Ltf
Gene Detail

Symbol Name ID

Ltf lactotransferrin MGI:96837

STS

D9Mit38

Synonyms

lactoferrin, Lf

Feature Type

protein coding gene

Genetic Map

Chromosome 9

60.79 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr9:111019292-111042766 bp, + strand From NCBI annotation of GRCm38   23475 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1754  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog

Protein SuperFamily: transferrin
Gene Tree: Ltf

Human homologs

Human Homolog		LTF, lactotransferrin
NCBI Gene ID		4057
neXtProt AC		NX_P02788
Human Synonyms		GIG12, HLF2, LF
Human Chr (Location)		3p21.31; chr3:46477496-46506598 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele are viable, fertile and grossly normal, and exhibit only minor alterations in iron homeostasis.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	cellular iron ion homeostasis, ion transport, ...
Component	cytoplasm, extracellular region, ...
Function	ferric iron binding, heparin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (70)    Tissues (36)    Images (24)
Theiler Stages: 2, 3, 4, 5, 19, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	15
RNA in situ	46
Northern blot	4
RT-PCR	5

cDNA source data(1666)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(1679) Genomic(11) cDNA(1666) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000032496 (Evidence)
Entrez Gene	17002 (Evidence)
UniGene	282359
DFCI	TC1573675
DoTS	DT.101363862, DT.91537153, DT.91576545, DT.94223474, DT.97395696, DT.98132215
NIA Mouse Gene Index	U011078
EC	3.4.21.-
Consensus CDS Project	CCDS23581.1
International Mouse Knockout Project Status	Ltf

Sequences

Length	Strain/Species
genomic	17002	NCBI Gene Model | MGI Sequence Detail	23475	C57BL/6J
transcript	NM_008522	RefSeq | MGI Sequence Detail	2742	C57BL/6
polypeptide	P08071	UniProt | EBI | MGI Sequence Detail	707	Not Applicable

All sequences(42) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(155 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016357	Transferrin
InterPro	IPR001156	Transferrin family
InterPro	IPR018195	Transferrin family, iron binding site
Protein Ontology	PR:000009978	lactotransferrin

Graphical View of Protein Domain Structure

References

(Earliest) J:8905 Teng CT, et al., Assignment of the lactotransferrin gene to human chromosome 3 and to mouse chromosome 9. Somat Cell Mol Genet. 1987 Nov;13(6):689-93
(Latest) J:178944 Daikoku T, et al., Conditional Deletion of MSX Homeobox Genes in the Uterus Inhibits Blastocyst Implantation by Altering Uterine Receptivity. Dev Cell. 2011 Dec 13;21(6):1014-25
All references(57)

Other accession IDs

MGD-MRK-11899