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Lor
Gene Detail
 Symbol
Name
ID
Lor
loricrin
MGI:96816
Feature Type protein coding gene
Genetic Map
Chromosome 3
40.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr3:92080275-92083142 bp, - strand
From Ensembl annotation of GRCm38

  2868 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: loricrin
Gene Tree: Lor
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
 
Mice homozygous for disruptions in this gene are runted at birth, have a translucent skin and skin skin barrier defect. The morphological skin phenotype disappears after 4-5 days.
 
Phenotype Images(3)
Interactions
Lor interacts with 65 markers (Mir10a, Mir17, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process keratinization
Component cornified envelope, cytoplasm, ...
Function structural constituent of cytoskeleton, structural constituent of epidermis
External Resources: FuncBase
Expression
Literature Summary: (127 records)
Data Summary: Results (41)    Tissues (16)    Images (28)
Theiler Stages: 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 29
RNA in situ 12
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(3) cDNA(21) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000043165 (Evidence)
Entrez Gene16939 (Evidence)
UniGene1121
DFCITC1579224
DoTSDT.102534374, DT.40186303
Consensus CDS ProjectCCDS17546.1
International Mouse Knockout Project StatusLor
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043165 Ensembl Gene Model | MGI Sequence Detail 2868 C57BL/6J ±  kb
transcript ENSMUST00000058150 Ensembl | MGI Sequence Detail 1775 Not Applicable 
polypeptide ENSMUSP00000052128 Ensembl | MGI Sequence Detail 486 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(1 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000009882 loricrin
References (Earliest) J:17535 Nischt R, et al., Localization of a novel mRNA in keratinizing epithelia of the mouse: evidence for the sequential activation of differentiation-specific genes. Epithelia. 1987;1(2):165-77
(Latest) J:206588 Mardaryev AN, et al., p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells. Development. 2014 Jan;141(1):101-11
All references(162)
Other
accession IDs
MGD-MRK-11864, MGI:2139617, MGI:2140110

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory