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Lor Gene Detail
Summary
  • Symbol
    Lor
  • Name
    loricrin
  • Feature Type
    protein coding gene
  • IDs
    MGI:96816
    NCBI Gene: 16939
  • Gene Overview
    MyGene.info: LOR
Location & Maps
more
  • Sequence Map
    Chr3:92080271-92083142 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      2872 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.14 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    LOR, loricrin
  • Human Ortholog
    LOR, loricrin
    Orthology source: HGNC
  • Links
    NCBI Gene ID: 4014
    neXtProt AC: NX_P23490

  • Chr Location
    1q21; chr1:153259635-153262125 (+)  GRCh38.p2
  • HCOP
    human homology predictions: LOR
  • Protein SuperFamily
    loricrin
  • Gene Tree
    Lor
Human Diseases
more
  • Diseases
    1 with human LOR associations

Human Disease Mouse Models
       Vohwinkel Syndrome, Variant Form   OMIM: 604117
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    3 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Lor
Mice homozygous for disruptions in this gene are runted at birth, have a translucent skin and skin skin barrier defect. The morphological skin phenotype disappears after 4-5 days.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    7
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    45
  • Tissues
    19
  • cDNA Data
    19
  • Literature Summary
    152
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045087 VEGA Gene Model | MGI Sequence Detail 2872 C57BL/6J ±  kb
transcript OTTMUST00000118473 VEGA | MGI Sequence Detail 1779 Not Applicable  
polypeptide OTTMUSP00000066120 VEGA | MGI Sequence Detail 486 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1 from dbSNP Build 142
  • RFLP
    1
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    Genomic 3
    cDNA 21
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11864, MGI:2139617, MGI:2140110
References
more
  • Summaries
    All 186
    Developmental Gene Expression 152
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:17535 Nischt R, et al., Localization of a novel mRNA in keratinizing epithelia of the mouse: evidence for the sequential activation of differentiation-specific genes. Epithelia. 1987;1(2):165-77
  • Latest
    J:233601 Akinduro O, et al., Constitutive Autophagy and Nucleophagy during Epidermal Differentiation. J Invest Dermatol. 2016 Jul;136(7):1460-70
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory