Anxa1 MGI Mouse Gene Detail - MGI:96819

Symbol

Anxa1
Name

annexin A1
Synonyms

Anx-1, Anx-A1, C430014K04Rik, Lpc1, Lpc-1

Feature Type

protein coding gene
IDs

MGI:96819
NCBI Gene: 16952
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr19:20350798-20368035 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 13.83 cM
Mapping Data

20 experiments

SNPs within 2kb

358 from dbSNP Build 142
Strain Annotations

18
PCR

2
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96819	protein coding gene	Chr19:20350792-20368308 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024972	protein coding gene	Chr19:18358676-18377284 (-)
A/J	MGP_AJ_G0024949	protein coding gene	Chr19:17366088-17383165 (-)
AKR/J	MGP_AKRJ_G0024919	protein coding gene	Chr19:17999580-18022244 (-)
BALB/cJ	MGP_BALBcJ_G0024948	protein coding gene	Chr19:17367696-17385618 (-)
C3H/HeJ	MGP_C3HHeJ_G0024706	protein coding gene	Chr19:17983859-18000863 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025390	protein coding gene	Chr19:19001423-19019642 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022809	protein coding gene	Chr19:17673119-17690512 (-)
CAST/EiJ	MGP_CASTEiJ_G0024174	protein coding gene	Chr19:17627896-17648561 (-)
CBA/J	MGP_CBAJ_G0024684	protein coding gene	Chr19:19749677-19771478 (-)
DBA/2J	MGP_DBA2J_G0024816	protein coding gene	Chr19:17372395-17389811 (-)
FVB/NJ	MGP_FVBNJ_G0024777	protein coding gene	Chr19:17240719-17258375 (-)
LP/J	MGP_LPJ_G0024900	protein coding gene	Chr19:18326882-18343954 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024804	protein coding gene	Chr19:19872720-19905671 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025445	protein coding gene	Chr19:17975820-17994391 (-)
PWK/PhJ	MGP_PWKPhJ_G0023923	protein coding gene	Chr19:16911173-16928605 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023728	protein coding gene	Chr19:17255335-17274204 (-)
WSB/EiJ	MGP_WSBEiJ_G0024242	protein coding gene	Chr19:18018745-18038192 (-)

Human Ortholog

ANXA1, annexin A1

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ANXA1, annexin A1
Synonyms

ANX1, LPC1
Links

HGNC:533

NCBI Gene ID: 301

neXtProt AC: NX_P04083

UniProt: P04083
Chr Location

9q21.13; chr9:73151731-73170393 (+) GRCh38.p7

Alliance of Genome Resources

Anxa1 stringent orthology
1 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: ANXA1
Gene Tree

Anxa1

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Phenotype Summary

37 phenotypes from 1 allele in 5 genetic backgrounds
2 phenotypes from multigenic genotypes
1 images
67 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutations in this gene result in increased inflammatory response and decreased macrophage activity.

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All GO Annotations

145
GO References

19

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

869
Tissues

57
cDNA Data

332
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ANXA1

Xenbase anxa1.1, anxa1.2, anxa1.3

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Anxa1 interacts with 64 markers (Mir1a-1, Mir1a-2, Mir7-2, ...) View All

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All Sequences

63
RefSeq

2
UniProt

7
CCDS

CCDS29692.1

Ensembl

ENSMUSG00000024659 (Evidence)
NCBI Gene

16952

			Length	Strain/Species	Flank
genomic	16952	NCBI Gene Model \| MGI Sequence Detail	17238	C57BL/6J	± kb
transcript	NM_010730	RefSeq \| MGI Sequence Detail	1395	C57BL/6
polypeptide	P10107	UniProt \| EBI \| MGI Sequence Detail	346	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000004071 annexin A1

(term hierarchy)
InterPro Domains

IPR001464 Annexin

IPR002388 Annexin A1

IPR018502 Annexin repeat

IPR018252 Annexin repeat, conserved site

IPR037104 Annexin superfamily

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All nucleic 341

Genomic 3

cDNA 333

Primer pair 4

Other 1

Microarray probesets 4

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MGD-MRK-11869, MGD-MRK-11870, MGI:2442613

Summaries

All 165

Developmental Gene Expression 13

Gene Ontology 19

Phenotypes 67
Earliest

J:9543 Sakata T, et al., Mouse lipocortin I cDNA. Nucleic Acids Res. 1988 Dec 23;16(24):11818
Latest

J:322895 Costa VV, et al., Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease. Elife. 2022 Mar 16;11:e73853

TSS for Anxa1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158560	Chr19:20368360-20368374 (-)	-332 bp
Tssr158559	Chr19:20368029-20368043 (-)	-1 bp
Tssr158558	Chr19:20362995-20362999 (-)	5,038 bp
Tssr158557	Chr19:20361895-20361924 (-)	6,125 bp
Tssr158556	Chr19:20360250-20360350 (-)	7,735 bp
Tssr158555	Chr19:20357037-20357078 (-)	10,977 bp
Tssr158554	Chr19:20355775-20355835 (-)	12,230 bp
Tssr158553	Chr19:20352635-20352719 (-)	15,358 bp
Tssr158552	Chr19:20351069-20351103 (-)	16,949 bp
Tssr158551	Chr19:20350924-20351065 (-)	17,040 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/28/2022 MGI 6.20