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Lrpap1 Gene Detail
Summary
  • Symbol
    Lrpap1
  • Name
    low density lipoprotein receptor-related protein associated protein 1
  • Synonyms
    RAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:96829
    NCBI Gene: 16976
Location & Maps
more
  • Sequence Map
    Chr5:35091501-35105766 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14266 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    LRPAP1, LDL receptor related protein associated protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRPAP1, LDL receptor related protein associated protein 1
    Orthology source: HomoloGene
  • Synonyms
    A2MRAP, A2RAP, alpha-2-MRAP, HBP44, MRAP, MYP23, RAP
  • Links
    NCBI Gene ID: 4043
    neXtProt AC: NX_P30533

  • Chr Location
    4p16.3; chr4:3503597-3532497 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human LRPAP1 associations

Human Disease Mouse Models
       Myopia 23, Autosomal Recessive; MYP23   OMIM: 615431
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    32
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    19
  • Radiation induced
    5
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    9 involving Lrpap1
  • Incidental Mutations
Mice homozygous for disruptions in this gene display an essentially normal phenotype. However, subtle abnormalities are seen in behavior, brain function and thyroid function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023232 VEGA Gene Model | MGI Sequence Detail 14266 C57BL/6J ±  kb
transcript OTTMUST00000056253 VEGA | MGI Sequence Detail 2981 Not Applicable  
polypeptide OTTMUSP00000027009 VEGA | MGI Sequence Detail 360 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    115 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000009929 alpha-2-macroglobulin receptor-associated protein
  • InterPro Domains
    IPR010483 Alpha-2-macroglobulin RAP, C-terminal
    IPR009066 Alpha-2-macroglobulin receptor-associated protein, domain 1
Molecular
Reagents
less
  • All nucleic 259
    Genomic 3
    cDNA 256

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-11887, MGI:2140781, MGI:2140964, MGI:2141085, MGI:2141295
References
more
  • Summaries
    All 71
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 6
    Phenotypes 40
  • Earliest
    J:18372 Furukawa T, et al., A heparin binding protein whose expression increases during differentiation of embryonal carcinoma cells to parietal endoderm cells: cDNA cloning and sequence analysis. J Biochem. 1990 Aug;108(2):297-302
  • Latest
    J:210621 Gu H, et al., The role of choroid plexus in IVIG-induced beta-amyloid clearance. Neuroscience. 2014 Jun 13;270:168-76

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory