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Lifr Gene Detail
Summary
  • Symbol
    Lifr
  • Name
    LIF receptor alpha
  • Synonyms
    A230075M04Rik, soluble differentiation-stimulating factor receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:96788
    NCBI Gene: 16880
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:7090615-7197489 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 3.46 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    761 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96788
protein coding gene Chr15:7090614-7197489 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021700
protein coding gene Chr15:4139991-4211455 (+)
A/J MGP_AJ_G0021661
protein coding gene Chr15:4049495-4117650 (+)
AKR/J MGP_AKRJ_G0021639
protein coding gene Chr15:4065109-4140819 (+)
BALB/cJ MGP_BALBcJ_G0021668
protein coding gene Chr15:3958212-4027252 (+)
C3H/HeJ MGP_C3HHeJ_G0021444
protein coding gene Chr15:4102334-4172213 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022107
protein coding gene Chr15:4301837-4373395 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019644
protein coding gene Chr15:3669219-3738707 (+)
CAST/EiJ MGP_CASTEiJ_G0020960
protein coding gene Chr15:4081618-4151564 (+)
CBA/J MGP_CBAJ_G0021413
protein coding gene Chr15:4376534-4449887 (+)
DBA/2J MGP_DBA2J_G0021537
protein coding gene Chr15:3969739-4037810 (+)
FVB/NJ MGP_FVBNJ_G0021515
protein coding gene Chr15:3898417-3966912 (+)
LP/J MGP_LPJ_G0021605
protein coding gene Chr15:4066727-4134486 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021540
protein coding gene Chr15:4569977-4639132 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022130
protein coding gene Chr15:4100560-4171987 (+)
PWK/PhJ MGP_PWKPhJ_G0020703
protein coding gene Chr15:3986835-4057816 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020541
protein coding gene Chr15:3998691-4069154 (+)
WSB/EiJ MGP_WSBEiJ_G0021016
protein coding gene Chr15:4039477-4108293 (+)



Homology
more
  • Human Ortholog
    LIFR, LIF receptor subunit alpha
  • Vertebrate Orthologs
    11
  • Human Ortholog
    LIFR, LIF receptor subunit alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD118, LIF-R, SJS2, STWS, SWS
  • Links
    NCBI Gene ID: 3977
    neXtProt AC: NX_P42702
    UniProt: P42702

  • Chr Location
    5p13.1; chr5:38474963-38606290 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1735
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LIFR
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Lifr mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 3 alleles in 4 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations die as neonates with reduced numbers of facial and spinal motor neurons, neurons of the nucleus ambiguus, and astrocytes. Mutants also show impaired placentation, severe osteopenia, and low hepatic glycogen stores.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16880 NCBI Gene Model | MGI Sequence Detail 106875 C57BL/6J ±  kb
    transcript NM_001358593 RefSeq | MGI Sequence Detail 9876 C57BL/6  
    polypeptide P42703 UniProt | EBI | MGI Sequence Detail 1092 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 107
      Genomic 12
      cDNA 88
      Primer pair 4
      Other 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-11808, MGI:2146188, MGI:2442497
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 28
      Diseases 1
      Gene Ontology 9
      Phenotypes 27
    • Earliest
      J:29552 Gearing DP, et al., Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 1991 Oct;10(10):2839-48
    • Latest
      J:272505 Catela C, et al., An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development. Neural Dev. 2019 Jan 18;14(1):2

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    06/04/2019
    MGI 6.14
    The Jackson Laboratory