Lor
Gene Detail

Symbol Name ID

Lor loricrin MGI:96816

Feature Type

protein coding gene

Genetic Map

Chromosome 3

40.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr3:92080275-92083142 bp, - strand From Ensembl annotation of GRCm38   2868 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68056  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: loricrin
Gene Tree: Lor

Human homologs

Human Homolog		LOR, loricrin
NCBI Gene ID		4014
neXtProt AC		NX_P23490
Human Chr (Location)		1q21; chr1:153232179-153234600 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LOR

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for disruptions in this gene are runted at birth, have a translucent skin and skin skin barrier defect. The morphological skin phenotype disappears after 4-5 days.

 
Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	keratinization, keratinocyte differentiation, ...
Component	cornified envelope, cytoplasmic part, ...
Function	protein binding, bridging, structural constituent of cytoskeleton, ...

External Resources: FuncBase

Expression

Literature Summary: (117 records)
Data Summary: Results (39)    Tissues (16)    Images (28)
Theiler Stages: 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	27
RNA in situ	12

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) Genomic(3) cDNA(20) Primer pair(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000043165 (Evidence)
Entrez Gene	16939 (Evidence)
UniGene	1121
DFCI	TC1579224
DoTS	DT.102534374, DT.40186303
Consensus CDS Project	CCDS17546.1
International Mouse Knockout Project Status	Lor

Sequences

Length	Strain/Species
genomic	ENSMUSG00000043165	Ensembl Gene Model | MGI Sequence Detail	2868	C57BL/6J
transcript	ENSMUST00000058150	Ensembl | MGI Sequence Detail	1775	Not Applicable
polypeptide	ENSMUSP00000052128	Ensembl | MGI Sequence Detail	486	Not Applicable

All sequences(16) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(1 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000009882	loricrin

References

(Earliest) J:17535 Nischt R, et al., Localization of a novel mRNA in keratinizing epithelia of the mouse: evidence for the sequential activation of differentiation-specific genes. Epithelia. 1987;1(2):165-77
(Latest) J:192592 Sotiropoulou PA, et al., BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny. Genes Dev. 2013 Jan 1;27(1):39-51
All references(151)

Other accession IDs

MGD-MRK-11864, MGI:2139617, MGI:2140110