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Lrpap1
Gene Detail
Symbol

Name
ID
Lrpap1
low density lipoprotein receptor-related protein associated protein 1
MGI:96829
Synonyms
RAP
Feature Type
protein coding gene
Genetic Map
Chromosome 5
18.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr5:35091490-35105766 bp, - strand
From VEGA annotation of GRCm38

  14277 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37612  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LRPAP1
Gene Tree: Lrpap1

Human
homologs
LRPAP1, low density lipoprotein receptor-related protein associated protein 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4043
neXtProt AC: NX_P30533

Human Synonyms: A2MRAP, A2RAP, alpha-2-MRAP, HBP44, MRAP, MYP23, RAP

Human Chr (Location): 4p16.3; chr4:3503597-3532497 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LRPAP1

Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Chemically induced (ENU)(1) Gene trapped(19) Radiation induced(5) Targeted(4)
Genomic Mutations involving Lrpap1 (6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display an essentially normal phenotype. However, subtle abnormalities are seen in behavior, brain function and thyroid function.
 
Mutations Annotated to Human Diseases (4)    Phenotype Images(4)
Interactions
Lrpap1 interacts with 190 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (191)    Tissues (58)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 161
Northern blot 30
cDNA source data(255)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lrpap1 ; ZFIN lrpap1    NEW 
Molecular
reagents
All nucleic(259) Genomic(3) cDNA(256)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000023232 (Evidence)
Ensembl Gene Model ENSMUSG00000029103 (Evidence)
Entrez Gene 16976 (Evidence)
UniGene 277661
DFCI TC1573097
DoTS DT.55107344, DT.87043675, DT.94411679
NIA Mouse Gene Index U026104
Consensus CDS Project CCDS19225.1
International Mouse Phenotyping Consortium Status Lrpap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023232 VEGA Gene Model | MGI Sequence Detail 14277 C57BL/6J ±  kb
transcript OTTMUST00000056253 VEGA | MGI Sequence Detail 2992 Not Applicable 
polypeptide OTTMUSP00000027009 VEGA | MGI Sequence Detail 360 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(2) UniProt(12)
Polymorphisms
RFLP(1) : SNPs within 2kb(115 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010483 Alpha-2-macroglobulin RAP, C-terminal
InterPro IPR009066 Alpha-2-macroglobulin receptor-associated protein, domain 1
Protein Ontology PR:000009929 alpha-2-macroglobulin receptor-associated protein
References
(Earliest) J:18372 Furukawa T, et al., A heparin binding protein whose expression increases during differentiation of embryonal carcinoma cells to parietal endoderm cells: cDNA cloning and sequence analysis. J Biochem. 1990 Aug;108(2):297-302
(Latest) J:210621 Gu H, et al., The role of choroid plexus in IVIG-induced beta-amyloid clearance. Neuroscience. 2014 Jun 13;270:168-76
All references(74)
Other
accession IDs
MGD-MRK-11887, MGI:2140781, MGI:2140964, MGI:2141085, MGI:2141295

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory