Lhcgr
Gene Detail

Symbol Name ID

Lhcgr luteinizing hormone/choriogonadotropin receptor MGI:96783

Synonyms

Gpcr19-rs1, Lhr, LH-R

Feature Type

protein coding gene

Genetic Map

Chromosome 17

58.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr17:88741549-88791976 bp, - strand From NCBI annotation of GRCm38   50428 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glycoprotein hormone receptor
Gene Tree: Lhcgr

Human homologs

Human Homolog		LHCGR, luteinizing hormone/choriogonadotropin receptor
NCBI Gene ID		3973
neXtProt AC		NX_P22888
Human Synonyms		HHG, LCGR, LGR2, LH/CGR, LH/CG-R, LHR, LHRHR, LSH-R, ULG5
Human Chr (Location)		2p21; chr2:48913913-48982880 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human LHCGR

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous null mutants are infertile and have abnormal hormone levels. Males have undescended testes, immature external and accessory sex organs and blocked spermatogenesis. Females have small ovaries and uteri, immature follicles and do not cycle.

 

Gene Ontology (GO) classifications

All GO classifications: (56 annotations)

Process	activation of adenylate cyclase activity, adenylate cyclase-modulating G-protein coupled receptor signaling pathway, ...
Component	cytoplasm, endoplasmic reticulum, ...
Function	ATPase binding, choriogonadotropin hormone binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (27)    Tissues (10)    Images (5)
Theiler Stages: 1, 2, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	6
RT-PCR	21

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(4) cDNA(10) Primer pair(6) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000024107 (Evidence)
Entrez Gene	16867 (Evidence)
UniGene	1644
DFCI	TC1588814, TC1611247
DoTS	DT.55276751, DT.91299338, DT.91335273, DT.91361712
NIA Mouse Gene Index	U038151
Consensus CDS Project	CCDS29025.1
International Mouse Knockout Project Status	Lhcgr

Sequences

Length	Strain/Species
genomic	16867	NCBI Gene Model | MGI Sequence Detail	50428	C57BL/6J
transcript	NM_013582	RefSeq | MGI Sequence Detail	2553	C57BL/6
polypeptide	P30730	UniProt | EBI | MGI Sequence Detail	700	Not Applicable

All sequences(21) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(2) : SNPs(195 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002131	Glycoprotein hormone receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR026906	Leucine rich repeat 5
InterPro	IPR000372	Leucine-rich repeat-containing N-terminal
InterPro	IPR002273	Lutropin-choriogonadotropic hormone receptor
Protein Ontology	PR:000001596	lutropin-choriogonadotropic hormone receptor

Graphical View of Protein Domain Structure

References

(Earliest) J:32180 McFarland KC, et al., Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family. Science. 1989 Aug 4;245(4917):494-9
(Latest) J:189958 Buaas FW, et al., In vivo evidence for the crucial role of SF1 in steroid-producing cells of the testis, ovary and adrenal gland. Development. 2012 Dec;139(24):4561-70
All references(83)

Other accession IDs

MGD-MRK-11803, MGD-MRK-11804, MGD-MRK-16386, MGI:96784