Anxa1
Gene Detail

Symbol

Name
ID

Anxa1
annexin A1
MGI:96819

Synonyms

Anx-1, Anx-A1, C430014K04Rik, Lpc1, Lpc-1

Feature Type

protein coding gene

Genetic Map

Chromosome 19
13.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)

Sequence Map

Chr19:20373428-20390944 bp, - strand From VEGA annotation of GRCm38   17517 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:563  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Anxa1

Human
homologs

Human Homolog		ANXA1, annexin A1
NCBI Gene ID		301
neXtProt AC		NX_P04083
Human Synonyms		ANX1, LPC1
Human Chr (Location)		9q21.13; chr9:73151865-73170391 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mutations in this gene result in increased inflammatory response and decreased macrophage activity.

 
Phenotype Images(1)

Interactions

Anxa1 interacts with 65 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (64 annotations)

Process	alpha-beta T cell differentiation, arachidonic acid secretion, ...
Component	cell projection, cell surface, ...
Function	annealing helicase activity, calcium-dependent phospholipid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)

Data Summary: Results (171)    Tissues (45)    Images (38)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	169
RT-PCR	2

cDNA source data(330)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(336) Genomic(3) cDNA(330) Primer pair(3)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000035986 (Evidence)
Ensembl Gene Model	ENSMUSG00000024659 (Evidence)
Entrez Gene	16952 (Evidence)
UniGene	248360
DFCI	TC1573220, TC1598724
DoTS	DT.101364535, DT.101384298, DT.536818
NIA Mouse Gene Index	U038902
Consensus CDS Project	CCDS29692.1
International Mouse Knockout Project Status	Anxa1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035986	VEGA Gene Model | MGI Sequence Detail	17517	C57BL/6J
transcript	OTTMUST00000092342	VEGA | MGI Sequence Detail	1674	Not Applicable
polypeptide	OTTMUSP00000051013	VEGA | MGI Sequence Detail	346	Not Applicable

All sequences(72) RefSeq(2) UniProt(11)

Polymorphisms

All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(385 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001464	Annexin
InterPro	IPR018502	Annexin repeat
InterPro	IPR018252	Annexin repeat, conserved site
InterPro	IPR002388	Annexin, type I
Protein Ontology	PR:000004071	annexin A1

References

(Earliest) J:9543 Sakata T, et al., Mouse lipocortin I cDNA. Nucleic Acids Res. 1988 Dec 23;16(24):11818
(Latest) J:215552 Machado ID, et al., Alterations in the profile of blood neutrophil membrane receptors caused by in vivo adrenocorticotrophic hormone actions. Am J Physiol Endocrinol Metab. 2014 Nov 1;307(9):E754-63
All references(110)

Other
accession IDs

MGD-MRK-11869, MGD-MRK-11870, MGI:2442613