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Lhcgr
Gene Detail
Symbol

Name
ID
Lhcgr
luteinizing hormone/choriogonadotropin receptor
MGI:96783
Synonyms
Gpcr19-rs1, Lhr, LH-R
Feature Type
protein coding gene
Genetic Map
Chromosome 17
58.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr17:88741549-88791976 bp, - strand
From Ensembl annotation of GRCm38

  50428 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LHCGR
Protein SuperFamily: glycoprotein hormone receptor
Gene Tree: Lhcgr

Human
homologs
LHCGR, luteinizing hormone/choriogonadotropin receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3973
neXtProt AC: NX_P22888

Human Synonyms: HHG, LCGR, LGR2, LH/CGR, LH/CG-R, LHR, LHRHR, LSH-R, ULG5

Human Chr (Location): 2p21; chr2:48686774-48755741 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human LHCGR

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants are infertile and have abnormal hormone levels. Males have undescended testes, immature external and accessory sex organs and blocked spermatogenesis. Females have small ovaries and uteri, immature follicles and do not cycle.
 
Interactions
Lhcgr interacts with 100 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (14 records)
Data Summary: Results (27)    Tissues (11)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 6
RT-PCR 21
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lhcgr ; ZFIN lhcgr    NEW 
Molecular
reagents
All nucleic(22) Genomic(4) cDNA(11) Primer pair(6) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000024107 (Evidence)
Entrez Gene 16867 (Evidence)
UniGene 1644
DFCI TC1588814, TC1611247
DoTS DT.55276751, DT.91299338, DT.91335273, DT.91361712
NIA Mouse Gene Index U038151
Consensus CDS Project CCDS29025.1
International Mouse Phenotyping Consortium Status Lhcgr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024107 Ensembl Gene Model | MGI Sequence Detail 50428 C57BL/6J ±  kb
transcript ENSMUST00000024916 Ensembl | MGI Sequence Detail 2553 Not Applicable 
polypeptide ENSMUSP00000024916 Ensembl | MGI Sequence Detail 700 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(26) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(301 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002131 Glycoprotein hormone receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR026906 Leucine rich repeat 5
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR002273 Lutropin-choriogonadotropic hormone receptor
Protein Ontology PR:000001596 lutropin-choriogonadotropic hormone receptor
References
(Earliest) J:32180 McFarland KC, et al., Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family. Science. 1989 Aug 4;245(4917):494-9
(Latest) J:222045 Padua MB, et al., Combined loss of the GATA4 and GATA6 transcription factors in male mice disrupts testicular development and confers adrenal-like function in the testes. Endocrinology. 2015 May;156(5):1873-86
All references(86)
Other
accession IDs
MGD-MRK-11803, MGD-MRK-11804, MGD-MRK-16386, MGI:96784

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory