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Lhcgr
Gene Detail
Symbol

Name
ID
Lhcgr
luteinizing hormone/choriogonadotropin receptor
MGI:96783
Synonyms
Gpcr19-rs1, Lhr, LH-R
Feature Type
protein coding gene
Genetic Map
Chromosome 17
58.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr17:88741549-88791976 bp, - strand
From NCBI annotation of GRCm38

  50428 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: glycoprotein hormone receptor
Gene Tree: Lhcgr

Human
homologs
Human Homolog LHCGR, luteinizing hormone/choriogonadotropin receptor
NCBI Gene ID 3973
neXtProt AC  NX_P22888
Human Synonyms  HHG, LCGR, LGR2, LH/CGR, LH/CG-R, LHR, LHRHR, LSH-R, ULG5
Human Chr (Location)  2p21; chr2:48686774-48755741 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human LHCGR
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants are infertile and have abnormal hormone levels. Males have undescended testes, immature external and accessory sex organs and blocked spermatogenesis. Females have small ovaries and uteri, immature follicles and do not cycle.
 
Interactions
Lhcgr interacts with 101 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (27)    Tissues (11)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 6
RT-PCR 21
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(4) cDNA(11) Primer pair(6) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000024107 (Evidence)
Entrez Gene16867 (Evidence)
UniGene1644
DFCITC1588814, TC1611247
DoTSDT.55276751, DT.91299338, DT.91335273, DT.91361712
NIA Mouse Gene IndexU038151
Consensus CDS ProjectCCDS29025.1
International Mouse Knockout Project StatusLhcgr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16867 NCBI Gene Model | MGI Sequence Detail 50428 C57BL/6J ±  kb
transcript NM_013582 RefSeq | MGI Sequence Detail 2553 C57BL/6 
polypeptide P30730 UniProt | EBI | MGI Sequence Detail 700 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(20) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(301 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002131 Glycoprotein hormone receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR026906 Leucine rich repeat 5
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR002273 Lutropin-choriogonadotropic hormone receptor
Protein Ontology PR:000001596 lutropin-choriogonadotropic hormone receptor
Graphical View of Protein Domain Structure
References
(Earliest) J:32180 McFarland KC, et al., Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family. Science. 1989 Aug 4;245(4917):494-9
(Latest) J:203295 McGee SR, et al., Precocious puberty and Leydig cell hyperplasia in male mice with a gain of function mutation in the LH receptor gene. Endocrinology. 2013 Oct;154(10):3900-13
All references(85)
Other
accession IDs
MGD-MRK-11803, MGD-MRK-11804, MGD-MRK-16386, MGI:96784

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory