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Lrpap1
Gene Detail
 Symbol
Name
ID
Lrpap1
low density lipoprotein receptor-related protein associated protein 1
MGI:96829
Synonyms RAP
Feature Type protein coding gene
Genetic Map
Chromosome 5
18.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr5:35091490-35105766 bp, - strand
From VEGA annotation of GRCm38

  14277 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37612  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lrpap1

Human
homologs
Human Homolog LRPAP1, low density lipoprotein receptor-related protein associated protein 1
NCBI Gene ID 4043
neXtProt AC  NX_P30533
Human Synonyms  A2MRAP, A2RAP, alpha-2-MRAP, HBP44, MRAP, MYP23, RAP
Human Chr (Location)  4p16.3; chr4:3503597-3532497 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human LRPAP1
Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Chemically induced (ENU)(1) Gene trapped(19) Radiation induced(4) Targeted(4)
Genomic Mutations involving Lrpap1 (5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display an essentially normal phenotype. However, subtle abnormalities are seen in behavior, brain function and thyroid function.
 
Alleles Annotated to Human Diseases(4)   
Interactions
Lrpap1 interacts with 191 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process extracellular negative regulation of signal transduction, negative regulation of beta-amyloid clearance, ...
Component cytoplasm, endoplasmic reticulum, ...
Function heparin binding, lipase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (191)    Tissues (58)    Images (47)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 161
Northern blot 30
cDNA source data(255)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(259) Genomic(3) cDNA(256)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000023232 (Evidence)
Ensembl Gene ModelENSMUSG00000029103 (Evidence)
Entrez Gene16976 (Evidence)
UniGene277661
DFCITC1573097
DoTSDT.55107344, DT.87043675, DT.94411679
NIA Mouse Gene IndexU026104
Consensus CDS ProjectCCDS19225.1
International Mouse Knockout Project StatusLrpap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023232 VEGA Gene Model | MGI Sequence Detail 14277 C57BL/6J ±  kb
transcript OTTMUST00000056253 VEGA | MGI Sequence Detail 2992 Not Applicable 
polypeptide OTTMUSP00000027009 VEGA | MGI Sequence Detail 360 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(2) UniProt(12)
Polymorphisms RFLP(1) : SNPs within 2kb(115 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010483 Alpha-2-macroglobulin RAP, C-terminal
InterPro IPR009066 Alpha-2-macroglobulin receptor-associated protein, domain 1
Protein Ontology PR:000009929 alpha-2-macroglobulin receptor-associated protein
References (Earliest) J:18372 Furukawa T, et al., A heparin binding protein whose expression increases during differentiation of embryonal carcinoma cells to parietal endoderm cells: cDNA cloning and sequence analysis. J Biochem. 1990 Aug;108(2):297-302
(Latest) J:210621 Gu H, et al., The role of choroid plexus in IVIG-induced beta-amyloid clearance. Neuroscience. 2014 Jun 13;270:168-76
All references(75)
Other
accession IDs
MGD-MRK-11887, MGI:2140781, MGI:2140964, MGI:2141085, MGI:2141295

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory