Lsp1
Gene Detail

Symbol

Name
ID

Lsp1
lymphocyte specific 1
MGI:96832

Synonyms

leukocyte specific protein 1, leukocyte-specific protein 1, Lsp-1, lymphocyte-specific protein 1, p50, pp52, WP34

Feature Type

protein coding gene

Genetic Map

Chromosome 7
87.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr7:142460809-142494867 bp, + strand From VEGA annotation of GRCm38   34059 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:1750  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Lsp1

Human
homologs

Human Homolog		LSP1, lymphocyte-specific protein 1
NCBI Gene ID		4046
neXtProt AC		NX_P33241
Human Synonyms		pp52, WP34
Human Chr (Location)		11p15.5; chr11:1852970-1892263 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for a targeted null mutation exhibit increased numbers of resident peritoneal macrophages and reduced numbers of peritoneal lymphocytes. Mutant neutrophils show abnormal morphology and impaired chemokine-induced migration.

 

Interactions

Lsp1 interacts with 106 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (10 annotations)

Process	apoptotic process, chemotaxis, ...
Component	extracellular vesicular exosome, membrane, ...
Function	actin binding, signal transducer activity

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (127)    Tissues (43)    Images (28)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	115
Northern blot	5
RT-PCR	7

cDNA source data(79)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(87) Genomic(6) cDNA(79) Primer pair(2)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000018784 (Evidence)
Ensembl Gene Model	ENSMUSG00000018819 (Evidence)
Entrez Gene	16985 (Evidence)
UniGene	234003
DFCI	TC1580216, TC1591200, TC1594075, TC1595400, TC1599596
DoTS	DT.101379048, DT.101736267, DT.101736268, DT.91340842, DT.94268108, DT.97404784
Consensus CDS Project	CCDS40193.1, CCDS52450.1, CCDS72072.1, CCDS72073.1
International Mouse Knockout Project Status	Lsp1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018784	VEGA Gene Model | MGI Sequence Detail	34059	C57BL/6J
transcript	OTTMUST00000045189	VEGA | MGI Sequence Detail	1727	Not Applicable
polypeptide	OTTMUSP00000020314	VEGA | MGI Sequence Detail	330	Not Applicable

All sequences(85) RefSeq(18) UniProt(3)

Polymorphisms

RFLP(1) : SNPs within 2kb(124 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR006018	Caldesmon/lymphocyte specific protein
InterPro	IPR002211	Lymphocyte-specific protein
Protein Ontology	PR:000009967	lymphocyte-specific protein 1

References

(Earliest) J:9449 Jongstra J, et al., A new lymphocyte-specific gene which encodes a putative Ca2+-binding protein is not expressed in transformed T lymphocyte lines. J Immunol. 1988 Dec 1;141(11):3999-4004
(Latest) J:200793 Sabbagh L, et al., Leukocyte-specific protein 1 links TNF receptor-associated factor 1 to survival signaling downstream of 4-1BB in T cells. J Leukoc Biol. 2013 May;93(5):713-21
All references(48)

Other
accession IDs

MGD-MRK-11892, MGD-MRK-11893