Lor MGI Mouse Gene Detail - MGI:96816

Symbol

Lor
Name

loricrin

Feature Type

protein coding gene
IDs

MGI:96816
NCBI Gene: 16939
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr3:91987578-91990449 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 40.14 cM
Mapping Data

7 experiments

SNPs within 2kb

1 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96816	protein coding gene	Chr3:91987578-91990449 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027485	protein coding gene	Chr3:92500500-92503371 (-)
A/J	MGP_AJ_G0027449	protein coding gene	Chr3:89550778-89553649 (-)
AKR/J	MGP_AKRJ_G0027414	protein coding gene	Chr3:91701549-91704477 (-)
BALB/cJ	MGP_BALBcJ_G0027458	protein coding gene	Chr3:89394257-89397113 (-)
C3H/HeJ	MGP_C3HHeJ_G0027200	protein coding gene	Chr3:91914528-91917399 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027904	protein coding gene	Chr3:96036080-96038995 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025255	protein coding gene	Chr3:86243924-86246789 (-)
CAST/EiJ	MGP_CASTEiJ_G0026645	protein coding gene	Chr3:91268487-91271359 (-)
CBA/J	MGP_CBAJ_G0027175	protein coding gene	Chr3:99312384-99315255 (-)
DBA/2J	MGP_DBA2J_G0027312	protein coding gene	Chr3:88915952-88918823 (-)
FVB/NJ	MGP_FVBNJ_G0027280	protein coding gene	Chr3:87089315-87092081 (-)
LP/J	MGP_LPJ_G0027421	protein coding gene	Chr3:93741024-93743895 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027301	protein coding gene	Chr3:105555263-105558128 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027963	protein coding gene	Chr3:91427999-91430870 (-)
PWK/PhJ	MGP_PWKPhJ_G0026379	protein coding gene	Chr3:88855727-88858675 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026198	protein coding gene	Chr3:89778317-89781184 (-)
WSB/EiJ	MGP_WSBEiJ_G0026727	protein coding gene	Chr3:91792462-91795333 (-)

Human Ortholog

LORICRIN, loricrin cornified envelope precursor protein

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LORICRIN, loricrin cornified envelope precursor protein
Synonyms

LOR
Links

HGNC:6663

NCBI Gene ID: 4014

neXtProt AC: NX_P23490

UniProt: P23490
Chr Location

1q21.3; chr1:153259703-153262124 (+) GRCh38.p7

Alliance of Genome Resources

Lor stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: LORICRIN
Gene Tree

Lor

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References

1 with disease annotations

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Phenotype Summary

22 phenotypes from 2 alleles in 2 genetic backgrounds
3 images
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Lor
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene are runted at birth, have a translucent skin and skin skin barrier defect. The morphological skin phenotype disappears after 4-5 days.

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All GO Annotations

10
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

841
Tissues

56
cDNA Data

21
Literature Summary

217

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Lor interacts with 65 markers (Mir10a, Mir17, Mir20b, ...) View All

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All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS17546.1

Ensembl

ENSMUSG00000043165 (Evidence)
NCBI Gene

16939

			Length	Strain/Species	Flank
genomic	16939	NCBI Gene Model \| MGI Sequence Detail	2872	C57BL/6J	± kb
transcript	NM_008508	RefSeq \| MGI Sequence Detail	1777	C57BL/6
polypeptide	P18165	UniProt \| EBI \| MGI Sequence Detail	486	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000009882 loricrin

(term hierarchy)

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All nucleic 34

Genomic 3

cDNA 24

Primer pair 6

Other 1

Microarray probesets 4

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MGD-MRK-11864, MGI:2139617, MGI:2140110

Summaries

All 269

Developmental Gene Expression 217

Diseases 1

Gene Ontology 8

Phenotypes 16
Earliest

J:17535 Nischt R, et al., Localization of a novel mRNA in keratinizing epithelia of the mouse: evidence for the sequential activation of differentiation-specific genes. Epithelia. 1987;1(2):165-77
Latest

J:323229 Rosendahl AH, et al., Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia. J Biol Chem. 2022 Mar 2;298(4):101787

TSS for Lor:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34270	Chr3:91990439-91990454 (-)	2 bp
Tssr34269	Chr3:91988950-91988966 (-)	1,491 bp
Tssr34268	Chr3:91988660-91988673 (-)	1,782 bp
Tssr34267	Chr3:91988220-91988238 (-)	2,220 bp
Tssr34266	Chr3:91987692-91987719 (-)	2,743 bp
Tssr34265	Chr3:91987608-91987654 (-)	2,818 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/28/2022 MGI 6.20