About   Help   FAQ
Selenbp1 Gene Detail
Summary
  • Symbol
    Selenbp1
  • Name
    selenium binding protein 1
  • Synonyms
    Lp56, Lpsb
  • Feature Type
    protein coding gene
  • IDs
    MGI:96825
    NCBI Gene: 20341
  • Gene Overview
    MyGene.info: SELENBP1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:94933083-94944758 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.74 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    13
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96825
protein coding gene Chr3:94933056-94944758 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0027519
protein coding gene Chr3:92652293-92672954 (+)
AKR/J MGP_AKRJ_G0027483
protein coding gene Chr3:94496137-94545401 (+)
BALB/cJ MGP_BALBcJ_G0027528
protein coding gene Chr3:92129604-92130982 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0027980
protein coding gene Chr3:99159372-99170483 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0026714
protein coding gene Chr3:94372569-94383936 (+)
CBA/J MGP_CBAJ_G0027242
protein coding gene Chr3:102733678-102768587 (+)
DBA/2J MGP_DBA2J_G0027380
protein coding gene Chr3:91945485-91965410 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0027487
protein coding gene Chr3:96619051-96638922 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0028031
protein coding gene Chr3:94187737-94195891 (+)
PWK/PhJ MGP_PWKPhJ_G0026439
protein coding gene Chr3:91587098-91608938 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026263
protein coding gene Chr3:92709972-92756330 (+)
WSB/EiJ MGP_WSBEiJ_G0026797
protein coding gene Chr3:94841919-94852780 (+)



Homology
more
  • Human Ortholog
    SELENBP1, selenium binding protein 1
  • Vertebrate Orthologs
    14
  • Human Ortholog
    SELENBP1, selenium binding protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EHMTO, HEL-S-134P, hSBP, LPSB, MTO, SBP56, SP56
  • Links
    NCBI Gene ID: 8991
    neXtProt AC: NX_Q13228
    UniProt: Q13228

  • Chr Location
    1q21.3; chr1:151364302-151372734 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit sex-specific changes in organ weights. Mice homozygous for a different allele lack methanethiol oxidase activity and exhibit an increase in dimethylsulfide and dimethyl-sulfone serum levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20341 NCBI Gene Model | MGI Sequence Detail 11676 C57BL/6J ±  kb
    transcript NM_009150 RefSeq | MGI Sequence Detail 1685 C57BL/6  
    polypeptide P17563 UniProt | EBI | MGI Sequence Detail 472 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 207
      Genomic 1
      cDNA 203
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11868, MGD-MRK-11880
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:10796 Bansal MP, et al., DNA sequencing of a mouse liver protein that binds selenium: implications for selenium's mechanism of action in cancer prevention. Carcinogenesis. 1990 Nov;11(11):2071-3
    • Latest
      J:255748 Pol A, et al., Mutations in SELENBP1, encoding a novel human methanethiol oxidase, cause extraoral halitosis. Nat Genet. 2018 Jan;50(1):120-129

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/11/2019
    MGI 6.14
    The Jackson Laboratory