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Mycl
Gene Detail
Symbol

Name
ID
Mycl
v-myc myelocytomatosis viral oncogene homolog, lung carcinoma derived (avian)
MGI:96799
Synonyms
bHLHe38, L-myc, Lmyc1, Lmyc-1, Mycl1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
57.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(40)
Sequence Map
Chr4:122995652-123002485 bp, + strand
From VEGA annotation of GRCm38

  6834 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3921  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MYCL
Protein SuperFamily: myc protein
Gene Tree: Mycl

Human
homologs
MYCL, v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4610
neXtProt AC: NX_P12524

Human Synonyms: bHLHe38, L-Myc, LMYC, MYCL1

Human Chr (Location): 1p34.2; chr1:39895424-39902015 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Genomic Mutations involving Mycl (1)
 
Mice homozygous for a targeted null allele are viable, fertile and apparently healthy with no congenital defects or gross morphological/cellular alterations of the CNS, lung, kidney and GI tract.
 
Interactions
Mycl interacts with 255 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process regulation of auditory receptor cell differentiation, regulation of transcription, DNA-templated
Component nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (397)    Tissues (171)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 309
Northern blot 42
RT-PCR 44
RNase protection 2
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MYCL ; Xenbase mycl ; ZFIN mycla, myclb    NEW 
Molecular
reagents
All nucleic(30) Genomic(6) cDNA(12) Primer pair(5) Other(7)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000008931 (Evidence)
Ensembl Gene Model ENSMUSG00000028654 (Evidence)
Entrez Gene 16918 (Evidence)
DFCI TC1579235, TC1612217
DoTS DT.101378678, DT.528644
NIA Mouse Gene Index U042574
Consensus CDS Project CCDS18606.1
International Mouse Phenotyping Consortium Status Mycl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008931 VEGA Gene Model | MGI Sequence Detail 6834 C57BL/6J ±  kb
transcript OTTMUST00000020287 VEGA | MGI Sequence Detail 3293 Not Applicable 
polypeptide OTTMUSP00000009306 VEGA | MGI Sequence Detail 368 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(7) UniProt(3)
Polymorphisms
All PCR and RFLP(13) : PCR(1) RFLP(12) SNPs within 2kb(18 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR002418 Transcription regulator Myc
InterPro IPR012682 Transcription regulator Myc, N-terminal
Protein Ontology PR:000010810 protein L-Myc-1
References
(Earliest) J:8211 Zimmerman KA, et al., Differential expression of myc family genes during murine development. Nature. 1986 Feb 27-Mar 5;319(6056):780-3
(Latest) J:210103 Huijbers IJ, et al., Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells. EMBO Mol Med. 2014 Feb;6(2):212-25
All references(95)
Other
accession IDs
MGD-MRK-11830, MGD-MRK-11832, MGI:2140581

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory