Lor
Gene Detail

Symbol

Name
ID

Lor
loricrin
MGI:96816

Feature Type

protein coding gene

Genetic Map

Chromosome 3
40.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr3:92080271-92083142 bp, - strand From VEGA annotation of GRCm38   2872 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

Protein SuperFamily: loricrin
Gene Tree: Lor

Mutations,
alleles, and
phenotypes

All mutations/alleles(3) : Targeted(3)
 

Mice homozygous for disruptions in this gene are runted at birth, have a translucent skin and skin skin barrier defect. The morphological skin phenotype disappears after 4-5 days.

 
Phenotype Images(3)

Interactions

Lor interacts with 65 markers (Mir10a, Mir17, Mir20b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (7 annotations)

Process	keratinization
Component	cornified envelope, cytoplasm, ...
Function	structural constituent of cytoskeleton, structural constituent of epidermis

External Resources: FuncBase

Expression

Literature Summary: (137 records)

Data Summary: Results (41)    Tissues (17)    Images (28)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	29
RNA in situ	12

cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(25) Genomic(3) cDNA(21) Primer pair(1)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000045087 (Evidence)
Ensembl Gene Model	ENSMUSG00000043165 (Evidence)
Entrez Gene	16939 (Evidence)
UniGene	1121
DFCI	TC1579224
DoTS	DT.102534374, DT.40186303
Consensus CDS Project	CCDS17546.1
International Mouse Knockout Project Status	Lor

Sequences

Length	Strain/Species
genomic	OTTMUSG00000045087	VEGA Gene Model | MGI Sequence Detail	2872	C57BL/6J
transcript	OTTMUST00000118473	VEGA | MGI Sequence Detail	1779	Not Applicable
polypeptide	OTTMUSP00000066120	VEGA | MGI Sequence Detail	486	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs within 2kb(1 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
Protein Ontology	PR:000009882	loricrin

References

(Earliest) J:17535 Nischt R, et al., Localization of a novel mRNA in keratinizing epithelia of the mouse: evidence for the sequential activation of differentiation-specific genes. Epithelia. 1987;1(2):165-77
(Latest) J:215827 Richardson RJ, et al., Periderm prevents pathological epithelial adhesions during embryogenesis. J Clin Invest. 2014 Sep 2;124(9):3891-900
All references(174)

Other
accession IDs

MGD-MRK-11864, MGI:2139617, MGI:2140110