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Lifr
Gene Detail
 Symbol
Name
ID
Lifr
leukemia inhibitory factor receptor
MGI:96788
Synonyms A230075M04Rik, soluble differentiation-stimulating factor receptor
Feature Type protein coding gene
Genetic Map
Chromosome 15
3.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr15:7129572-7197489 bp, + strand
From NCBI annotation of GRCm38

  67918 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1735  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Lifr

Human
homologs
Human Homolog LIFR, leukemia inhibitory factor receptor alpha
NCBI Gene ID 3977
neXtProt AC  NX_P42702
Human Synonyms  CD118, LIF-R, SJS2, STWS, SWS
Human Chr (Location)  5p13-p12; chr5:38474963-38595405 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human LIFR
Alleles
and
phenotypes
All alleles(37) : Gene trapped(31) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations die as neonates with reduced numbers of facial and spinal motor neurons, neurons of the nucleus ambiguus, and astrocytes. Mutants also show impaired placentation, severe osteopenia, and low hepatic glycogen stores.
 
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process ciliary neurotrophic factor-mediated signaling pathway, cytokine-mediated signaling pathway, ...
Component extracellular region, integral component of membrane, ...
Function ciliary neurotrophic factor receptor activity, ciliary neurotrophic factor receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (279)    Tissues (55)    Images (34)
Theiler Stages: 1, 2, 3, 4, 13, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 115
Northern blot 98
RT-PCR 17
RNase protection 49
cDNA source data(86)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(102) Genomic(12) cDNA(86) Primer pair(3) Other(1)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000054263 (Evidence)
Entrez Gene16880 (Evidence)
UniGene149720
DFCITC1584733, TC1595707, TC1628187, TC1631764
DoTSDT.101359067, DT.101359068, DT.101366124, DT.40175389, DT.483877, DT.527655
NIA Mouse Gene IndexU016041, U043425
PDB2Q7N
Consensus CDS ProjectCCDS27369.1, CCDS49577.1
International Mouse Knockout Project StatusLifr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16880 NCBI Gene Model | MGI Sequence Detail 67918 C57BL/6J ±  kb
transcript NM_013584 RefSeq | MGI Sequence Detail 9663 C57BL/6 
polypeptide P42703 UniProt | EBI | MGI Sequence Detail 1092 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(15) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(540 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved site
Protein Ontology PR:000001876 leukemia inhibitory factor receptor
Graphical View of Protein Domain Structure
References (Earliest) J:29552 Gearing DP, et al., Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 1991 Oct;10(10):2839-48
(Latest) J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
All references(85)
Other
accession IDs
MGD-MRK-11808, MGI:2146188, MGI:2442497

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory