Lsp1 MGI Mouse Gene Detail - MGI:96832

Symbol

Lsp1
Name

lymphocyte specific 1
Synonyms

leukocyte specific protein 1, leukocyte-specific protein 1, Lsp-1, lymphocyte-specific protein 1, p50, pp52, WP34

Feature Type

protein coding gene
IDs

MGI:96832
NCBI Gene: 16985
Alliance

gene page
Transcription Start Sites

22 TSS

Sequence Map

Chr7:142014583-142048605 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 87.93 cM
Mapping Data

4 experiments

SNPs within 2kb

922 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96832	protein coding gene	Chr7:142014546-142048605 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033257	protein coding gene	Chr7:147717849-147751906 (+)
A/J	MGP_AJ_G0033240	protein coding gene	Chr7:143453428-143487487 (+)
AKR/J	MGP_AKRJ_G0033172	protein coding gene	Chr7:147481255-147515312 (+)
BALB/cJ	MGP_BALBcJ_G0033241	protein coding gene	Chr7:143225527-143259542 (+)
C3H/HeJ	MGP_C3HHeJ_G0032956	protein coding gene	Chr7:147238262-147274718 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033751	protein coding gene	Chr7:153062329-153096378 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030724	protein coding gene	Chr7:144661382-144696478 (+)
CAST/EiJ	MGP_CASTEiJ_G0032279	protein coding gene	Chr7:139550252-139584411 (+)
CBA/J	MGP_CBAJ_G0032927	protein coding gene	Chr7:158308316-158342373 (+)
DBA/2J	MGP_DBA2J_G0033081	protein coding gene	Chr7:141406383-141440440 (+)
FVB/NJ	MGP_FVBNJ_G0033030	protein coding gene	Chr7:141341470-141375517 (+)
LP/J	MGP_LPJ_G0033174	protein coding gene	Chr7:149228233-149262290 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033064	protein coding gene	Chr7:158927307-158961360 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033770	protein coding gene	Chr7:146429629-146463686 (+)
PWK/PhJ	MGP_PWKPhJ_G0031987	protein coding gene	Chr7:134733701-134768122 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031833	protein coding gene	Chr7:133228997-133263057 (+)
WSB/EiJ	MGP_WSBEiJ_G0032391	protein coding gene	Chr7:147407570-147441629 (+)

Human Ortholog

LSP1, lymphocyte specific protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LSP1, lymphocyte specific protein 1
Synonyms

pp52, WP34
Links

HGNC:6707

NCBI Gene ID: 4046

UniProt: P33241
Chr Location

11p15.5; chr11:1850904-1892267 (+) GRCh38

MGI Vertebrate Homology

Lsp1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: LSP1
Gene Tree

Lsp1

Diseases

1 with human LSP1 associations

				Human Disease	Mouse Models
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Gene trapped

2
Radiation induced

1
Targeted

3
Genomic Mutations

1 involving Lsp1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available

Homozygotes for a targeted null mutation exhibit increased numbers of resident peritoneal macrophages and reduced numbers of peritoneal lymphocytes. Mutant neutrophils show abnormal morphology and impaired chemokine-induced migration.

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

836
Tissues

45
cDNA Data

80
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA LSP1P1

Xenbase lsp1

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All Sequences

101
RefSeq

44
UniProt

5
CCDS

CCDS40193.1, CCDS52450.1, CCDS72072.1, CCDS72073.1, CCDS85469.1

Ensembl

ENSMUSG00000018819 (Evidence)
NCBI Gene

16985

			Length	Strain/Species	Flank
genomic	16985	NCBI Gene Model \| MGI Sequence Detail	34023	C57BL/6J	± kb
transcript	NM_019391	RefSeq \| MGI Sequence Detail	2077	ZRU/MplStud
polypeptide	P19973	UniProt \| EBI \| MGI Sequence Detail	330	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000009967 lymphocyte-specific protein 1

(term hierarchy)
InterPro Domains

IPR006018 Caldesmon/lymphocyte specific protein

IPR002211 Lymphocyte-specific protein
GlyGen

P19973 2 sites, 1 O-linked glycan (1 site)

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All nucleic 88

Genomic 6

cDNA 80

Primer pair 2

Microarray probesets 3

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MGD-MRK-11892, MGD-MRK-11893

Summaries

All 58

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 20
Earliest

J:9449 Jongstra J, et al., A new lymphocyte-specific gene which encodes a putative Ca2+-binding protein is not expressed in transformed T lymphocyte lines. J Immunol. 1988 Dec 1;141(11):3999-4004
Latest

J:266351 Koral K, et al., Lymphocyte-Specific Protein-1 Controls Sorafenib Sensitivity and Hepatocellular Proliferation through Extracellular Signal-Regulated Kinase 1/2 Activation. Am J Pathol. 2018 Sep;188(9):2074-2086

TSS for Lsp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr70170	Chr7:142014560-142014569 (+)	-18 bp
Tssr70171	Chr7:142014571-142014623 (+)	14 bp
Tssr70172	Chr7:142020525-142020571 (+)	5,965 bp
Tssr70173	Chr7:142020669-142020678 (+)	6,091 bp
Tssr2455	Chr7:142025171-142025190 (+)	10,598 bp
Tssr70174	Chr7:142025495-142025514 (+)	10,922 bp
Tssr70175	Chr7:142025575-142025647 (+)	11,028 bp
Tssr2456	Chr7:142025738-142025749 (+)	11,161 bp
Tssr70176	Chr7:142025817-142025830 (+)	11,241 bp
Tssr70177	Chr7:142028727-142028738 (+)	14,150 bp
Tssr70178	Chr7:142028781-142028829 (+)	14,222 bp
Tssr70179	Chr7:142028909-142028942 (+)	14,343 bp
Tssr70180	Chr7:142030744-142030755 (+)	16,167 bp
Tssr70181	Chr7:142030784-142030794 (+)	16,206 bp
Tssr70182	Chr7:142035115-142035126 (+)	20,538 bp
Tssr70183	Chr7:142042571-142042587 (+)	27,996 bp
Tssr70184	Chr7:142042732-142042744 (+)	28,155 bp
Tssr70185	Chr7:142042776-142042805 (+)	28,208 bp
Tssr70186	Chr7:142042913-142042932 (+)	28,340 bp
Tssr70187	Chr7:142043037-142043065 (+)	28,468 bp
Tssr70188	Chr7:142043138-142043152 (+)	28,562 bp
Tssr70189	Chr7:142047980-142047997 (+)	33,406 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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