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Lsp1
Gene Detail
 Symbol
Name
ID
Lsp1
lymphocyte specific 1
MGI:96832
Synonyms leukocyte specific protein 1, leukocyte-specific protein 1, Lsp-1, lymphocyte-specific protein 1, p50, pp52, WP34
Feature Type protein coding gene
Genetic Map
Chromosome 7
87.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:142460809-142494867 bp, + strand
From VEGA annotation of GRCm38

  34059 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1750  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Lsp1

Human
homologs
Human Homolog LSP1, lymphocyte-specific protein 1
NCBI Gene ID 4046
neXtProt AC  NX_P33241
Human Synonyms  pp52, WP34
Human Chr (Location)  11p15.5; chr11:1852970-1892263 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit increased numbers of resident peritoneal macrophages and reduced numbers of peritoneal lymphocytes. Mutant neutrophils show abnormal morphology and impaired chemokine-induced migration.
 
Interactions
Lsp1 interacts with 106 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process apoptotic process, chemotaxis, ...
Component extracellular vesicular exosome, membrane, ...
Function actin binding, signal transducer activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (127)    Tissues (43)    Images (28)
Theiler Stages: 17, 20, 21, 22, 23, 24, 25
Assay TypeResults
RNA in situ 115
Northern blot 5
RT-PCR 7
cDNA source data(79)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(87) Genomic(6) cDNA(79) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000018784 (Evidence)
Ensembl Gene ModelENSMUSG00000018819 (Evidence)
Entrez Gene16985 (Evidence)
UniGene234003
DFCITC1580216, TC1591200, TC1594075, TC1595400, TC1599596
DoTSDT.101379048, DT.101736267, DT.101736268, DT.91340842, DT.94268108, DT.97404784
NIA Mouse Gene IndexU199741
Consensus CDS ProjectCCDS40193.1, CCDS52450.1, CCDS72072.1, CCDS72073.1
International Mouse Knockout Project StatusLsp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018784 VEGA Gene Model | MGI Sequence Detail 34059 C57BL/6J ±  kb
transcript OTTMUST00000045189 VEGA | MGI Sequence Detail 1727 Not Applicable 
polypeptide OTTMUSP00000020314 VEGA | MGI Sequence Detail 330 Not Applicable 

For the selected sequences
All sequences(88) RefSeq(20) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(124 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006018 Caldesmon/lymphocyte specific protein
InterPro IPR002211 Lymphocyte-specific protein
Protein Ontology PR:000009967 lymphocyte-specific protein 1
References (Earliest) J:9449 Jongstra J, et al., A new lymphocyte-specific gene which encodes a putative Ca2+-binding protein is not expressed in transformed T lymphocyte lines. J Immunol. 1988 Dec 1;141(11):3999-4004
(Latest) J:200793 Sabbagh L, et al., Leukocyte-specific protein 1 links TNF receptor-associated factor 1 to survival signaling downstream of 4-1BB in T cells. J Leukoc Biol. 2013 May;93(5):713-21
All references(49)
Other
accession IDs
MGD-MRK-11892, MGD-MRK-11893

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory