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Lhcgr Gene Detail
Summary
  • Symbol
    Lhcgr
  • Name
    luteinizing hormone/choriogonadotropin receptor
  • Synonyms
    Gpcr19-rs1, Lhr, LH-R
  • Feature Type
    protein coding gene
  • IDs
    MGI:96783
    NCBI Gene: 16867
Location & Maps
more
  • Sequence Map
    Chr17:88741549-88791976 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      50428 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 58.35 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    LHCGR, luteinizing hormone/choriogonadotropin receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LHCGR, luteinizing hormone/choriogonadotropin receptor
    Orthology source: HomoloGene
  • Synonyms
    HHG, LCGR, LGR2, LH/CGR, LH/CG-R, LHR, LHRHR, LSH-R, ULG5
  • Links
    NCBI Gene ID: 3973
    neXtProt AC: NX_P22888

  • Chr Location
    2p21; chr2:48686774-48755741 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human LHCGR associations

Human Disease Mouse Models
       Leydig Cell Hypoplasia, Type I   OMIM: 238320
Precocious Puberty, Male-Limited   OMIM: 176410
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    103 phenotypes from 4 alleles in 4 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants are infertile and have abnormal hormone levels. Males have undescended testes, immature external and accessory sex organs and blocked spermatogenesis. Females have small ovaries and uteri, immature follicles and do not cycle.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024107 Ensembl Gene Model | MGI Sequence Detail 50428 C57BL/6J ±  kb
transcript ENSMUST00000024916 Ensembl | MGI Sequence Detail 2553 Not Applicable  
polypeptide ENSMUSP00000024916 Ensembl | MGI Sequence Detail 700 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    300 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001596 lutropin-choriogonadotropic hormone receptor
  • InterPro Domains
    IPR002131 Glycoprotein hormone receptor family
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR026906 Leucine rich repeat 5
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR002273 Lutropin-choriogonadotropic hormone receptor
Molecular
Reagents
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  • All nucleic 22
    Genomic 4
    cDNA 11
    Primer pair 6
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11803, MGD-MRK-11804, MGD-MRK-16386, MGI:96784
References
more
  • Summaries
    All 85
    Developmental Gene Expression 14
    Gene Ontology 9
    Phenotypes 29
  • Earliest
    J:32180 McFarland KC, et al., Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family. Science. 1989 Aug 4;245(4917):494-9
  • Latest
    J:226139 Laissue P, Aetiological coding sequence variants in non-syndromic premature ovarian failure: From genetic linkage analysis to next generation sequencing. Mol Cell Endocrinol. 2015 Aug 15;411:243-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory