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Lifr Gene Detail
Summary
  • Symbol
    Lifr
  • Name
    leukemia inhibitory factor receptor
  • Synonyms
    A230075M04Rik, soluble differentiation-stimulating factor receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:96788
    NCBI Gene: 16880
Location & Maps
more
  • Sequence Map
    Chr15:7129559-7197489 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      67931 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 3.46 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    LIFR, leukemia inhibitory factor receptor alpha
  • Vertebrate Orthologs
    11
  • Human Ortholog
    LIFR, leukemia inhibitory factor receptor alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD118, LIF-R, SJS2, STWS, SWS
  • Links
    NCBI Gene ID: 3977
    neXtProt AC: NX_P42702

  • Chr Location
    5p13.1; chr5:38474963-38595405 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1735
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LIFR
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human LIFR associations

Human Disease Mouse Models
       Stuve-Wiedemann Syndrome   OMIM: 601559
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    39
  • Gene trapped
    31
  • Targeted
    7
  • Transposon induced
    1
  • Genomic Mutations
    1 involving Lifr
  • Incidental Mutations
Homozygotes for targeted null mutations die as neonates with reduced numbers of facial and spinal motor neurons, neurons of the nucleus ambiguus, and astrocytes. Mutants also show impaired placentation, severe osteopenia, and low hepatic glycogen stores.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054263 Ensembl Gene Model | MGI Sequence Detail 67931 C57BL/6J ±  kb
transcript ENSMUST00000171588 Ensembl | MGI Sequence Detail 9655 Not Applicable  
polypeptide ENSMUSP00000126137 Ensembl | MGI Sequence Detail 1092 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    761 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 105
    Genomic 12
    cDNA 86
    Primer pair 4
    Other 3

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-11808, MGI:2146188, MGI:2442497
References
more
  • Summaries
    All 84
    Developmental Gene Expression 22
    Gene Ontology 7
    Phenotypes 24
  • Earliest
    J:29552 Gearing DP, et al., Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 1991 Oct;10(10):2839-48
  • Latest
    J:232444 Li S, et al., Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation. Biol Reprod. 2016 Feb;94(2):41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory