 markers (Mir29b-1, Mir30a, Mir30d, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cellular response to interleukin-4, heme biosynthetic process, ...
Component cytosol, extracellular space, ...
Function catalytic activity, identical protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (130)    Tissues (101)    Images (24)
Theiler Stages: 15, 22, 23, 28
Assay TypeResults
RNA in situ 116
RNase protection 8
Nuclease S1 6
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) Genomic(14) cDNA(20)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000009022 (Evidence)
Ensembl Gene ModelENSMUSG00000028393 (Evidence)
Entrez Gene17025 (Evidence)
NIA Mouse Gene IndexU025144
EC4.2.1.24
PDB2Z0I, 2Z1B
Consensus CDS ProjectCCDS18243.1
International Mouse Knockout Project StatusAlad
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009022 VEGA Gene Model | MGI Sequence Detail 10750 C57BL/6J ±  kb
transcript OTTMUST00000020467 VEGA | MGI Sequence Detail 1247 Not Applicable 
polypeptide OTTMUSP00000009377 VEGA | MGI Sequence Detail 330 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(6) UniProt(4)
Polymorphisms RFLP(10) : SNPs within 2kb(110 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013785 Aldolase-type TIM barrel
InterPro IPR001731 Porphobilinogen synthase
Protein Ontology PR:000003915 delta-aminolevulinic acid dehydratase
References (Earliest) J:14972 Russell RL, et al., Genetic control of hepatic delta-aminolevulinate dehydratase in mice. Genetics. 1963 Aug;48:1033-39
(Latest) J:198500 Nakahara M, et al., Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Mamm Genome. 2013 Jun;24(5-6):228-39
All references(63)
Other
accession IDs
MGD-MRK-11931

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory