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Ltf
Gene Detail
Symbol

Name
ID
Ltf
lactotransferrin
MGI:96837
STS
Synonyms
lactoferrin, Lf
Feature Type
protein coding gene
Genetic Map
Chromosome 9
60.79 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr9:111019271-111042767 bp, + strand
From VEGA annotation of GRCm38

  23497 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1754  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

HCOP human homology predictions: LTF
Protein SuperFamily: transferrin
Gene Tree: Ltf

Human
homologs
LTF, lactotransferrin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4057
neXtProt AC: NX_P02788

Human Synonyms: GIG12, HEL110, HLF2, LF

Human Chr (Location): 3p21.31; chr3:46436005-46465142 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele are viable, fertile and grossly normal, and exhibit only minor alterations in iron homeostasis.
 
Interactions
Ltf interacts with 92 markers (Mir16-1, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process activation of protein kinase activity, antibacterial humoral response, ...
Component cell surface, cytoplasm, ...
Function heparin binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (71)    Tissues (37)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 15
RNA in situ 46
In situ reporter (knock in) 2
Northern blot 4
RT-PCR 4
cDNA source data(1666)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TF    NEW 
Molecular
reagents
All nucleic(1679) Genomic(11) cDNA(1666) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000052503 (Evidence)
Ensembl Gene Model ENSMUSG00000032496 (Evidence)
Entrez Gene 17002 (Evidence)
UniGene 282359
DFCI TC1573675
DoTS DT.101363862, DT.91537153, DT.91576545, DT.94223474, DT.97395696, DT.98132215
NIA Mouse Gene Index U011078
EC 3.4.21.-
Consensus CDS Project CCDS23581.1
International Mouse Phenotyping Consortium Status Ltf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052503 VEGA Gene Model | MGI Sequence Detail 23497 C57BL/6J ±  kb
transcript OTTMUST00000131662 VEGA | MGI Sequence Detail 2743 Not Applicable 
polypeptide OTTMUSP00000070348 VEGA | MGI Sequence Detail 707 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(2) UniProt(14)
Polymorphisms
SNPs within 2kb(283 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR030684 Lactotransferrin
InterPro IPR016357 Transferrin
InterPro IPR018195 Transferrin family, iron binding site
InterPro IPR001156 Transferrin-like domain
Protein Ontology PR:000009978 lactotransferrin
References
(Earliest) J:8905 Teng CT, et al., Assignment of the lactotransferrin gene to human chromosome 3 and to mouse chromosome 9. Somat Cell Mol Genet. 1987 Nov;13(6):689-93
(Latest) J:218509 Kim HJ, et al., Patterns of gene expression associated with Pten deficiency in the developing inner ear. PLoS One. 2014;9(6):e97544
All references(59)
Other
accession IDs
MGD-MRK-11899

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory