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Ltk
Gene Detail
Symbol

Name
ID
Ltk
leukocyte tyrosine kinase
MGI:96840
Feature Type
protein coding gene
Genetic Map
Chromosome 2
59.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
Chr2:119751320-119760431 bp, - strand
From VEGA annotation of GRCm38

  9112 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:130502  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

HCOP human homology predictions: LTK
Gene Tree: Ltk

Human
homologs
LTK, leukocyte receptor tyrosine kinase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4058
neXtProt AC: NX_P29376

Human Synonyms: TYK1

Human Chr (Location): 15q15.1-q21.1; chr15:41503637-41513887 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Ltk interacts with 43 markers (Mir1a-1, Mir1a-2, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cell proliferation, cellular response to retinoic acid, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 4
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA LTK ZFIN ltk    NEW 
Molecular
reagents
All nucleic(19) Genomic(3) cDNA(14) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016528 (Evidence)
Ensembl Gene Model ENSMUSG00000027297 (Evidence)
Entrez Gene 17005 (Evidence)
UniGene 1740
DFCI TC1591502, TC1592993, TC1597896, TC1603242
DoTS DT.101333646, DT.103583624, DT.103583643, DT.110708309, DT.40185620, DT.94186325
NIA Mouse Gene Index U023233
EC 2.7.10.1
Consensus CDS Project CCDS16608.1, CCDS16609.1, CCDS50674.1
International Mouse Phenotyping Consortium Status Ltk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016528 VEGA Gene Model | MGI Sequence Detail 9112 C57BL/6J ±  kb
transcript OTTMUST00000039950 VEGA | MGI Sequence Detail 3080 Not Applicable 
polypeptide OTTMUSP00000017811 VEGA | MGI Sequence Detail 888 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(8) UniProt(4)
Polymorphisms
All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026984 Leukocyte tyrosine kinase receptor
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Protein Ontology PR:000009979 leukocyte tyrosine kinase receptor
References
(Earliest) J:9195 Ben-Neriah Y, et al., Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain. Nature. 1988 Jun 16;333(6174):672-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(46)
Other
accession IDs
MGD-MRK-11904

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory