Anxa1 MGI Mouse Gene Detail - MGI:96819

Anxa1 Gene Detail

Symbol

Anxa1
Name

annexin A1
Synonyms

Anx-1, Anx-A1, C430014K04Rik, Lpc1, Lpc-1

Feature Type

protein coding gene
IDs

MGI:96819
NCBI Gene: 16952
Gene Overview

MyGene.info: ANXA1
Alliance

gene page

Sequence Map

Chr19:20373428-20390944 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

17517 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 13.83 cM
Mapping Data

20 experiments

Human Ortholog

ANXA1, annexin A1

Vertebrate Orthologs

10

Human Ortholog

ANXA1, annexin A1
Orthology source: HomoloGene, HGNC
Synonyms

ANX1, LPC1
Links

HGNC:533

NCBI Gene ID: 301

neXtProt AC: NX_P04083

UniProt: P04083
Chr Location

9q21.13; chr9:73151731-73170393 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 563
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ANXA1
Gene Tree

Anxa1

less

Phenotype Summary

37 phenotypes from 1 allele in 5 genetic backgrounds
2 phenotypes from multigenic genotypes
1 images
46 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

9 strains or lines available

Mutations in this gene result in increased inflammatory response and decreased macrophage activity.

less

All GO Annotations

99
GO References

13

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

196
Tissues

56
cDNA Data

330
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ANXA1

less

Anxa1 interacts with 64 markers (Mir1a-1, Mir1a-2, Mir7-2, ...) View All

less

All Sequences

50
RefSeq

2
UniProt

6
CCDS

CCDS29692.1
UniGene

248360

			Length	Strain/Species	Flank
genomic	OTTMUSG00000035986	VEGA Gene Model \| MGI Sequence Detail	17517	C57BL/6J	± kb
transcript	OTTMUST00000092342	VEGA \| MGI Sequence Detail	1674	Not Applicable
polypeptide	OTTMUSP00000051013	VEGA \| MGI Sequence Detail	346	Not Applicable

less

SNPs within 2kb

380 from dbSNP Build 142

PCR

2
RFLP

1

less

UniProt

6 Sequences
Protein Ontology

PR:000004071 annexin A1

(term hierarchy)
InterPro Domains

IPR001464 Annexin

IPR002388 Annexin A1

IPR018502 Annexin repeat

IPR018252 Annexin repeat, conserved site

less

All nucleic 337

Genomic 3

cDNA 331

Primer pair 3

Microarray probesets 4

less

MGD-MRK-11869, MGD-MRK-11870, MGI:2442613

Summaries

All 116

Developmental Gene Expression 7

Gene Ontology 13

Phenotypes 46
Earliest

J:9543 Sakata T, et al., Mouse lipocortin I cDNA. Nucleic Acids Res. 1988 Dec 23;16(24):11818
Latest

J:242001 A-Gonzalez N, et al., Phagocytosis imprints heterogeneity in tissue-resident macrophages. J Exp Med. 2017 May 01;214(5):1281-1296

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/10/2017 MGI 6.10