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Ltf
Gene Detail
 Symbol
Name
ID
Ltf
lactotransferrin
MGI:96837
STS D9Mit38
Synonyms lactoferrin, Lf
Feature Type protein coding gene
Genetic Map
Chromosome 9
60.79 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr9:111019292-111042766 bp, + strand
From NCBI annotation of GRCm38

  23475 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1754  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog

Protein SuperFamily: transferrin
Gene Tree: Ltf

Human
homologs
Human Homolog LTF, lactotransferrin
NCBI Gene ID 4057
neXtProt AC  NX_P02788
Human Synonyms  GIG12, HEL110, HLF2, LF
Human Chr (Location)  3p21.31; chr3:46436005-46465142 (-)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
 
Mice homozygous for a knock-out allele are viable, fertile and grossly normal, and exhibit only minor alterations in iron homeostasis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process antibacterial humoral response, antifungal humoral response, ...
Component cytoplasm, extracellular region, ...
Function ferric iron binding, heparin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (70)    Tissues (36)    Images (24)
Theiler Stages: 2, 3, 4, 5, 19, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 15
RNA in situ 46
Northern blot 4
RT-PCR 5
cDNA source data(1666)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(1679) Genomic(11) cDNA(1666) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000032496 (Evidence)
Entrez Gene17002 (Evidence)
UniGene282359
DFCITC1573675
DoTSDT.101363862, DT.91537153, DT.91576545, DT.94223474, DT.97395696, DT.98132215
NIA Mouse Gene IndexU011078
EC3.4.21.-
Consensus CDS ProjectCCDS23581.1
International Mouse Knockout Project StatusLtf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17002 NCBI Gene Model | MGI Sequence Detail 23475 C57BL/6J ±  kb
transcript NM_008522 RefSeq | MGI Sequence Detail 2742 C57BL/6 
polypeptide P08071 UniProt | EBI | MGI Sequence Detail 707 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(2) UniProt(6)
Polymorphisms SNPs within 2kb(283 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016357 Transferrin
InterPro IPR001156 Transferrin family
InterPro IPR018195 Transferrin family, iron binding site
Protein Ontology PR:000009978 lactotransferrin
Graphical View of Protein Domain Structure
References (Earliest) J:8905 Teng CT, et al., Assignment of the lactotransferrin gene to human chromosome 3 and to mouse chromosome 9. Somat Cell Mol Genet. 1987 Nov;13(6):689-93
(Latest) J:178944 Daikoku T, et al., Conditional Deletion of MSX Homeobox Genes in the Uterus Inhibits Blastocyst Implantation by Altering Uterine Receptivity. Dev Cell. 2011 Dec 13;21(6):1014-25
All references(58)
Other
accession IDs
MGD-MRK-11899

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory