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Lsp1 Gene Detail
Summary
  • Symbol
    Lsp1
  • Name
    lymphocyte specific 1
  • Synonyms
    leukocyte specific protein 1, leukocyte-specific protein 1, Lsp-1, lymphocyte-specific protein 1, p50, pp52, WP34
  • Feature Type
    protein coding gene
  • IDs
    MGI:96832
    NCBI Gene: 16985
  • Gene Overview
    MyGene.info: LSP1
Location & Maps
more
  • Sequence Map
    Chr7:142460809-142494867 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      34059 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 87.93 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    LSP1, lymphocyte-specific protein 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    LSP1, lymphocyte-specific protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    pp52, WP34
  • Links
    NCBI Gene ID: 4046
    neXtProt AC: NX_P33241

  • Chr Location
    11p15.5; chr11:1852970-1892263 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Lsp1
  • Incidental Mutations
    Mutagenetix , APF
Homozygotes for a targeted null mutation exhibit increased numbers of resident peritoneal macrophages and reduced numbers of peritoneal lymphocytes. Mutant neutrophils show abnormal morphology and impaired chemokine-induced migration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    127
  • Tissues
    43
  • cDNA Data
    79
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018784 VEGA Gene Model | MGI Sequence Detail 34059 C57BL/6J ±  kb
transcript OTTMUST00000045189 VEGA | MGI Sequence Detail 1727 Not Applicable  
polypeptide OTTMUSP00000020314 VEGA | MGI Sequence Detail 330 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    124 from dbSNP Build 142
  • RFLP
    1
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000009967 lymphocyte-specific protein 1
  • InterPro Domains
    IPR006018 Caldesmon/lymphocyte specific protein
    IPR002211 Lymphocyte-specific protein
Molecular
Reagents
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  • All nucleic 87
    Genomic 6
    cDNA 79
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11892, MGD-MRK-11893
References
more
  • Summaries
    All 43
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 16
  • Earliest
    J:9449 Jongstra J, et al., A new lymphocyte-specific gene which encodes a putative Ca2+-binding protein is not expressed in transformed T lymphocyte lines. J Immunol. 1988 Dec 1;141(11):3999-4004
  • Latest
    J:228060 Hwang SH, et al., Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6535-43
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory