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Lor Gene Detail
Summary
  • Symbol
    Lor
  • Name
    loricrin
  • Feature Type
    protein coding gene
  • IDs
    MGI:96816
    NCBI Gene: 16939
  • Gene Overview
    MyGene.info: LOR
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:92080271-92083142 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.14 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96816
 protein coding gene Chr3:92080271-92083142 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027485
 protein coding gene Chr3:92500500-92503371 (-)
A/J MGP_AJ_G0027449
 protein coding gene Chr3:89550778-89553649 (-)
AKR/J MGP_AKRJ_G0027414
 protein coding gene Chr3:91701549-91704477 (-)
BALB/cJ MGP_BALBcJ_G0027458
 protein coding gene Chr3:89394257-89397113 (-)
C3H/HeJ MGP_C3HHeJ_G0027200
 protein coding gene Chr3:91914528-91917399 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027904
 protein coding gene Chr3:96036080-96038995 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025255
 protein coding gene Chr3:86243924-86246789 (-)
CAST/EiJ MGP_CASTEiJ_G0026645
 protein coding gene Chr3:91268487-91271359 (-)
CBA/J MGP_CBAJ_G0027175
 protein coding gene Chr3:99312384-99315255 (-)
DBA/2J MGP_DBA2J_G0027312
 protein coding gene Chr3:88915952-88918823 (-)
FVB/NJ MGP_FVBNJ_G0027280
 protein coding gene Chr3:87089315-87092081 (-)
LP/J MGP_LPJ_G0027421
 protein coding gene Chr3:93741024-93743895 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027301
 protein coding gene Chr3:105555263-105558128 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027963
 protein coding gene Chr3:91427999-91430870 (-)
PWK/PhJ MGP_PWKPhJ_G0026379
 protein coding gene Chr3:88855727-88858675 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026198
 protein coding gene Chr3:89778317-89781184 (-)
WSB/EiJ MGP_WSBEiJ_G0026727
 protein coding gene Chr3:91792462-91795333 (-)



Homology
more
  • Human Ortholog
    LOR, loricrin
  • Human Ortholog
    LOR, loricrin
    Orthology source: HGNC
  • Links
    NCBI Gene ID: 4014
    neXtProt AC: NX_P23490
    UniProt: P23490

  • Chr Location
    1q21.3; chr1:153259703-153262124 (+)  GRCh38.p7
  • HCOP
    human homology predictions: LOR
  • Protein SuperFamily
    loricrin
  • Gene Tree
    Lor
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    3 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are runted at birth, have a translucent skin and skin skin barrier defect. The morphological skin phenotype disappears after 4-5 days.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    85
  • Tissues
    34
  • cDNA Data
    20
  • Literature Summary
    183
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16939 NCBI Gene Model | MGI Sequence Detail 2872 C57BL/6J ±  kb
    transcript NM_008508 RefSeq | MGI Sequence Detail 1799 C57BL/6  
    polypeptide P18165 UniProt | EBI | MGI Sequence Detail 486 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 3
      cDNA 22
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11864, MGI:2139617, MGI:2140110
    References
    more
    • Summaries
      All 230
      Developmental Gene Expression 183
      Diseases 1
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:17535 Nischt R, et al., Localization of a novel mRNA in keratinizing epithelia of the mouse: evidence for the sequential activation of differentiation-specific genes. Epithelia. 1987;1(2):165-77
    • Latest
      J:272251 Noguchi S, et al., Beclin 1 regulates recycling endosome and is required for skin development in mice. Commun Biol. 2019;2:37
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/04/2019
    MGI 6.14     		The Jackson Laboratory