Lifr
Gene Detail

Symbol Name ID

Lifr leukemia inhibitory factor receptor MGI:96788

Synonyms

A230075M04Rik, soluble differentiation-stimulating factor receptor

Feature Type

protein coding gene

Genetic Map

Chromosome 15

3.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr15:7129572-7197489 bp, + strand From NCBI annotation of GRCm38   67918 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1735  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Lifr

Human homologs

Human Homolog		LIFR, leukemia inhibitory factor receptor alpha
NCBI Gene ID		3977
neXtProt AC		NX_P42702
Human Synonyms		CD118, LIF-R, SJS2, STWS, SWS
Human Chr (Location)		5p13-p12; chr5:38475065-38595507 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LIFR

Alleles and phenotypes

All alleles(36) : Targeted(5) Gene trapped(31)
 

Homozygotes for targeted null mutations die as neonates with reduced numbers of facial and spinal motor neurons, neurons of the nucleus ambiguus, and astrocytes. Mutants also show impaired placentation, severe osteopenia, and low hepatic glycogen stores.

 

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	ciliary neurotrophic factor-mediated signaling pathway, cytokine-mediated signaling pathway, ...
Component	extracellular region, integral to membrane, ...
Function	ciliary neurotrophic factor receptor activity, ciliary neurotrophic factor receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (20 records)
Data Summary: Results (279)    Tissues (55)    Images (34)
Theiler Stages: 1, 2, 3, 4, 13, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	115
Northern blot	98
RT-PCR	17
RNase protection	49

cDNA source data(86)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(102) Genomic(12) cDNA(86) Primer pair(3) Other(1)
Microarray probesets(8)

Other database links

Ensembl Gene Model	ENSMUSG00000054263 (Evidence)
Entrez Gene	16880 (Evidence)
UniGene	149720
DFCI	TC1584733, TC1595707, TC1628187, TC1631764
DoTS	DT.101359067, DT.101359068, DT.101366124, DT.40175389, DT.483877, DT.527655
NIA Mouse Gene Index	U016041, U043425
PDB	2Q7N
Consensus CDS Project	CCDS27369.1, CCDS49577.1
International Mouse Knockout Project Status	Lifr

Sequences

Length	Strain/Species
genomic	16880	NCBI Gene Model | MGI Sequence Detail	67918	C57BL/6J
transcript	NM_013584	RefSeq | MGI Sequence Detail	9663	C57BL/6
polypeptide	P42703	UniProt | EBI | MGI Sequence Detail	1092	Not Applicable

All sequences(44) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(441 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003529	Long hematopoietin receptor, Gp130 family 2, conserved site
Protein Ontology	PR:000001876	leukemia inhibitory factor receptor

Graphical View of Protein Domain Structure

References

(Earliest) J:29552 Gearing DP, et al., Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 1991 Oct;10(10):2839-48
(Latest) J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
All references(83)

Other accession IDs

MGD-MRK-11808, MGI:2146188, MGI:2442497