About   Help   FAQ
Lifr
Gene Detail
Symbol

Name
ID
Lifr
leukemia inhibitory factor receptor
MGI:96788
Synonyms
A230075M04Rik, soluble differentiation-stimulating factor receptor
Feature Type
protein coding gene
Genetic Map
Chromosome 15
3.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr15:7129559-7197489 bp, + strand
From Ensembl annotation of GRCm38

  67931 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1735  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: LIFR
Gene Tree: Lifr

Human
homologs
LIFR, leukemia inhibitory factor receptor alpha
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3977
neXtProt AC: NX_P42702

Human Synonyms: CD118, LIF-R, SJS2, STWS, SWS

Human Chr (Location): 5p13-p12; chr5:38474963-38595405 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LIFR

Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(31) Targeted(6) Transposon induced(1)
Genomic Mutations involving Lifr (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations die as neonates with reduced numbers of facial and spinal motor neurons, neurons of the nucleus ambiguus, and astrocytes. Mutants also show impaired placentation, severe osteopenia, and low hepatic glycogen stores.
 
Interactions
Lifr interacts with 485 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Expression
Literature Summary: (21 records)
Data Summary: Results (276)    Tissues (53)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 115
Northern blot 98
RT-PCR 14
RNase protection 49
cDNA source data(86)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lifr ; ZFIN lifra, lifrb    NEW 
Molecular
reagents
All nucleic(102) Genomic(12) cDNA(86) Primer pair(3) Other(1)
Microarray probesets(8)
Other database
links
Ensembl Gene Model ENSMUSG00000054263 (Evidence)
Entrez Gene 16880 (Evidence)
UniGene 149720
DFCI TC1584733, TC1595707, TC1628187, TC1631764
DoTS DT.101359067, DT.101359068, DT.101366124, DT.40175389, DT.483877, DT.527655
NIA Mouse Gene Index U016041, U043425
PDB 2Q7N
Consensus CDS Project CCDS27369.1, CCDS49577.1
International Mouse Phenotyping Consortium Status Lifr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054263 Ensembl Gene Model | MGI Sequence Detail 67931 C57BL/6J ±  kb
transcript ENSMUST00000067190 Ensembl | MGI Sequence Detail 4143 Not Applicable 
polypeptide ENSMUSP00000064551 Ensembl | MGI Sequence Detail 1092 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(16) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(540 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved site
Protein Ontology PR:000001876 leukemia inhibitory factor receptor
References
(Earliest) J:29552 Gearing DP, et al., Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 1991 Oct;10(10):2839-48
(Latest) J:219394 Boroviak T, et al., The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
All references(85)
Other
accession IDs
MGD-MRK-11808, MGI:2146188, MGI:2442497

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory