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Lifr Gene Detail
Summary
  • Symbol
    Lifr
  • Name
    leukemia inhibitory factor receptor
  • Synonyms
    A230075M04Rik, soluble differentiation-stimulating factor receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:96788
    NCBI Gene: 16880
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:7090615-7197489 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      106875 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 3.46 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    LIFR, LIF receptor alpha
  • Vertebrate Orthologs
    11
  • Human Ortholog
    LIFR, LIF receptor alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD118, LIF-R, SJS2, STWS, SWS
  • Links
    NCBI Gene ID: 3977
    neXtProt AC: NX_P42702
    UniProt: P42702

  • Chr Location
    5p13.1; chr5:38474963-38606290 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1735
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LIFR
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 3 alleles in 4 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations die as neonates with reduced numbers of facial and spinal motor neurons, neurons of the nucleus ambiguus, and astrocytes. Mutants also show impaired placentation, severe osteopenia, and low hepatic glycogen stores.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16880 NCBI Gene Model | MGI Sequence Detail 106875 C57BL/6J ±  kb
    transcript NM_001358593 RefSeq | MGI Sequence Detail 9876 C57BL/6  
    polypeptide P42703 UniProt | EBI | MGI Sequence Detail 1092 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      761 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 106
      Genomic 12
      cDNA 87
      Primer pair 4
      Other 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-11808, MGI:2146188, MGI:2442497
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 25
      Gene Ontology 8
      Phenotypes 26
    • Earliest
      J:29552 Gearing DP, et al., Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 1991 Oct;10(10):2839-48
    • Latest
      J:245455 Cheng J, et al., Tissue-Specific Ablation of the LIF Receptor in the Murine Uterine Epithelium Results in Implantation Failure. Endocrinology. 2017 Jun 01;158(6):1916-1928

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory