Lrpap1
Gene Detail

Symbol Name ID

Lrpap1 low density lipoprotein receptor-related protein associated protein 1 MGI:96829

Synonyms

RAP

Feature Type

protein coding gene

Genetic Map

Chromosome 5

18.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr5:35091490-35105766 bp, - strand From VEGA annotation of GRCm38   14277 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37612  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lrpap1

Human homologs

Human Homolog		LRPAP1, low density lipoprotein receptor-related protein associated protein 1
NCBI Gene ID		4043
neXtProt AC		NX_P30533
Human Synonyms		A2MRAP, A2RAP, HBP44, MRAP, RAP
Human Chr (Location)		4p16.3; chr4:3505324-3534224 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(23) : Targeted(4) Gene trapped(19)
 

Mice homozygous for disruptions in this gene display an essentially normal phenotype. However, subtle abnormalities are seen in behavior, brain function and thyroid function.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	extracellular negative regulation of signal transduction, negative regulation of beta-amyloid clearance, ...
Component	cytoplasm, endoplasmic reticulum, ...
Function	heparin binding, lipase binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (191)    Tissues (58)    Images (47)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	161
Northern blot	30

cDNA source data(254)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(258) Genomic(3) cDNA(255)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000023232 (Evidence)
Ensembl Gene Model	ENSMUSG00000029103 (Evidence)
Entrez Gene	16976 (Evidence)
UniGene	277661
DFCI	TC1573097
DoTS	DT.55107344, DT.87043675, DT.94411679
NIA Mouse Gene Index	U026104
Consensus CDS Project	CCDS19225.1
International Mouse Knockout Project Status	Lrpap1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023232	VEGA Gene Model | MGI Sequence Detail	14277	C57BL/6J
transcript	OTTMUST00000056253	VEGA | MGI Sequence Detail	2992	Not Applicable
polypeptide	OTTMUSP00000027009	VEGA | MGI Sequence Detail	360	Not Applicable

All sequences(71) RefSeq(2) UniProt(12)

Polymorphisms

RFLP(1) : SNPs within 2kb(115 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR010483	Alpha-2-macroglobulin RAP, C-terminal
InterPro	IPR009066	Alpha-2-macroglobulin receptor-associated protein, domain 1
Protein Ontology	PR:000009929	alpha-2-macroglobulin receptor-associated protein

References

(Earliest) J:18372 Furukawa T, et al., A heparin binding protein whose expression increases during differentiation of embryonal carcinoma cells to parietal endoderm cells: cDNA cloning and sequence analysis. J Biochem. 1990 Aug;108(2):297-302
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(72)

Other accession IDs

MGD-MRK-11887, MGI:2140781, MGI:2140964, MGI:2141085, MGI:2141295