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Ltf Gene Detail
Summary
  • Symbol
    Ltf
  • Name
    lactotransferrin
  • Synonyms
    lactoferrin, Lf
  • Feature Type
    protein coding gene
  • IDs
    MGI:96837
    NCBI Gene: 17002
  • Gene Overview
    MyGene.info: LTF
Location & Maps
more
  • Sequence Map
    Chr9:111019271-111042767 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23497 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 60.79 cM, cytoband F
  • Mapping Data
    7 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    LTF, lactotransferrin
  • Vertebrate Orthologs
    6
  • Human Ortholog
    LTF, lactotransferrin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GIG12, HEL110, HLF2, LF
  • Links
    NCBI Gene ID: 4057
    neXtProt AC: NX_P02788

  • Chr Location
    3p21.31; chr3:46436005-46465142 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    2 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, fertile, and grossly normal and exhibit only minor alterations in iron homeostasis. Mice homozygous for a different knock-out allele show increased susceptibility to inflammation-induced colorectal dysplasia along with increased cell proliferation and decreased apoptosis in colonic tissues.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052503 VEGA Gene Model | MGI Sequence Detail 23497 C57BL/6J ±  kb
transcript OTTMUST00000131662 VEGA | MGI Sequence Detail 2743 Not Applicable  
polypeptide OTTMUSP00000070348 VEGA | MGI Sequence Detail 707 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    265 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 1679
    Genomic 11
    cDNA 1666
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11899
References
more
  • Summaries
    All 59
    Developmental Gene Expression 14
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:8905 Teng CT, et al., Assignment of the lactotransferrin gene to human chromosome 3 and to mouse chromosome 9. Somat Cell Mol Genet. 1987 Nov;13(6):689-93
  • Latest
    J:232939 Antonson P, et al., Identification of proteins highly expressed in uterine fluid from mice with hydrometra. Biochem Biophys Res Commun. 2015 Oct 30;466(4):650-5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory