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Anxa1 Gene Detail
Summary
  • Symbol
    Anxa1
  • Name
    annexin A1
  • Synonyms
    Anx-1, Anx-A1, C430014K04Rik, Lpc1, Lpc-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96819
    NCBI Gene: 16952
  • Gene Overview
    MyGene.info: ANXA1
Location & Maps
more
  • Sequence Map
    Chr19:20373428-20390944 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      17517 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 13.83 cM
  • Mapping Data
    20 experiments
Homology
more
  • Human Ortholog
    ANXA1, annexin A1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ANXA1, annexin A1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ANX1, LPC1
  • Links
    NCBI Gene ID: 301
    neXtProt AC: NX_P04083
    UniProt: P04083

  • Chr Location
    9q21.13; chr9:73151731-73170393 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 563
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ANXA1
  • Gene Tree
    Anxa1
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 1 allele in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    1 images
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in increased inflammatory response and decreased macrophage activity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    99
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    196
  • Tissues
    56
  • cDNA Data
    330
  • Literature Summary
    7
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035986 VEGA Gene Model | MGI Sequence Detail 17517 C57BL/6J ±  kb
transcript OTTMUST00000092342 VEGA | MGI Sequence Detail 1674 Not Applicable  
polypeptide OTTMUSP00000051013 VEGA | MGI Sequence Detail 346 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    380 from dbSNP Build 142
  • PCR
    2
  • RFLP
    1
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 337
    Genomic 3
    cDNA 331
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11869, MGD-MRK-11870, MGI:2442613
References
more
  • Summaries
    All 114
    Developmental Gene Expression 7
    Gene Ontology 13
    Phenotypes 45
  • Earliest
    J:9543 Sakata T, et al., Mouse lipocortin I cDNA. Nucleic Acids Res. 1988 Dec 23;16(24):11818
  • Latest
    J:238758 Park JC, et al., Annexin A1 restores Abeta1-42 -induced blood-brain barrier disruption through the inhibition of RhoA-ROCK signaling pathway. Aging Cell. 2017 Feb;16(1):149-161
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
07/11/2017
MGI 6.10 		The Jackson Laboratory