Lsp1 MGI Mouse Gene Detail - MGI:96832

Lsp1 Gene Detail

Symbol

Lsp1
Name

lymphocyte specific 1
Synonyms

leukocyte specific protein 1, leukocyte-specific protein 1, Lsp-1, lymphocyte-specific protein 1, p50, pp52, WP34

Feature Type

protein coding gene
IDs

MGI:96832
NCBI Gene: 16985
Gene Overview

MyGene.info: LSP1
Alliance

gene page

Sequence Map

Chr7:142460809-142494867 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

34059 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 87.93 cM
Mapping Data

4 experiments

Human Ortholog

LSP1, lymphocyte-specific protein 1

Vertebrate Orthologs

8

Human Ortholog

LSP1, lymphocyte-specific protein 1
Orthology source: HomoloGene, HGNC
Synonyms

pp52, WP34
Links

HGNC:6707

NCBI Gene ID: 4046

neXtProt AC: NX_P33241

UniProt: P33241
Chr Location

11p15.5; chr11:1852970-1892263 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 1750
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: LSP1
Gene Tree

Lsp1

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Gene trapped

2
Radiation induced

1
Targeted

3
Genomic Mutations

1 involving Lsp1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

7 strains or lines available

Homozygotes for a targeted null mutation exhibit increased numbers of resident peritoneal macrophages and reduced numbers of peritoneal lymphocytes. Mutant neutrophils show abnormal morphology and impaired chemokine-induced migration.

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All GO Annotations

9
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

127
Tissues

43
cDNA Data

79
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA LSP1

Xenbase lsp1

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Lsp1 interacts with 106 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

77
RefSeq

18
UniProt

5
CCDS

CCDS40193.1, CCDS52450.1, CCDS72072.1, CCDS72073.1, CCDS85469.1
UniGene

234003

			Length	Strain/Species	Flank
genomic	OTTMUSG00000018784	VEGA Gene Model \| MGI Sequence Detail	34059	C57BL/6J	± kb
transcript	OTTMUST00000045189	VEGA \| MGI Sequence Detail	1727	Not Applicable
polypeptide	OTTMUSP00000020314	VEGA \| MGI Sequence Detail	330	Not Applicable

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SNPs within 2kb

124 from dbSNP Build 142

RFLP

1

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UniProt

5 Sequences
Protein Ontology

PR:000009967 lymphocyte-specific protein 1

(term hierarchy)
InterPro Domains

IPR006018 Caldesmon/lymphocyte specific protein

IPR002211 Lymphocyte-specific protein

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All nucleic 87

Genomic 6

cDNA 79

Primer pair 2

Microarray probesets 3

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MGD-MRK-11892, MGD-MRK-11893

Summaries

All 53

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 18
Earliest

J:9449 Jongstra J, et al., A new lymphocyte-specific gene which encodes a putative Ca2+-binding protein is not expressed in transformed T lymphocyte lines. J Immunol. 1988 Dec 1;141(11):3999-4004
Latest

J:233976 Dupays L, et al., Sequential Binding of MEIS1 and NKX2-5 on the Popdc2 Gene: A Mechanism for Spatiotemporal Regulation of Enhancers during Cardiogenesis. Cell Rep. 2015 Oct 6;13(1):183-95

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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