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Anxa1 Gene Detail
Summary
  • Symbol
    Anxa1
  • Name
    annexin A1
  • Synonyms
    Anx-1, Anx-A1, C430014K04Rik, Lpc1, Lpc-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96819
    NCBI Gene: 16952
  • Gene Overview
    MyGene.info: ANXA1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr19:20373428-20390944 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      17517 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 13.83 cM
  • Mapping Data
    20 experiments
Homology
more
  • Human Ortholog
    ANXA1, annexin A1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ANXA1, annexin A1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ANX1, LPC1
  • Links
    NCBI Gene ID: 301
    neXtProt AC: NX_P04083
    UniProt: P04083

  • Chr Location
    9q21.13; chr9:73151731-73170393 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 563
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ANXA1
  • Gene Tree
    Anxa1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 1 allele in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    1 images
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations in this gene result in increased inflammatory response and decreased macrophage activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    153
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    196
  • Tissues
    56
  • cDNA Data
    332
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000035986 VEGA Gene Model | MGI Sequence Detail 17517 C57BL/6J ±  kb
    transcript OTTMUST00000092342 VEGA | MGI Sequence Detail 1674 Not Applicable  
    polypeptide OTTMUSP00000051013 VEGA | MGI Sequence Detail 346 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      380 from dbSNP Build 142
    • PCR
      2
    • RFLP
      1
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 339
      Genomic 3
      cDNA 333
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11869, MGD-MRK-11870, MGI:2442613
    References
    more
    • Summaries
      All 137
      Developmental Gene Expression 8
      Gene Ontology 14
      Phenotypes 53
    • Earliest
      J:9543 Sakata T, et al., Mouse lipocortin I cDNA. Nucleic Acids Res. 1988 Dec 23;16(24):11818
    • Latest
      J:256070 Verma SK, et al., Cell-surface phosphatidylserine regulates osteoclast precursor fusion. J Biol Chem. 2018 Jan 5;293(1):254-270
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory