Alad
Gene Detail

Symbol Name ID

Alad aminolevulinate, delta-, dehydratase MGI:96853

Synonyms

Lv

Feature Type

protein coding gene

Genetic Map

Chromosome 4

33.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)

Sequence Map

Chr4:62509169-62519918 bp, - strand From VEGA annotation of GRCm38   10750 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:16  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: porphobilinogen synthase
Gene Tree: Alad

Human homologs

Human Homolog		ALAD, aminolevulinate dehydratase
NCBI Gene ID		210
neXtProt AC		NX_P13716
Human Synonyms		ALADH, PBGS
Human Chr (Location)		9q33.1; chr9:116148592-116163618 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ALAD

Alleles and phenotypes

All alleles(17) : Targeted(4) Gene trapped(13)

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	cellular response to interleukin-4, heme biosynthetic process, ...
Component	cytosol, extracellular space
Function	catalytic activity, identical protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (130)    Tissues (101)    Images (24)
Theiler Stages: 15, 22, 23, 28

Assay Type	Results
RNA in situ	116
RNase protection	8
Nuclease S1	6

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(34) Genomic(14) cDNA(20)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000009022 (Evidence)
Ensembl Gene Model	ENSMUSG00000028393 (Evidence)
Entrez Gene	17025 (Evidence)
NIA Mouse Gene Index	U025144
EC	4.2.1.24
PDB	2Z0I, 2Z1B
Consensus CDS Project	CCDS18243.1
International Mouse Knockout Project Status	Alad

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009022	VEGA Gene Model | MGI Sequence Detail	10750	C57BL/6J
transcript	OTTMUST00000020467	VEGA | MGI Sequence Detail	1247	Not Applicable
polypeptide	OTTMUSP00000009377	VEGA | MGI Sequence Detail	330	Not Applicable

All sequences(41) RefSeq(4) UniProt(4)

Polymorphisms

RFLP(10) : SNPs(59 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013785	Aldolase-type TIM barrel
InterPro	IPR001731	Porphobilinogen synthase
Protein Ontology	PR:000003915	delta-aminolevulinic acid dehydratase

References

(Earliest) J:14972 Russell RL, et al., Genetic control of hepatic delta-aminolevulinate dehydratase in mice. Genetics. 1963 Aug;48:1033-39
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(62)

Other accession IDs

MGD-MRK-11931