Anxa1
Gene Detail

Symbol Name ID

Anxa1 annexin A1 MGI:96819

Synonyms

Anx-1, Anx-A1, C430014K04Rik, Lpc1, Lpc-1

Feature Type

protein coding gene

Genetic Map

Chromosome 19

13.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)

Sequence Map

Chr19:20373428-20390944 bp, - strand From VEGA annotation of GRCm38   17517 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:563  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Anxa1

Human homologs

Human Homolog		ANXA1, annexin A1
NCBI Gene ID		301
neXtProt AC		NX_P04083
Human Synonyms		ANX1, LPC1
Human Chr (Location)		9q21.13; chr9:75766721-75785309 (+)  GRCh37.p13

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mutations in this gene result in increased inflammatory response and decreased macrophage activity.

 

Gene Ontology (GO) classifications

All GO classifications: (59 annotations)

Process	alpha-beta T cell differentiation, arachidonic acid secretion, ...
Component	cell projection, cilium, ...
Function	annealing helicase activity, calcium-dependent phospholipid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)

Data Summary: Results (171)    Tissues (45)    Images (38)
Theiler Stages: 19, 22, 23, 28

Assay Type	Results
RNA in situ	169
RT-PCR	2

cDNA source data(330)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(336) Genomic(3) cDNA(330) Primer pair(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000035986 (Evidence)
Ensembl Gene Model	ENSMUSG00000024659 (Evidence)
Entrez Gene	16952 (Evidence)
UniGene	248360
DFCI	TC1573220, TC1598724
DoTS	DT.101364535, DT.101384298, DT.536818
NIA Mouse Gene Index	U038902
Consensus CDS Project	CCDS29692.1
International Mouse Knockout Project Status	Anxa1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035986	VEGA Gene Model | MGI Sequence Detail	17517	C57BL/6J
transcript	OTTMUST00000092342	VEGA | MGI Sequence Detail	1674	Not Applicable
polypeptide	OTTMUSP00000051013	VEGA | MGI Sequence Detail	346	Not Applicable

All sequences(67) RefSeq(2) UniProt(6)

Polymorphisms

All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(385 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR001464	Annexin
InterPro	IPR018502	Annexin repeat
InterPro	IPR018252	Annexin repeat, conserved site
InterPro	IPR002388	Annexin, type I
Protein Ontology	PR:000004071	annexin A1

References

(Earliest) J:9543 Sakata T, et al., Mouse lipocortin I cDNA. Nucleic Acids Res. 1988 Dec 23;16(24):11818
(Latest) J:204762 Girol AP, et al., Anti-inflammatory mechanisms of the annexin A1 protein and its mimetic peptide Ac2-26 in models of ocular inflammation in vivo and in vitro. J Immunol. 2013 Jun 1;190(11):5689-701
All references(107)

Other accession IDs

MGD-MRK-11869, MGD-MRK-11870, MGI:2442613