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Ltf Gene Detail
Summary
  • Symbol
    Ltf
  • Name
    lactotransferrin
  • Synonyms
    lactoferrin, Lf
  • Feature Type
    protein coding gene
  • IDs
    MGI:96837
    NCBI Gene: 17002
  • Gene Overview
    MyGene.info: LTF
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:111019292-111042766 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 60.79 cM, cytoband F
  • Mapping Data
    7 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    265 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96837
protein coding gene Chr9:111019271-111042767 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035368
protein coding gene Chr9:113216147-113243304 (+)
A/J MGP_AJ_G0035349
protein coding gene Chr9:109088089-109111521 (+)
AKR/J MGP_AKRJ_G0035280
protein coding gene Chr9:111808128-111831440 (+)
BALB/cJ MGP_BALBcJ_G0035344
protein coding gene Chr9:108838627-108864194 (+)
C3H/HeJ MGP_C3HHeJ_G0035052
protein coding gene Chr9:112307055-112333008 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035866
protein coding gene Chr9:116348335-116373309 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032752
protein coding gene Chr9:106299323-106322873 (+)
CAST/EiJ MGP_CASTEiJ_G0034358
protein coding gene Chr9:112109616-112136021 (+)
CBA/J MGP_CBAJ_G0035019
protein coding gene Chr9:120620277-120654517 (+)
DBA/2J MGP_DBA2J_G0035178
protein coding gene Chr9:108542600-108566197 (+)
FVB/NJ MGP_FVBNJ_G0035125
protein coding gene Chr9:107387324-107412348 (+)
LP/J MGP_LPJ_G0035257
protein coding gene Chr9:113507567-113531708 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035165
protein coding gene Chr9:121941677-121968672 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035886
protein coding gene Chr9:112152999-112180647 (+)
PWK/PhJ MGP_PWKPhJ_G0034065
protein coding gene Chr9:108788778-108813368 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033900
protein coding gene Chr9:112239801-112268065 (+)
WSB/EiJ MGP_WSBEiJ_G0034479
protein coding gene Chr9:112021566-112046369 (+)



Homology
more
  • Human Ortholog
    LTF, lactotransferrin
  • Vertebrate Orthologs
    6
  • Human Ortholog
    LTF, lactotransferrin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GIG12, HEL110, HLF2, LF
  • Links
    NCBI Gene ID: 4057
    neXtProt AC: NX_P02788
    UniProt: P02788

  • Chr Location
    3p21.31; chr3:46436005-46485234 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    2 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, fertile, and grossly normal and exhibit only minor alterations in iron homeostasis. Mice homozygous for a different knock-out allele show increased susceptibility to inflammation-induced colorectal dysplasia along with increased cell proliferation and decreased apoptosis in colonic tissues.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17002 NCBI Gene Model | MGI Sequence Detail 23475 C57BL/6J ±  kb
    transcript NM_008522 RefSeq | MGI Sequence Detail 2742 C57BL/6  
    polypeptide P08071 UniProt | EBI | MGI Sequence Detail 707 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1680
      Genomic 11
      cDNA 1667
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11899
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 17
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:8905 Teng CT, et al., Assignment of the lactotransferrin gene to human chromosome 3 and to mouse chromosome 9. Somat Cell Mol Genet. 1987 Nov;13(6):689-93
    • Latest
      J:265444 Matsumoto L, et al., HIF2alpha in the uterine stroma permits embryo invasion and luminal epithelium detachment. J Clin Invest. 2018 Jul 2;128(7):3186-3197

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory