Anxa1 MGI Mouse Gene Detail - MGI:96819

Anxa1 Gene Detail

Symbol

Anxa1
Name

annexin A1
Synonyms

Anx-1, Anx-A1, C430014K04Rik, Lpc1, Lpc-1

Feature Type

protein coding gene
IDs

MGI:96819
NCBI Gene: 16952
Gene Overview

MyGene.info: ANXA1

Sequence Map

Chr19:20373428-20390944 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

17517 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 13.83 cM
Mapping Data

20 experiments

Human Ortholog

ANXA1, annexin A1

Vertebrate Orthologs

10

Human Ortholog

ANXA1, annexin A1
Orthology source: HomoloGene, HGNC
Synonyms

ANX1, LPC1
Links

HGNC:533

NCBI Gene ID: 301

neXtProt AC: NX_P04083
Chr Location

9q21.13; chr9:73151731-73170393 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 563
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: ANXA1
Gene Tree

Anxa1

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Phenotype Summary

37 phenotypes from 1 allele in 5 genetic backgrounds
2 phenotypes from multigenic genotypes
1 images
44 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Targeted

3
Incidental Mutations

Mutagenetix , APF

Mutations in this gene result in increased inflammatory response and decreased macrophage activity.

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All GO Annotations

98
GO References

13

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

171
Tissues

45
cDNA Data

330
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

GEISHA ANXA1

Xenbase anxa1

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Anxa1 interacts with 64 markers (Mir1a-1, Mir1a-2, Mir7-2, ...) View All

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All Sequences

50
RefSeq

2
UniProt

6
CCDS

CCDS29692.1
UniGene

248360

			Length	Strain/Species	Flank
genomic	OTTMUSG00000035986	VEGA Gene Model \| MGI Sequence Detail	17517	C57BL/6J	± kb
transcript	OTTMUST00000092342	VEGA \| MGI Sequence Detail	1674	Not Applicable
polypeptide	OTTMUSP00000051013	VEGA \| MGI Sequence Detail	346	Not Applicable

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SNPs within 2kb

380 from dbSNP Build 142

PCR

2
RFLP

1

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UniProt

6 Sequences
Protein Ontology

PR:000004071 annexin A1
InterPro Domains

IPR001464 Annexin

IPR018502 Annexin repeat

IPR018252 Annexin repeat, conserved site

IPR002388 Annexin, type I

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All nucleic 336

Genomic 3

cDNA 330

Primer pair 3

Microarray probesets 4

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MGD-MRK-11869, MGD-MRK-11870, MGI:2442613

Summaries

All 113

Developmental Gene Expression 7

Gene Ontology 13

Phenotypes 44
Earliest

J:9543 Sakata T, et al., Mouse lipocortin I cDNA. Nucleic Acids Res. 1988 Dec 23;16(24):11818
Latest

J:234129 Headland SE, et al., Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. Sci Transl Med. 2015 Nov 25;7(315):315ra190

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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