About   Help   FAQ
Anxa1 Gene Detail
Summary
  • Symbol
    Anxa1
  • Name
    annexin A1
  • Synonyms
    Anx-1, Anx-A1, C430014K04Rik, Lpc-1, Lpc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96819
    NCBI Gene: 16952
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:20350798-20368035 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 13.83 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • SNPs within 2kb
    852 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96819
 protein coding gene Chr19:20350792-20368308 (-)
129S1/SvImJ ENSMUSG00200020273
 protein coding gene Chr19:17055631-17073037 (-)
A/J ENSMUSG00195015987
 protein coding gene Chr19:17224346-17241768 (-)
AKR/J ENSMUSG00220010518
 protein coding gene Chr19:17190387-17207946 (-)
BALB/cJ ENSMUSG00180017848
 protein coding gene Chr19:17576557-17594063 (-)
C3H/HeJ ENSMUSG00175003420
 protein coding gene Chr19:16925621-16943021 (-)
C57BL/6NJ ENSMUSG00215015700
 protein coding gene Chr19:16957834-16975352 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022809
 protein coding gene Chr19:17673119-17690512 (-)
CAST/EiJ ENSTCUG00005008130
 protein coding gene Chr19:16815771-16833144 (-)
CBA/J ENSMUSG00210012666
 protein coding gene Chr19:17166990-17184416 (-)
DBA/2J ENSMUSG00185013266
 protein coding gene Chr19:17556098-17573502 (-)
FVB/NJ ENSMUSG00205003430
 protein coding gene Chr19:16987292-17004833 (-)
JF1/MsJ ENSUMUG00000027851
 protein coding gene Chr19:17797258-17814599 (-)
LP/J ENSMUSG00230015844
 protein coding gene Chr19:18410653-18428053 (-)
NOD/ShiLtJ ENSMUSG00190018878
 protein coding gene Chr19:16944423-16961923 (-)
NZO/HlLtJ ENSMUSG00225034085
 protein coding gene Chr19:22166209-22183456 (-)
PWK/PhJ ENSLUMG00010008354
 protein coding gene Chr19:17120380-17137759 (-)
SPRET/EiJ ENSMSPG00010017944
 protein coding gene Chr19:17127136-17144828 (-)
WSB/EiJ ENSIUOG00005006740
 protein coding gene Chr19:16681999-16699524 (-)



Homology
more
  • Human Ortholog
    ANXA1, annexin A1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANXA1, annexin A1
  • Synonyms
    ANX1, LPC1
  • Links
    NCBI Gene ID: 301
    UniProt: P04083

  • Chr Location
    9q21.13; chr9:73148874-73170629 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ANXA1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    52 phenotypes from 2 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    1 images
    82 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in increased inflammatory response and decreased macrophage activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    182
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    803
  • Tissues
    62
  • cDNA Data
    332
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16952 NCBI Gene Model | MGI Sequence Detail 17238 C57BL/6J ±  kb
    transcript NM_010730 RefSeq | MGI Sequence Detail 1395 ZRU/MplStud  
    polypeptide P10107 UniProt | EBI | MGI Sequence Detail 346 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 343
      Genomic 3
      cDNA 333
      Primer pair 5
      Other 2
      Antibodies 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11869, MGD-MRK-11870, MGI:2442613
    References
    more
    • Summaries
      All 203
      Developmental Gene Expression 19
      Gene Ontology 25
      Phenotypes 82
    • Earliest
      J:9543 Sakata T, et al., Mouse lipocortin I cDNA. Nucleic Acids Res. 1988 Dec 23;16(24):11818
    • Latest
      J:388928 Adelizzi E, et al., Ectodermal loss of ARHGAP29 alters epithelial morphology and disrupts murine palatogenesis. Development. 2026 Jun 15;153(12):dev205636
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory