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Ltk
Gene Detail
 Symbol
Name
ID
Ltk
leukocyte tyrosine kinase
MGI:96840
Feature Type protein coding gene
Genetic Map
Chromosome 2
59.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
Chr2:119751320-119760431 bp, - strand
From VEGA annotation of GRCm38

  9112 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:130502  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 chicken

Gene Tree: Ltk

Human
homologs
Human Homolog LTK, leukocyte receptor tyrosine kinase
NCBI Gene ID 4058
neXtProt AC  NX_P29376
Human Synonyms  TYK1
Human Chr (Location)  15q15.1-q21.1; chr15:41503642-41513887 (-)  GRCh38
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cell proliferation, cellular response to retinoic acid, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (4)   
Theiler Stages: 22, 24, 26, 28
Assay TypeResults
RNA in situ 4
cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(19) Genomic(3) cDNA(14) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016528 (Evidence)
Ensembl Gene ModelENSMUSG00000027297 (Evidence)
Entrez Gene17005 (Evidence)
UniGene1740
DFCITC1591502, TC1592993, TC1597896, TC1603242
DoTSDT.101333646, DT.103583624, DT.103583643, DT.110708309, DT.40185620, DT.94186325
NIA Mouse Gene IndexU023233
EC2.7.10.1
Consensus CDS ProjectCCDS16608.1, CCDS16609.1, CCDS50674.1
International Mouse Knockout Project StatusLtk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016528 VEGA Gene Model | MGI Sequence Detail 9112 C57BL/6J ±  kb
transcript OTTMUST00000039950 VEGA | MGI Sequence Detail 3080 Not Applicable 
polypeptide OTTMUSP00000017811 VEGA | MGI Sequence Detail 888 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(8) UniProt(4)
Polymorphisms All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026984 Leukocyte tyrosine kinase receptor
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Protein Ontology PR:000009979 leukocyte tyrosine kinase receptor
References (Earliest) J:9195 Ben-Neriah Y, et al., Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain. Nature. 1988 Jun 16;333(6174):672-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(48)
Other
accession IDs
MGD-MRK-11904

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory